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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Aging Neurosci.</journal-id>
<journal-title>Frontiers in Aging Neuroscience</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Aging Neurosci.</abbrev-journal-title>
<issn pub-type="epub">1663-4365</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fnagi.2023.1208392</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Neuroscience</subject>
<subj-group>
<subject>Original Research</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>The effect of accompanying anxiety and depression on patients with different vestibular syndromes</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name><surname>Feng</surname> <given-names>Shuai</given-names></name>
<uri xlink:href="http://loop.frontiersin.org/people/2286662/overview"/>
</contrib>
<contrib contrib-type="author" corresp="yes">
<name><surname>Zang</surname> <given-names>Jian</given-names></name>
<xref ref-type="corresp" rid="c001"><sup>&#x002A;</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/2350011/overview"/>
</contrib>
</contrib-group>
<aff><institution>Department of Otolaryngology, The First Hospital of China Medical University</institution>, <addr-line>Shenyang</addr-line>, <country>China</country></aff>
<author-notes>
<fn fn-type="edited-by"><p>Edited by: Dan Zhang, Tsinghua University, China</p></fn>
<fn fn-type="edited-by"><p>Reviewed by: Florian Sch&#x00F6;berl, LMU Munich University Hospital, Germany; Maurizio Versino, Humanitas Mater Domini, Italy</p></fn>
<corresp id="c001">&#x002A;Correspondence: Jian Zang, <email>jzang@cmu.edu.cn</email></corresp>
</author-notes>
<pub-date pub-type="epub">
<day>01</day>
<month>08</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="collection">
<year>2023</year>
</pub-date>
<volume>15</volume>
<elocation-id>1208392</elocation-id>
<history>
<date date-type="received">
<day>19</day>
<month>04</month>
<year>2023</year>
</date>
<date date-type="accepted">
<day>17</day>
<month>07</month>
<year>2023</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x00A9; 2023 Feng and Zang.</copyright-statement>
<copyright-year>2023</copyright-year>
<copyright-holder>Feng and Zang</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p></license>
</permissions>
<abstract>
<sec>
<title>Objective</title>
<p>This study aims to investigate the situation of vertigo disorder combined with anxiety and depression in patients with different types of vestibular syndrome.</p>
</sec>
<sec>
<title>Methods</title>
<p>A total of 330 patients with vertigo in otolaryngology outpatient department were selected, and clinical information such as age, gender, and scores of Dizziness handicap inventory (DHI), Generalized anxiety disorder-7 (GAD-7), and Patient Health Questionnaire-9 (PHQ-9) were collected. Analyzed the differences among acute vestibular syndrome (AVS), episodic vestibular syndrome (EVS) and chronic vestibular syndrome (CVS) in terms of age, gender, comorbid anxiety and depression, and the multivariate ordered logistic regression analysis was used to evaluate the relationship between the above factors and the degree of vertigo disorder.</p>
</sec>
<sec>
<title>Results</title>
<p>The three types of vestibular syndrome had no significant difference in age composition, sex composition, anxiety and depression. There was no significant difference in the probability of anxiety and depression among vertigo patients of different ages and genders. The total score of vertigo disorder and each sub-item score were higher in patients with anxiety and depression. Patients with anxiety mainly manifested in EVS and CVS, while patients with depression mainly manifested in EVS and AVS. The probability of increased vertigo in anxious patients was 4.65 times that of non-anxious patients, and the probability of increased vertigo in depressed patients was 3.49 times that of non-depressed patients. Age and gender had no statistically significant effect on the degree of vertigo. In patients with EVS, anxiety and depression had a significant effect on the degree of vertigo; in patients with CVS, anxiety had a significant effect on the degree of vertigo, but depression had no significant effect.</p>
</sec>
<sec>
<title>Conclusion</title>
<p>Age and gender do not significantly affect the degree of vertigo disorder and mental state in various vestibular syndromes. Instead, anxiety and depression are the risk factors for aggravating the degree of vertigo disorder, and manifest differently in each type of vestibular syndrome. Therefore, it is necessary to use a quick scale tool to conduct a standardized screening of the psychological status of patients with vertigo.</p>
</sec>
</abstract>
<kwd-group>
<kwd>vertigo</kwd>
<kwd>vestibular syndrome</kwd>
<kwd>anxiety</kwd>
<kwd>depression</kwd>
<kwd>dizziness handicap inventory</kwd>
</kwd-group>
<contract-sponsor id="cn001">Natural Science Foundation of Liaoning Province<named-content content-type="fundref-id">10.13039/501100005047</named-content></contract-sponsor>
