AUTHOR=Duan Ranran , Wang Na , Shang Yanan , Li Hengfen , Liu Qian , Li Li , Zhao Xiaofeng 

TITLE=TNF-α (G-308A) Polymorphism, Circulating Levels of TNF-α and IGF-1: Risk Factors for Ischemic Stroke—An Updated Meta-Analysis

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 14 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.831910

DOI=10.3389/fnagi.2022.831910

ISSN=1663-4365

ABSTRACT=Objective:Accumulated studies have explored gene polymorphisms，circulating levels of TNF-α and IGF-1 in the etiology of Ischemic stroke (IS). Of the numerous etiopathological factors for IS, a single-nucleotide polymorphisms (SNPs) rs1800629 located in the TNF-α gene promoter region and increased levels of TNF-α were found to be associated with IS in different ethnic backgrounds. However, the published results are inconsistent and inconclusive. The primary objective of this meta-analysis was to investigate the concordance between rs1800629 polymorphism and IS. As secondary aims we explore circulating levels of TNF-α and IGF-1 with IS in different ethnic background，differentially sourced specimens. 
Methods:In this study, we examined whether rs1800629 genetic variants, levels of TNF-α and IGF-1 were related to the etiology of IS by performing a meta-analysis. Relevant case-control studies were retrieved by database searching and systematically selected according to established inclusion criteria. 
Results:47 articles were identified that explored the relationship between the rs1800629 polymorphism, levels of the TNF-α and IGF-1 with IS risk susceptibility. Statistical analyses revealed a significant association between the rs1800629 polymorphism, levels of TNF-α and IGF-1 with IS pathogenesis. 
Conclusion:Our findings demonstrated that the TNF-α rs1800629 polymorphisms, the increased levels of TNF-α and decreased IGF-1 were involved in the etiology of IS.