AUTHOR=Wang Ming-Liang , Sun Zheng , Li Wen-Bin , Zou Qiao-Qiao , Li Peng-Yang , Wu Xue , Li Yue-Hua , the 4-Repeat Tau Neuroimaging Initiative and the Frontotemporal Lobar Degeneration Neuroimaging Initiative TITLE=Enlarged perivascular spaces and white matter hyperintensities in patients with frontotemporal lobar degeneration syndromes JOURNAL=Frontiers in Aging Neuroscience VOLUME=Volume 14 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.923193 DOI=10.3389/fnagi.2022.923193 ISSN=1663-4365 ABSTRACT=Objective: To investigate the distribution characteristics of enlarged perivascular spaces (EPVS) and white matter hyperintensities (WMH) and their associations with disease severity across the frontotemporal lobar degeneration (FTLD) syndromes spectrum. Methods: This study included 73 controls, 39 progressive supranuclear palsy Richardson’s syndrome (PSP-RS), 31 corticobasal syndrome (CBS), 47 behavioral variant frontotemporal dementia (bvFTD), 36 nonfluent variant primary progressive aphasia (nfvPPA) and 50 semantic variant primary progressive aphasia (svPPA). All subjects had brain MRI and neuropsychological tests including progressive supranuclear palsy rating scale (PSPRS) and FTLD modified clinical dementia rating sum of boxes (FTLD-CDR). EPVS number and grade were rated on MRI in the centrum semiovale (CSO-EPVS), basal ganglia (BG-EPVS) and brain stem (BS-EPVS). Periventricular (PWMH) and deep (DWMH) were also graded on MRI. The distribution characteristics of EPVS, WMH were compared between control and disease groups. Multivariable linear regression analysis was performed to evaluate the association of EPVS and WMH with disease severity. Results: Compared with control subjects, PSP-RS and CBS had more BS-EPVS; CBS, bvFTD, and nfvPPA had less CSO-EPVS; all disease group except CBS had higher PWMH (p<0.05). BS-EPVS was associated with PSPRS in PSP-RS (β= 2.395, 95% confidence interval [CI] 0.888 – 3.901) and CBS (β= 3.115, 95% CI 1.584 – 4.647). PWMH was associated with FTLD-CDR in bvFTD (β= 1.823, 95% CI 0.752 – 2.895), nfvPPA (β= 0.971, 95% CI 0.030 – 1.912) and svPPA (OR: 1.330, 95% CI 0.457 – 2.204). Conclusions: BS-EPVS could be a promising indicator of disease severity in PSP-RS and CBS, while PWMH could reflect the severity of bvFTD, nfvPPA and svPPA.