<counts>
<fig-count count="1"/>
<table-count count="7"/>
<equation-count count="0"/>
<ref-count count="54"/>
<page-count count="11"/>
<word-count count="7257"/>
</counts>
<custom-meta-wrap>
<custom-meta>
<meta-name>section-at-acceptance</meta-name>
<meta-value>Neurocognitive Aging and Behavior</meta-value>
</custom-meta>
</custom-meta-wrap>
</article-meta>
</front>
<body>
<sec id="S1" sec-type="intro">
<title>1. Introduction</title>
<p>Vertigo, a common clinical symptom, is the most prominent manifestation of vestibular disorders. Dysfunction of the vestibular system can lead to a variety of symptoms, from vertigo, vision and balance problems, to mood, memory, and self-perception problems. Large population-based studies have shown that dizziness and vertigo affect approximately 15% to over 20% of adults annually. Vestibular vertigo accounts for approximately 1/4 of dizziness complaints and can cause unilateral or bilateral deterioration and loss of vestibular function, which can significantly impact work and living activities (<xref ref-type="bibr" rid="B42">Quimby et al., 2018</xref>). The prevalence of vertigo increases with age and is approximately 2&#x2013;3 times higher in women than in men. An epidemiological study in the United States showed that the number of patients with dizziness and balance disorders as the chief complaint was about 33 million, for an annual prevalence of 14.8% (<xref ref-type="bibr" rid="B22">Kerber et al., 2017</xref>).</p>
<p>The 2015 International Classification of Vestibular Disorders (ICVD) divides vestibular disorders into acute vestibular syndrome (AVS), episodic vestibular syndrome (EVS), and chronic vestibular syndrome (CVS) (<xref ref-type="bibr" rid="B7">Bisdorff et al., 2015</xref>). The generally accepted definition of AVS is sudden-onset, continuous vertigo lasting over 24 h and accompanied by nausea/vomiting, exercise intolerance, and gait instability; acute unilateral peripheral vestibular lesions are considered the most common cause, including diseases such as acute unilateral vestibulopathy (AUVP)/vestibular neuritis (VN) and sudden deafness with vertigo. EVS refers to recurrent vestibular disorders that are symptomatic during episodes with remission between episodes, and usually includes some transient vestibular system dysfunction (e.g., nystagmus, drop attacks). Signs and symptoms suggestive of cochlear or central nervous system dysfunction may also be present, including diseases such as benign paroxysmal positional vertigo (BPPV), Meni&#x00E8;re&#x2019;s disease (MD), vestibular migraine (VM), transient ischemic attack (TIA), vestibular paroxysmia (VP). CVS is a group of clinical syndromes characterized by chronic dizziness, vertigo, or instability. It lasts from several months to several years, usually with persistent vestibular system dysfunction (visual oscillations, nystagmus, gait instability), including diseases such as bilateral vestibulopathy (BVP) and persistent postural perceptual dizziness (PPPD). The symptoms of CVS can be a gradual progression of deterioration, or they can manifest as persistent symptoms of stable but incomplete recovery from AVS or EVS (<xref ref-type="bibr" rid="B49">Trinidade et al., 2023</xref>).</p>
<p>About 20&#x2013;50% of patients with vertigo and balance disorders have concomitant psychiatric disorders (<xref ref-type="bibr" rid="B36">McKenna et al., 1991</xref>; <xref ref-type="bibr" rid="B5">Best et al., 2009</xref>; <xref ref-type="bibr" rid="B1">Al-Rawashdeh et al., 2019</xref>). Due to the long disease duration, many vertigo patients suffer from anxiety, and concomitant psychiatric disorders such as anxiety and depression have become commonplace among vertigo patients. The prevalence of anxiety and depression among patients with symptoms of vertigo has been reported to be 18 and 11%, respectively (<xref ref-type="bibr" rid="B25">Kim et al., 2016</xref>). <xref ref-type="bibr" rid="B23">Ketola et al. (2007)</xref> found that 20% of a random sample of 100 vertigo patients reported symptoms of depression. <xref ref-type="bibr" rid="B14">Eckhardt-Henn et al. (2003)</xref> conducted neuro-otological examination, vestibular tests, and psychiatric examination and administered evaluations and questionnaires to 129 patients with vertigo accompanied by psychiatric disorders and found a higher prevalence of anxiety (41%) than depression (15%). An analysis of 621 patients in a vertigo clinic by <xref ref-type="bibr" rid="B51">van Leeuwen et al. (2017)</xref> found that the most common secondary diagnosis in patients with vertigo was anxiety (&#x223C;50.1%), which was found primarily in conjunction with peripheral vestibular disorders such as BPPV, vestibular neuritis, and M&#x00E9;ni&#x00E8;re disease. <xref ref-type="bibr" rid="B17">Grunfeld et al. (2003)</xref> found a higher incidence of depression and anxiety among vertigo patients than in normal individuals using the HADS instrument. A cross-sectional study of vertigo patients by <xref ref-type="bibr" rid="B43">Roh et al. (2017)</xref> concluded that the emotional state of vertigo patients may be associated with the persistence of vertigo symptoms and that vertigo-induced psychiatric distress may contribute to a prolonged duration of disease; they recommend timely screening for psychiatric disorders.</p>
