AUTHOR=Wu Zhuang , Hong Ronghua , Li Shuangfang , Peng Kangwen , Lin Ao , Gao Yichen , Jin Yue , Su Xiaoyun , Zhi Hongping , Guan Qiang , Pan Lizhen , Jin Lingjing 

TITLE=Technology-based therapy-response evaluation of axial motor symptoms under daily drug regimen of patients with Parkinson’s disease

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 14 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.901090

DOI=10.3389/fnagi.2022.901090

ISSN=1663-4365

ABSTRACT=Background: Axial disturbances are the most disabling symptoms in Parkinson’s Disease (PD). Kinect-based objective measures could extract motion characteristics with high reliability and validity. 
Purpose: The present research aimed to quantify the therapy-response of axial motor symptoms to daily medication regimen and to explore the correlates of the improvement rate (IR) of axial motor symptoms based on Kinect camera.
Methods: We enrolled 44 PD patients and 21 healthy controls. All 65 participants performed Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale part Ⅲ and Kinect-based kinematic evaluation to assess arising from a chair, gait, posture and postural stability before and after medication. Spearman correlation analysis and multiple linear regression model were performed to explore the relationships between motor feature IR and clinical data.
Results: All the features of arising from a chair (P=0.001), stride length (P=0.001), velocity (P<0.001), the height of foot lift (P<0.001) and turning time (P=0.001) improved significantly after daily drug regimen in PD patients. In addition, anterior trunk flexion (lumbar level) exhibited significant improvement (P=0.004). The IR of axial motor symptom score was significantly correlated with the IRs of kinematic features for gait velocity, stride length, foot lift height and sitting speed (rs=0.345, P=0.022; rs=0.382, P=0.010; rs=0.314, P=0.038; rs=0.518, P<0.001, respectively). Multivariable regression analysis showed that the improvement in axial motor symptom was associated with the IR of gait velocity only (β=0.593, 95% confidence interval=0.023-1.164, P=0.042).
Conclusion: Axial symptom was not complete drug-resistant and some kinematic features can be improved after daily medication regimen of PD patients.