AUTHOR=Zhou Bojun , Wang Zhisheng , Zhu Lianghao , Huang Gang , Li Bing , Chen Chaofan , Huang Junda , Ma Fuhai , Liu Timon Chengyi TITLE=Effects of different physical activities on brain-derived neurotrophic factor: A systematic review and bayesian network meta-analysis JOURNAL=Frontiers in Aging Neuroscience VOLUME=Volume 14 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.981002 DOI=10.3389/fnagi.2022.981002 ISSN=1663-4365 ABSTRACT=Background: Emerging evidence suggests that exercise is a simple and effective method for maintaining brain function. Aims: This review evaluates the effects of five physical exercises, including aerobic training (AT), high-intensity interval training (HIIT), combined training (CT), resistance training (RT), and AT+RT, on the serum level of brain-derived neurotrophic factor (BDNF) in healthy and non-healthy populations. Methods:We searched CNKI, PubMed, Embase, Scopus, Medline, Web of Science, and Cochrane Library databases to review randomized controlled studies on exercise interventions for BDNF. Quantitative merging analysis of the resulting data using Bayesian network meta-analysis. Results: A total of 39 randomized controlled trials (RCTs) investigating the effects of exercise treatments on serum BDNF levels in 2031 subjects with ages between 15.60 and 92.3 years and publications between January 1990 and May 2022 were studied. The AT, RT, AT+RT, HIIT, and CT groups (intervention groups) and the CG group (conventional control group) were assigned to 451, 236, 102, 84, 293, and 865 subjects, respectively. The Bayesian network meta-analysis ranked the effect of exercise on BDNF level improvement in healthy and non-healthy subjects as follows: RT > HIIT > CT > AT+RT > AT > CG. Better outcomes were observed in all five intervention groups than in the CG group, with RT having the most significant effect [MD=3.11 (0.33, 5.76), p<0.05]. Conclusions: RT at moderate intensity is recommended for children and older adults in the case of exercise tolerance and is effective in maintaining or modulating BDNF levels for promoting brain health.