<p><xref ref-type="bibr" rid="B8">Brandt and Dieterich (2020)</xref> suggested that damage to the vestibular system is a central factor in the development of mood disorders such as anxiety and depression, and that vestibular hyperfunction (acute excitation or acute vestibular tone imbalance) or hypofunction (chronic vestibular loss) under certain conditions can lead to the development of mood disorders. <xref ref-type="bibr" rid="B15">Furman et al. (2005)</xref> and <xref ref-type="bibr" rid="B16">Goddard et al. (2008)</xref> found that the onset and interaction between vestibular disorders and psychiatric disorders is associated with overlapping central nervous system transmission of the vestibular and mood information pathways. The vestibular nucleus, which controls vertigo, has many nerve fiber projections with mood-related nuclei such as the parabrachial nuclei, the locus coeruleus, and the dorsal raphe nuclei, and also interacts with the frontal lobe, hippocampus, and dentate gyrus. This affects the release of catecholamines (dopamine, norepinephrine), 5-HT, and other neurotransmitters, causing dysfunction in these mood-related regions and affecting the development of anxiety and depression (<xref ref-type="bibr" rid="B15">Furman et al., 2005</xref>; <xref ref-type="bibr" rid="B16">Goddard et al., 2008</xref>; <xref ref-type="bibr" rid="B4">Bednarczuk et al., 2018</xref>; <xref ref-type="bibr" rid="B19">Hilber, 2022</xref>).</p>
<p>By far the most common psychiatric comorbidity in vertigo patients is anxiety and/or depression, which is primarily associated with gender, age, duration of vertigo, frequency of vertigo episodes, and degree of severity of vertigo. The psychiatric state of the patient plays an important role in the prognosis of vertigo disease (<xref ref-type="bibr" rid="B50">Tschan et al., 2011</xref>) but is often neglected by clinicians, which affects the efficacy of vertigo treatment. Both psychological and physical factors must be considered in the clinical treatment of vertigo, and the psychological status of patients warrants increased attention. In addition, intervention with anxiolytic and antidepressant medications and psychotherapy should be considered when determining the best treatment plan. In the present study, we analyzed the general condition and etiology of each type of vestibular syndrome among vertigo outpatients, and also conducted an assessment of anxiety and depression in the patients with the aim of enabling physicians to improve outcomes through more comprehensive communication, psychological guidance, and medication for vertigo patients. The present study analyzed the relationship between vestibular syndrome and anxiety and depression in different genders, age groups, and types of vestibular syndrome.</p>
</sec>
<sec id="S2" sec-type="materials|methods">
<title>2. Materials and methods</title>
<sec id="S2.SS1">
<title>2.1. Source of cases</title>
<p>A cross-sectional study design was adopted. The study was approved by the Ethics Committee. The study population consisted of 386 patients with vertigo who visited the otolaryngology department of the first hospital of China medical university between March 2022 and October 2022. A total of 330 cases were collected after applying the inclusion and exclusion criteria.</p>
</sec>
<sec id="S2.SS2">
<title>2.2. Inclusion criteria</title>
<p>Chief complaint of vertigo or dizziness, meets the diagnostic criteria for each disorder, and relatively complete medical records.</p>
</sec>
<sec id="S2.SS3">
<title>2.3. Exclusion criteria</title>
<p>Patients with major psychiatric disorders or cognitive dysfunction and patients with vertigo clearly caused by other disorders, such as cranial lesions, middle ear lesions, inner ear malformations, internal auditory tract lesions, drug effects, and other medical disorders.</p>
</sec>
<sec id="S2.SS4">
<title>2.4. Diagnostic standards for classification of vertigo</title>
<list list-type="simple">
<list-item>
<label>(1)</label>
<p>Vestibular syndrome was classified into three categories in accordance with the 2015 ICVD (<xref ref-type="bibr" rid="B7">Bisdorff et al., 2015</xref>): AVS, EVS, and CVS.</p>
</list-item>
<list-item>
<label>(2)</label>
<p>Benign paroxysmal positional vertigo was diagnosed in accordance with the 2015 diagnostic criteria for BPPV formulated by the B&#x00E1;r&#x00E1;ny Society (<xref ref-type="bibr" rid="B52">von Brevern et al., 2015</xref>).</p>
</list-item>
<list-item>
<label>(3)</label>
