AUTHOR=Cheng Yanyong , Shi Lingling , Mao Haoli , Xue Zhenyu , Liu Siyu , Qiu Zilong , Zhang Lei , Jiang Hong 

TITLE=The Effect of Sevoflurane Anesthesia on the Biomarkers of Neural Injury in the Prefrontal Cortex of Aged Marmosets

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 14 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.918640

DOI=10.3389/fnagi.2022.918640

ISSN=1663-4365

ABSTRACT=Background: Previous studies have suggested that older patients undergoing surgery under anesthesia could be at an increased risk for the neural injury. Sevoflurane anesthesia without surgery for 2 h does not induce neural injury, however, whether prolonger sevoflurane anesthesia without surgery induces it is still unknown. 
Methods: In present study, marmosets were exposed at clinical concentration of sevoflurane (1.5% to 2%) for 6 h to access the effects of sevoflurane anesthesia on the levels of IL-6 and TNF-α, Caspase3 activity and myelin formation in brain tissues.
Results: Sevoflurane anesthesia did not alter the expression of IL-6 (120.1±2.21 vs. 120.8±2.25, p = 0.74), TNF-α (189.3±31.35 vs. 218.7±21.47, p = 0.25) and Caspase3 (57.35±1.54 vs. 58.67±1.19, p = 0.53) in the prefrontal cortex of aged marmosets. The amount of MBP expression (60.99±6.21 vs. 58.91±2.71, p = 0.77) did not change upon sevoflurane exposure.
Conclusion: Sevoflurane anesthesia did not increase the levels of IL-6 and TNF-α, activated the expression of Caspase3 and induced myelination deficits in the prefrontal cortex of aged marmosets.