AUTHOR=Song Ruiyao , Guo Yunchu , Fu Yu , Ren Hongling , Wang Hairong , Yan Hongting , Ge Yusong 

TITLE=Trends of mitochondrial changes in AD: a bibliometric study

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 15 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2023.1136400

DOI=10.3389/fnagi.2023.1136400

ISSN=1663-4365

ABSTRACT=Background: Alzheimer’s disease(AD) is a neurodegenerative disease characterized by memory loss. Studies have found mitochondrial dysfunction in AD brain cells which links to other biochemical changes in AD and provide prospect for clinical treatment research. However, few bibliometric analysis have published in this field. We aim to adopt a bibliometric analysis to conduct qualitative and quantitative evaluations of research on mitochondrial dysfunction in Alzheimer’s disease and provide research trends and hotspots in this field.
Methods: We used the Web of Science as a literature retrieval tool to obtain data related to mitochondrial changing of Alzheimer’s disease during the last 20 years. The retrieval type was (TS= (Alzheimer’s disease)) ND (TS=(mitochondrion)) ranged from January 1st 2000 to June 30th 2022. VOSviewer v1.6.18 made relevant network visualization map of the co-authorship, co-occurrence, co-cited in countries/regions, institutions, authors, journals and hotspot keywords. And Journal Citation Reports was used to consult the latest journal import factor and JCI quartile.
Results: As of June 30, 2022, from the web of science core collection, we selected 2474 original articles in English, excluding the document types of news item, meeting abstract and some articles which had little relevance to our theme. The United States acted as the leader and enjoyed a high reputation in this field. The University of California System was the institution made the greatest contribution (3.64% with 90 papers). Most articles were published in Journal of Alzheimer’s Disease (8.21%, with 203 papers). The most frequently co-cited journal in Q1 was Journal of Biological Chemistry (8666 citations, TLS: 1039591). Swerdlow, Russell H. (55 publications) was the most productive author and Reddy, PH was the most co-cited author with 1264 citations (TLS: 62971). The hotpots of mitochondrial dysfunction in AD were as follows: Abnormal mitochondrial dynamics, the direction relationship between abnormal mitochondria and oxidative damage, the cytochrome C oxidase deficiency, modulation of the endoplasmic reticulum-mitochondria interface and high levels of mitochondrial DNA deletions in substantia nigra neurons. 
Conclusions: This bibliometric analysis research devoted to help both researchers and non-researchers to rapidly identify the current hotpots and milestone studies related to their interested fields.