<p>Vestibular migraine was diagnosed in accordance with the 2022 diagnostic criteria for VM formulated by the B&#x00E1;r&#x00E1;ny Society and the International Headache Society (<xref ref-type="bibr" rid="B29">Lempert et al., 2022</xref>).</p>
</list-item>
<list-item>
<label>(4)</label>
<p>Meni&#x00E8;re&#x2019;s disease was diagnosed in accordance with the 2015 diagnostic criteria for MD formulated by the B&#x00E1;r&#x00E1;ny Society, the Japan Society for Equilibrium Research, the European Academy of Otology and Neurotology, the Equilibrium Committee of the American Academy of Otolaryngology-Head and Neck Surgery, and the Korean Balance Society (<xref ref-type="bibr" rid="B21">Ihler et al., 2022</xref>).</p>
</list-item>
<list-item>
<label>(5)</label>
<p>Acute unilateral vestibulopathy/vestibular neuritis were diagnosed in accordance with the 2022 diagnostic criteria for AUVP/VN formulated by the B&#x00E1;r&#x00E1;ny Society (<xref ref-type="bibr" rid="B46">Strupp et al., 2022</xref>).</p>
</list-item>
<list-item>
<label>(6)</label>
<p>Persistent postural perceptual dizziness was diagnosed in accordance with the 2017 consensus document of the committee for the B&#x00E1;r&#x00E1;ny Society (<xref ref-type="bibr" rid="B45">Staab et al., 2017</xref>).</p>
</list-item>
<list-item>
<label>(7)</label>
<p>Sudden hearing loss with vertigo was diagnosed in accordance with the 2019 American Academy of Otolaryngology-Head and Neck Surgery Clinical Practice Guideline for Sudden Hearing Loss (<xref ref-type="bibr" rid="B10">Chandrasekhar et al., 2019</xref>).</p>
</list-item>
<list-item>
<label>(8)</label>
<p>Unilateral vestibular hypofunction (UVH) was diagnosed in accordance with the 2022 Vestibular Rehabilitation for Peripheral Vestibular Hypofunction: An Updated Clinical Practice Guideline From the Academy of Neurologic Physical Therapy of the American Physical Therapy Association (<xref ref-type="bibr" rid="B18">Hall et al., 2022</xref>).</p>
</list-item>
<list-item>
<label>(9)</label>
<p>Bilateral vestibulopathy was diagnosed in accordance with the 2017 diagnostic criteria for BVP developed by the Classification Committee of the B&#x00E1;r&#x00E1;ny Society (<xref ref-type="bibr" rid="B47">Strupp et al., 2017</xref>).</p>
</list-item>
<list-item>
<label>(10)</label>
<p>Unspecified diagnosis: failure to meet the diagnostic criteria due to lack of clinical evidence, including history of suspected VP, posterior circulation ischemic stroke, and TIA.</p>
</list-item>
</list>
</sec>
<sec id="S2.SS5">
<title>2.5. Evaluation of vertigo disorder</title>
<p>The DHI is a widely used self-report questionnaire for patients with dizziness or vertigo that has been translated into 14 languages and is widely validated (<xref ref-type="bibr" rid="B39">Mutlu and Serbetcioglu, 2013</xref>). The DHI consists of 25 items and 4 measurements: the total score and 3 sub-scores (emotional subdomain, DHI-E; functional subdomain, DHI-F; physical subdomain, DHI-P). The total DHI score ranges between 0 and 100 and is used to holistically assess the subjective severity of vertigo symptoms (mild, 0&#x2013;30; moderate, 31&#x2013;60; severe, &#x003E;60).</p>
</sec>
<sec id="S2.SS6">
<title>2.6. Psychological evaluation</title>
<p>The GAD-7 is a simple and effective assessment tool for identifying generalized anxiety disorder and has good sensitivity and specificity for screening anxiety (89% sensitivity, 82% specificity) when the GAD-7 score is &#x2265;10 (<xref ref-type="bibr" rid="B44">Spitzer et al., 2006</xref>). Therefore, a GAD-7 score &#x2265;10 was defined as anxiety in this study. GAD-7 scores can be divided into three ranges: 5&#x2013;9, 10&#x2013;14, and 15&#x2013;21, representing mild, moderate, and severe anxiety disorder, respectively.</p>
<p>The PHQ-9 is an important tool for assessing depression and its severity and is widely used for the screening of psychiatric disorders. A score of 10 or more exhibits good sensitivity and specificity (88% sensitivity, 85% specificity) (<xref ref-type="bibr" rid="B30">Levis et al., 2019</xref>, <xref ref-type="bibr" rid="B31">2020</xref>). Therefore, a PHQ-9 score &#x2265;10 was defined as depression in this study. PHQ-9 scores can be divided into four ranges: 5&#x2013;9, 10&#x2013;14, 15&#x2013;19, and 20&#x2013;27, representing mild, moderate, moderate-severe, and major depression, respectively.</p>
</sec>
<sec id="S2.SS7">
<title>2.7. Case data collection and processing</title>
<p>Collected information on the patient&#x2019;s general condition, type of vertigo symptoms, duration, precipitating factors, past medical history, concomitant symptoms, ancillary examinations, and disease diagnosis.</p>
<p>Under the guidance of specialists, patients completed the DHI questionnaire, the GAD-7 anxiety screening scale, and the PHQ-9 depression screening scale.</p>
<p>Two independent researchers reviewed and validated the completed questionnaires and entered the collected and organized data into the Epidate 3.1 database.</p>
</sec>
<sec id="S2.SS8">
<title>2.8. Data analysis</title>
