AUTHOR=Zhao Xuemiao , He Haijun , Xiong Xi , Ye Qianqian , Feng Feifei , Zhou Shuoting , Chen Weian , Xia Kai , Qian Shuangjie , Yang Yunjun , Xie Chenglong 

TITLE=Lewy Body-Associated Proteins A-Synuclein (a-syn) as a Plasma-Based Biomarker for Parkinson’s Disease

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 14 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.869797

DOI=10.3389/fnagi.2022.869797

ISSN=1663-4365

ABSTRACT=Introduction: To explore the combined diagnostic value of plasma Lewy body-associated proteins (p-Asyn at ser129, total α-syn and oligomeric α-syn) for the diagnosis of PD versus healthy controls (HCs) and another PDs and clinical characteristics prediction.
Methods: This study included 146 participants: 77 patients with PD, 27 patients with PDs, and 42 healthy controls. A panel of plasma levels of p-Asyn, total α-syn and oligomeric α-syn were measured by enzyme-linked immunosorbent assay (ELISA). Primary outcome was the discriminative accuracy of combined three plasma biomarkers for PD.
Results: The mean age was 65.43 (SD, 7.467) in control group, 64.33 (SD, 8.19) in PD participants, 69.42 (SD, 7.685) in PDs. The plasma Lewy body-associated proteins levels were significantly higher in patients with PD than age-matched healthy controls, However, there was no difference in patients with PD and PDs. Of note, combination of plasma p-Asyn, total α-syn and oligomeric α-syn is a better biomarker for discriminating PD from healthy controls, with an AUC of 0.8552 (p < 0.0001, 95%CI, 0.7635 to 0.9409), which was significantly higher than for plasma p-Asyn (ΔAUC, 0.1797), total α-syn (ΔAUC, 0.0891) and oligomeric α-syn (ΔAUC, 0.1592) alone. Meanwhile, Lewy body-associated proteins were no relationship between different motor stages and dementia performances et al.
Conclusion: Our results suggested that plasma Lewy body-associated proteins, may serve as a non-invasive biomarker to aid diagnosis of PD from Healthy controls. In addition, increased plasma Lewy body-associated proteins were not associated with progression of motor and non-motor symptoms.