AUTHOR=Yang Huanying , Wang Xiangfu , Wang Xuetao , Yang Jianxia , Zhang Wanqian , Ding Yanfang , Sang Tingrui , Chen Weiguo , Wang Wanhong TITLE=Effect of mindfulness-based mind-body therapies in patients with non-specific low back pain—A network meta-analysis of randomized controlled trials JOURNAL=Frontiers in Aging Neuroscience VOLUME=Volume 15 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2023.1148048 DOI=10.3389/fnagi.2023.1148048 ISSN=1663-4365 ABSTRACT=Background/objectives: Although mindfulness-based mind-body therapy (MBMBT) is an effective nonsurgical treatment for patients with nonspecific low back pain (NLBP), the best MBMBT mode of treatment for NLBP patients has not been identified. Therefore, a network meta-analysis (NMA) was conducted to compare the effects of different MBMBTs in the treatment of NLBP patients. Methods: PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and Web of Science databases were searched for randomized controlled trials (RCTs) applying MBMBT for the treatment of NLBP patients, with all of the searches ranging from the time of database creation to January 2023. After 2 researchers independently screened the literature, extracted information, and evaluated the risks of biases in the included studies, the data were analyzed by using Stata 16.0 software. Results: A total of 46 RCTs were included, including 3,886 NLBP patients and 9 MBMBT patients (Yoga, Ayurvedic Massage, Pilates, Craniosacral Therapy, Meditation, Meditation + Yoga, Qigong, Tai Chi, and Dance). The results of the NMA showed that Craniosacral Therapy (surface under the cumulative ranking [SUCRA]: 99.2% and 99.5%) ranked the highest in terms of improving pain and disability, followed by Other Manipulations (SUCRA: 80.6% and 90.8%) and Pilates (SUCRA: 54.5% and 71.2%). In terms of improving physical health, Craniosacral Therapy (SUCRA: 100%) ranked the highest, followed by Pilates (SUCRA: 72.3%) and Meditation (SUCRA: 55.9%). In terms of improv-ing mental health, Craniosacral Therapy (SUCRA: 100%) ranked the highest, followed by Meditation (SUCRA: 70.7%) and Pilates (SUCRA: 63.2%). However, in terms of improving pain, physical health, and mental health, Usual Care (SUCRA: 7.0%, 14.2% and 11.8%, respectively) ranked lowest. More-over, in terms of improving disability, Dance (SUCRA: 11.3%) ranked lowest. Conclusion: This NMA shows that Craniosacral Therapy may be the most effective MBMBT in treat-ing NLBP patients and deserves to be promoted for clinical use.