<p>Data were imported into SPSS 22.0 statistical software for analysis. Descriptive statistic included mean and standard deviation (SD), and proportion. The <italic>t</italic>-test were used for analyzing measurement data, and the chi-square test and fisher&#x2019;s exact test were used for analyzing count data. The relationships between influencing factors were analyzed using multivariate ordered logistic regression analysis. Differences with <italic>p</italic> &#x003C; 0.05 were considered statistically significant.</p>
</sec>
</sec>
<sec id="S3" sec-type="results">
<title>3. Results</title>
<p>The baseline characteristics of the vertigo patients are shown in <xref ref-type="table" rid="T1">Table 1</xref>.</p>
<table-wrap position="float" id="T1">
<label>TABLE 1</label>
<caption><p>Clinical data of participants with vestibular disorder.</p></caption>
<table cellspacing="5" cellpadding="5" frame="box" rules="all">
<thead>
<tr>
<td valign="top" align="left" style="color:#ffffff;background-color: #7f8080;">Characteristic</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">Full sample (<italic>n</italic> = 330)</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">AVS (<italic>n</italic> = 42)</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">EVS (<italic>n</italic> = 236)</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">CVS (<italic>n</italic> = 52)</td>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left" colspan="5" style="background-color: #dcdcdc;"><bold>Age</bold></td>
</tr>
<tr>
<td valign="top" align="left">Average age<xref ref-type="table-fn" rid="t1fnb"><sup>b</sup></xref></td>
<td valign="top" align="center">53.18 &#x00B1; 14.40</td>
<td valign="top" align="center">53.71 &#x00B1; 15.18</td>
<td valign="top" align="center">52.26 &#x00B1; 14.95</td>
<td valign="top" align="center">56.94 &#x00B1; 9.87</td>
</tr>
<tr>
<td valign="top" align="left">&#x003C;60<xref ref-type="table-fn" rid="t1fna"><sup>a</sup></xref></td>
<td valign="top" align="center">205 (62.12)</td>
<td valign="top" align="center">24 (57.14)</td>
<td valign="top" align="center">151 (63.98)</td>
<td valign="top" align="center">30 (57.69)</td>
</tr>
<tr>
<td valign="top" align="left">&#x2265;60<xref ref-type="table-fn" rid="t1fna"><sup>a</sup></xref></td>
<td valign="top" align="center">125 (37.88)</td>
<td valign="top" align="center">18 (42.86)</td>
<td valign="top" align="center">85 (36.02)</td>
<td valign="top" align="center">22 (42.31)</td>
</tr>
<tr>
<td valign="top" align="left" colspan="5" style="background-color: #dcdcdc;"><bold>Gender<xref ref-type="table-fn" rid="t1fna"><sup>a</sup></xref></bold></td>
</tr>
<tr>
<td valign="top" align="left">Male</td>
<td valign="top" align="center">94 (28.48)</td>
<td valign="top" align="center">11 (26.19)</td>
<td valign="top" align="center">68 (28.81)</td>
<td valign="top" align="center">15 (28.85)</td>
</tr>
<tr>
<td valign="top" align="left">Female</td>
<td valign="top" align="center">236 (71.52)</td>
<td valign="top" align="center">31 (73.81)</td>
<td valign="top" align="center">168 (71.19)</td>
<td valign="top" align="center">37 (71.15)</td>
</tr>
<tr>
<td valign="top" align="left" colspan="5" style="background-color: #dcdcdc;"><bold>Complications<xref ref-type="table-fn" rid="t1fna"><sup>a</sup></xref></bold></td>
</tr>
<tr>
<td valign="top" align="left">Deafness</td>
<td valign="top" align="center">58 (17.58)</td>
<td valign="top" align="center">8 (19.05)</td>
<td valign="top" align="center">40 (16.95)</td>
<td valign="top" align="center">10 (19.23)</td>
</tr>
<tr>
<td valign="top" align="left">Tinnitus</td>
<td valign="top" align="center">125 (37.88)</td>
<td valign="top" align="center">16 (38.10)</td>
<td valign="top" align="center">88 (37.29)</td>
<td valign="top" align="center">21 (40.38)</td>
</tr>
<tr>
<td valign="top" align="left">Headache</td>
<td valign="top" align="center">102 (30.91)</td>
<td valign="top" align="center">13 (30.95)</td>
<td valign="top" align="center">65 (27.54)</td>
<td valign="top" align="center">24 (46.15)</td>
</tr>
<tr>
<td valign="top" align="left" colspan="5" style="background-color: #dcdcdc;"><bold>Past history<xref ref-type="table-fn" rid="t1fna"><sup>a</sup></xref></bold></td>
</tr>
<tr>
<td valign="top" align="left">Cardiovascular and cerebrovascular diseases</td>
<td valign="top" align="center">123 (37.27)</td>
<td valign="top" align="center">13 (30.95)</td>
<td valign="top" align="center">85 (36.02)</td>
<td valign="top" align="center">25 (48.08)</td>
</tr>
<tr>
<td valign="top" align="left">Diabetes</td>
<td valign="top" align="center">29 (8.79)</td>
<td valign="top" align="center">8 (19.05)</td>
<td valign="top" align="center">19 (8.05)</td>
<td valign="top" align="center">2 (3.85)</td>
</tr>
<tr>
<td valign="top" align="left">Neurological disorders</td>
<td valign="top" align="center">19 (5.76)</td>
<td valign="top" align="center">3 (7.14)</td>
<td valign="top" align="center">12 (5.08)</td>
<td valign="top" align="center">4 (7.69)</td>
</tr>
<tr>
