AUTHOR=Luo Jing , Zhu Hui-Qi , Gou Bo , Zheng Yi-Li TITLE=Mechanisms of exercise for diabetic neuropathic pain JOURNAL=Frontiers in Aging Neuroscience VOLUME=Volume 14 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.975453 DOI=10.3389/fnagi.2022.975453 ISSN=1663-4365 ABSTRACT=Diabetic neuropathic pain (DNP) is a common disease that affects the daily lives of diabetic patients and its incidence rate worldwide is very high. At present, drug and exercise therapy are common treatments for DNP. Drug therapy has various side effects, and in recent years, exercise therapy has received frequent research and increasing attention. Currently, the treatment of DNP is generally symptomatic. We can better select the appropriate exercise prescription for DNP only by clarifying the exercise mechanism for its therapy. The unique pathological mechanism of DNP is still unclear and may be related to the pathological mechanism of diabetic neuropathy. In this paper, the mechanisms of exercise therapy for DNP from the pathological mechanism of DNP were reviewed to better understand the role of exercise therapy in treating DNP.