AUTHOR=Wang Cheng-Cheng , Kong Jing-Ya , Li Xiao-Yue , Yang Jin-Yue , Xue Chang-Hu , Yanagita Teruyoshi , Wang Yu-Ming 

TITLE=Antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency in SAMP8 mice: Applying the perspective of the sea–land combination to retard brain aging

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 14 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.964077

DOI=10.3389/fnagi.2022.964077

ISSN=1663-4365

ABSTRACT=The complex pathogenesis of AD leads to the limited therapeutic effect; therefore, the combination of multiple bioactive ingredients may be more effective in improving AD due to synergistic effects. Based on sea-land combination perspective, the effects of sea-derived Antarctic krill oil (AKO) combined with land-derived nobiletin (Nob) and L-theanine (The) on memory decline and cognitive deficiency were studied in the senescence-accelerated prone 8 mice (SAMP8). Results demonstrated that AKO combined with The significantly increased the number of crossing the platform in Morris Water Maze test, increased by 1.6 folds, and AKO combined with Nob significantly increased the preference index in novel object recognition test. AKO exhibited synergistic effects with Nob and The on ameliorating recognition memory and spatial memory deficiency in SAMP8 mice, respectively. Further mechanism research indicated that AKO exhibited synergistic effects with Nob on suppressing Aβ aggregation, neurofibrillary tangles and apoptosis and neuroinflammation, while the synergistic effects of AKO and The involved in synaptic plasticity and anti-neuroinflammation, which revealed that the combination was complex, not a mechanical addition. These findings revealed that sea-land combination may be an effective strategy to treat and alleviate AD.