<td valign="top" align="left">Sleep disturbances</td>
<td valign="top" align="center">33 (10.00)</td>
<td valign="top" align="center">6 (14.29)</td>
<td valign="top" align="center">18 (7.63)</td>
<td valign="top" align="center">9 (17.31)</td>
</tr>
<tr>
<td valign="top" align="left" colspan="5" style="background-color: #dcdcdc;"><bold>GAD-7 (anxiety)<xref ref-type="table-fn" rid="t1fna"><sup>a</sup></xref><xref ref-type="table-fn" rid="t1fns1">&#x002A;</xref></bold></td>
</tr>
<tr>
<td valign="top" align="left">Total &#x003C; 10</td>
<td valign="top" align="center">273 (87.50)</td>
<td valign="top" align="center">36 (92.31)</td>
<td valign="top" align="center">194 (87.39)</td>
<td valign="top" align="center">43 (84.31)</td>
</tr>
<tr>
<td valign="top" align="left">Total &#x2265; 10</td>
<td valign="top" align="center">39 (12.50)</td>
<td valign="top" align="center">3 (7.69)</td>
<td valign="top" align="center">28 (12.61)</td>
<td valign="top" align="center">8 (15.69)</td>
</tr>
<tr>
<td valign="top" align="left" colspan="5" style="background-color: #dcdcdc;"><bold>PHQ-9 (depression)<xref ref-type="table-fn" rid="t1fna"><sup>a</sup></xref><xref ref-type="table-fn" rid="t1fns1">&#x002A;</xref></bold></td>
</tr>
<tr>
<td valign="top" align="left">Total &#x003C; 10</td>
<td valign="top" align="center">271 (88.27)</td>
<td valign="top" align="center">35 (89.74)</td>
<td valign="top" align="center">194 (88.18)</td>
<td valign="top" align="center">42 (87.50)</td>
</tr>
<tr>
<td valign="top" align="left">Total &#x2265; 10</td>
<td valign="top" align="center">36 (11.73)</td>
<td valign="top" align="center">4 (10.26)</td>
<td valign="top" align="center">26 (11.82)</td>
<td valign="top" align="center">6 (12.50)</td>
</tr>
<tr>
<td valign="top" align="left" colspan="5" style="background-color: #dcdcdc;"><bold>Vertigo disorder (DHI)</bold></td>
</tr>
<tr>
<td valign="top" align="left">Total<xref ref-type="table-fn" rid="t1fnb"><sup>b</sup></xref></td>
<td valign="top" align="center">43.36 &#x00B1; 24.69</td>
<td valign="top" align="center">41.52 &#x00B1; 26.28</td>
<td valign="top" align="center">41.74 &#x00B1; 24.09</td>
<td valign="top" align="center">52.33 &#x00B1; 24.11</td>
</tr>
<tr>
<td valign="top" align="left">Physical<xref ref-type="table-fn" rid="t1fnb"><sup>b</sup></xref></td>
<td valign="top" align="center">13.65 &#x00B1; 7.42</td>
<td valign="top" align="center">13.19 &#x00B1; 9.70</td>
<td valign="top" align="center">13.22 &#x00B1; 6.84</td>
<td valign="top" align="center">16.00 &#x00B1; 7.56</td>
</tr>
<tr>
<td valign="top" align="left">Emotional<xref ref-type="table-fn" rid="t1fnb"><sup>b</sup></xref></td>
<td valign="top" align="center">11.68 &#x00B1; 9.71</td>
<td valign="top" align="center">10.00 &#x00B1; 8.33</td>
<td valign="top" align="center">11.37 &#x00B1; 9.71</td>
<td valign="top" align="center">14.46 &#x00B1; 10.38</td>
</tr>
<tr>
<td valign="top" align="left">Functional<xref ref-type="table-fn" rid="t1fnb"><sup>b</sup></xref></td>
<td valign="top" align="center">18.60 &#x00B1; 11.46</td>
<td valign="top" align="center">18.29 &#x00B1; 11.43</td>
<td valign="top" align="center">17.73 &#x00B1; 11.54</td>
<td valign="top" align="center">22.81 &#x00B1; 10.34</td>
</tr>
<tr>
<td valign="top" align="left">Mild<xref ref-type="table-fn" rid="t1fna"><sup>a</sup></xref></td>
<td valign="top" align="center">116 (35.15)</td>
<td valign="top" align="center">19 (45.24)</td>
<td valign="top" align="center">83 (35.17)</td>
<td valign="top" align="center">14 (26.92)</td>
</tr>
<tr>
<td valign="top" align="left">Moderate<xref ref-type="table-fn" rid="t1fna"><sup>a</sup></xref></td>
<td valign="top" align="center">130 (39.39)</td>
<td valign="top" align="center">13 (30.95)</td>
<td valign="top" align="center">101 (42.80)</td>
<td valign="top" align="center">16 (30.77)</td>
</tr>
<tr>
<td valign="top" align="left">Severe<xref ref-type="table-fn" rid="t1fna"><sup>a</sup></xref></td>
<td valign="top" align="center">84 (25.45)</td>
<td valign="top" align="center">10 (23.81)</td>
<td valign="top" align="center">52 (22.03)</td>
<td valign="top" align="center">22 (42.31)</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="t1fna"><p><sup><italic>a</italic></sup><italic>n</italic> (%).</p></fn>
<fn id="t1fnb"><p><sup><italic>b</italic></sup>Mean &#x00B1; SD.</p></fn>
<fn id="t1fns1"><p>&#x002A;The full sample <italic>n</italic> = 330, where the GAD-7 score has 18 missing values and the PHQ-9 score has 23 missing values.</p></fn>
</table-wrap-foot>
</table-wrap>
<p>The mean age of the 330 vertigo patients was 53.18 years (SD: 14.40 years), and 37.88% were aged &#x2265;60 years. The male-to-female ratio of the patients was 1:2.51. Of these patients, 12.50% were anxious and 11.73% were depressed. With respect to syndrome typing, AVS accounted for 12.72%, EVS accounted for 71.52%, and CVS accounted for 15.76%. The mean DHI score was 43.36 (SD: 24.69), with 35.15% of mild disorder, 39.39% of moderate disorder, and 25.45% of severe disorder.</p>
