AUTHOR=Cao Fang , Yang Mei , Cheng Yuqi , Zhang Xiuyue , Shi Li , Li Na 

TITLE=Correlation analysis of monocyte chemoattractant protein-1 and clinical characteristics and cognitive impairment in type 2 diabetes mellitus comorbid major depressive disorder

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 15 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2023.1081393

DOI=10.3389/fnagi.2023.1081393

ISSN=1663-4365

ABSTRACT=Introduction:Type 2 diabetes mellitus(T2DM) and major depressive disorder(MDD) are both chronic diseases, which are comorbid conditions. Usually,cognitive impairment is the common result of both diseases,but the underlying pathogenesis are not clear. Studies have shown that inflammation, especially monocyte chemotaxis protein-1 (MCP1),could be associated with the pathogenesis of type 2 diabetes mellitus comorbid major depressive disorder.      
Aims: To investigate the correlations of MCP1 with clinical characteristics and cognitive impairment in type 2 diabetes mellitus patients combined with major depressive disorder.
Methods: A total of 84 participants were recruited in this study, including 24 healthy controls (HC) , 21 T2DM patients, 23 MDD patients, and 16 T2DM combined with MDD (TD) patients, to measure the serum MCP1 levels using Enzyme-linked Immunosorbent Assay(ELISA).And the cognitive function, depression, and anxiety degree were assessed using Repeatable Battery for the Assessment of Neuropsychological Status(RBANS),17-item Hamilton Depression Scale (HAMD-17) and Hamilton Anxiety Scale (HAMA) respectively.
Results:(1) Serum MCP1 expression levels in the TD group were higher than HC, T2DM, and MDD groups respectively（p<0.05）. And compared with HC and MDD groups, serum MCP1 levels in the T2DM group were higher (p<0.05) statistically. Receiver Operating Characteristic(ROC) curve showed that MCP1 could diagnose T2DM at cut off values of 503.8pg/ml(sensitivity 80.95%, specificity 79.17%,AUC=0.7956) and of 718.1pg/ml for TD(sensitivity 81.25%, specificity 91.67%,AUC=0.9271) .（2）Group difference about cognitive function were significant. Compared with the HC group, total RBANS scores, attention scores, and language scores in the TD group were lower respectively(p<0.05)，and total RBANS scores, attention scores,and visuospatial/ constructional scores in the MDD group were lower respectively(p<0.05). Compared with the T2DM group, immediate memory scores in HC, MDD, and TD groups were lower respectively, and total RBANS scores in TD were lower (p<0.05). (3)Correlation analysis showed that hip circumference was negatively correlated with MCP1 levels in T2DM group(R=-0.483, p=0.027), but the correlation disappeared after adjusting age and gender(r=−0.372; P=0.117),and there were no significant correlations between MCP1 and other variables.
Conclusion: MCP1 may be involved in the pathophysiology of type 2 diabetes mellitus patients combined with major depressive disorder. And MCP1 may be significant for the early evaluation and diagnosis of TD in the future.