<p>There was no significant differences in age structure, gender ratio, comorbid anxiety, or comorbid depression among patients with AVS, EVS, and CVS (<xref ref-type="table" rid="T2">Table 2</xref>).</p>
<table-wrap position="float" id="T2">
<label>TABLE 2</label>
<caption><p>Age, gender and manifestations of anxiety and depression in patients with different syndromes.</p></caption>
<table cellspacing="5" cellpadding="5" frame="box" rules="all">
<thead>
<tr>
<td valign="top" align="left" style="color:#ffffff;background-color: #7f8080;">Characteristic</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">AVS (<italic>n</italic> = 42)</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">EVS (<italic>n</italic> = 236)</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">CVS (<italic>n</italic> = 52)</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">&#x03C7;<sup>2</sup></td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;"><italic>P</italic></td>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Age</td>
<td/>
<td/>
<td/>
<td valign="top" align="center">1.224</td>
<td valign="top" align="center">0.542</td>
</tr>
<tr>
<td valign="top" align="left">&#x003C;60 (<italic>n</italic> = 205)</td>
<td valign="top" align="center">24 (57.14)</td>
<td valign="top" align="center">151 (63.98)</td>
<td valign="top" align="center">30 (57.69)</td>
<td/>
<td/>
</tr>
<tr>
<td valign="top" align="left">&#x2265;60 (<italic>n</italic> = 125)</td>
<td valign="top" align="center">18 (42.86)</td>
<td valign="top" align="center">85 (36.02)</td>
<td valign="top" align="center">22 (42.31)</td>
<td/>
<td/>
</tr>
<tr>
<td valign="top" align="left">Gender</td>
<td/>
<td/>
<td/>
<td valign="top" align="center">0.124</td>
<td valign="top" align="center">0.940</td>
</tr>
<tr>
<td valign="top" align="left">Male (<italic>n</italic> = 94)</td>
<td valign="top" align="center">11 (26.19)</td>
<td valign="top" align="center">68 (28.81)</td>
<td valign="top" align="center">15 (28.85)</td>
<td/>
<td/>
</tr>
<tr>
<td valign="top" align="left">Female (<italic>n</italic> = 236)</td>
<td valign="top" align="center">31 (73.81)</td>
<td valign="top" align="center">168 (71.19)</td>
<td valign="top" align="center">37 (71.15)</td>
<td/>
<td/>
</tr>
<tr>
<td valign="top" align="left">GAD-7<xref ref-type="table-fn" rid="t2fns1">&#x002A;</xref></td>
<td/>
<td/>
<td/>
<td valign="top" align="center">1.228</td>
<td valign="top" align="center">0.585</td>
</tr>
<tr>
<td valign="top" align="left">Total &#x003C; 10 (<italic>n</italic> = 273)</td>
<td valign="top" align="center">36 (92.31)</td>
<td valign="top" align="center">194 (87.39)</td>
<td valign="top" align="center">43 (84.31)</td>
<td/>
<td/>
</tr>
<tr>
<td valign="top" align="left">Total &#x2265; 10 (<italic>n</italic> = 39)</td>
<td valign="top" align="center">3 (7.69)</td>
<td valign="top" align="center">28 (12.61)</td>
<td valign="top" align="center">8 (15.69)</td>
<td/>
<td/>
</tr>
<tr>
<td valign="top" align="left">PHQ-9<xref ref-type="table-fn" rid="t2fns1">&#x002A;</xref></td>
<td/>
<td/>
<td/>
<td valign="top" align="center">0.130</td>
<td valign="top" align="center">0.961</td>
</tr>
<tr>
<td valign="top" align="left">Total &#x003C; 10 (<italic>n</italic> = 271)</td>
<td valign="top" align="center">35 (89.74)</td>
<td valign="top" align="center">194 (88.18)</td>
<td valign="top" align="center">42 (87.50)</td>
<td/>
<td/>
</tr>
<tr>
<td valign="top" align="left">Total &#x2265; 10 (<italic>n</italic> = 36)</td>
<td valign="top" align="center">4 (10.26)</td>
<td valign="top" align="center">26 (11.82)</td>
<td valign="top" align="center">6 (12.50)</td>
<td/>
<td/>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="t2fns1"><p>&#x002A;In the GAD-7 score, there were 18 missing values in the full sample, 3 missing values in AVS, 14 missing values in EVS, 1 missing value in CVS. In the PHQ-9 score, there were 23 missing values in the full sample, 3 missing values in AVS, 16 missing values in EVS, 4 missing values in CVS.</p></fn>
</table-wrap-foot>
</table-wrap>
<p>The probability of presenting with anxiety and depression did not differ significantly among vertigo patients of different ages and genders (<xref ref-type="table" rid="T3">Tables 3</xref>, <xref ref-type="table" rid="T4">4</xref>).</p>
<table-wrap position="float" id="T3">
<label>TABLE 3</label>
<caption><p>Combined anxiety in patients with vertigo of different ages and genders.</p></caption>
<table cellspacing="5" cellpadding="5" frame="box" rules="all">
<thead>
<tr>
<td valign="top" align="left" rowspan="2" style="color:#ffffff;background-color: #7f8080;"></td>
<td valign="top" align="center" colspan="2" style="color:#ffffff;background-color: #7f8080;">Full sample (<italic>n</italic> = 312)</td>
<td valign="top" align="center" rowspan="2" style="color:#ffffff;background-color: #7f8080;"><italic>P</italic></td>
<td valign="top" align="center" colspan="2" style="color:#ffffff;background-color: #7f8080;">AVS (<italic>n</italic> = 39)</td>
<td valign="top" align="center" rowspan="2" style="color:#ffffff;background-color: #7f8080;"><italic>P</italic></td>
<td valign="top" align="center" colspan="2" style="color:#ffffff;background-color: #7f8080;">EVS (<italic>n</italic> = 222)</td>
<td valign="top" align="center" rowspan="2" style="color:#ffffff;background-color: #7f8080;"><italic>P</italic></td>
<td valign="top" align="center" colspan="2" style="color:#ffffff;background-color: #7f8080;">CVS (<italic>n</italic> = 51)</td>
<td valign="top" align="center" rowspan="2" style="color:#ffffff;background-color: #7f8080;"><italic>P</italic></td>
</tr>
<tr>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">GAD7 &#x003C; 10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">&#x2265;10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">GAD7 &#x003C; 10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">&#x2265;10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">GAD7 &#x003C; 10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">&#x2265;10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">GAD7 &#x003C; 10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">&#x2265;10</td>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Age</td>
<td/>
<td/>
<td valign="top" align="center">0.894</td>
<td/>
<td/>
<td valign="top" align="center">1.000</td>
<td/>
<td/>
<td valign="top" align="center">0.945</td>
<td/>
<td/>
<td valign="top" align="center">1.000</td>
</tr>
<tr>
<td valign="top" align="left">&#x003C;60</td>
<td valign="top" align="center">172 (63.00)</td>
<td valign="top" align="center">25 (64.10)</td>
<td/>
<td valign="top" align="center">22 (61.11)</td>
<td valign="top" align="center">2 (66.67)</td>
<td/>
<td valign="top" align="center">126 (64.95)</td>
<td valign="top" align="center">18 (64.29)</td>
<td/>
<td valign="top" align="center">24 (55.81)</td>
<td valign="top" align="center">5 (62.50)</td>
<td/>
</tr>
<tr>
<td valign="top" align="left">&#x2265;60</td>
<td valign="top" align="center">101 (37.00)</td>
<td valign="top" align="center">14 (35.90)</td>
<td/>
<td valign="top" align="center">14 (38.89)</td>
<td valign="top" align="center">1 (33.33)</td>
<td/>
<td valign="top" align="center">68 (35.05)</td>
<td valign="top" align="center">10 (35.71)</td>
<td/>
<td valign="top" align="center">19 (44.19)</td>
<td valign="top" align="center">3 (37.50)</td>
<td/>
</tr>
<tr>
<td valign="top" align="left">Gender</td>
<td/>
<td/>
<td valign="top" align="center">0.704</td>
<td/>
<td/>
<td valign="top" align="center">0.127</td>
<td/>
<td/>
<td valign="top" align="center">0.930</td>
<td/>
<td/>
<td valign="top" align="center">1.000</td>
</tr>
<tr>
<td valign="top" align="left">Male</td>
<td valign="top" align="center">76 (27.84)</td>
<td valign="top" align="center">12 (30.77)</td>
<td/>
<td valign="top" align="center">7 (19.44)</td>
<td valign="top" align="center">2 (66.67)</td>
<td/>
<td valign="top" align="center">57 (29.38)</td>
<td valign="top" align="center">8 (28.57)</td>
<td/>
<td valign="top" align="center">12 (27.91)</td>
<td valign="top" align="center">2 (25.00)</td>
<td/>
</tr>
<tr>
<td valign="top" align="left">Female</td>
<td valign="top" align="center">197 (72.16)</td>
<td valign="top" align="center">27 (69.23)</td>
<td/>
<td valign="top" align="center">29 (80.56)</td>
<td valign="top" align="center">1 (33.33)</td>
<td/>
<td valign="top" align="center">137 (70.62)</td>
<td valign="top" align="center">20 (71.43)</td>
<td/>
<td valign="top" align="center">31 (72.09)</td>
<td valign="top" align="center">6 (75.00)</td>
<td/>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn><p>Chi-square test was used to analysis for full sample and EVS, and Fisher&#x2019;s exact test was used to analysis for AVS and CVS.</p></fn>
</table-wrap-foot>
</table-wrap>
<table-wrap position="float" id="T4">
<label>TABLE 4</label>
<caption><p>Combined depression in patients with vertigo of different ages and genders.</p></caption>
<table cellspacing="5" cellpadding="5" frame="box" rules="all">
<thead>
<tr>
<td valign="top" align="left" rowspan="2" style="color:#ffffff;background-color: #7f8080;"></td>
<td valign="top" align="center" colspan="2" style="color:#ffffff;background-color: #7f8080;">Full sample (<italic>n</italic> = 307)</td>
<td valign="top" align="center" rowspan="2" style="color:#ffffff;background-color: #7f8080;"><italic>P</italic></td>
<td valign="top" align="center" colspan="2" style="color:#ffffff;background-color: #7f8080;">AVS (<italic>n</italic> = 39)</td>
<td valign="top" align="center" rowspan="2" style="color:#ffffff;background-color: #7f8080;"><italic>P</italic></td>
<td valign="top" align="center" colspan="2" style="color:#ffffff;background-color: #7f8080;">EVS (<italic>n</italic> = 220)</td>
<td valign="top" align="center" rowspan="2" style="color:#ffffff;background-color: #7f8080;"><italic>P</italic></td>
<td valign="top" align="center" colspan="2" style="color:#ffffff;background-color: #7f8080;">CVS (<italic>n</italic> = 48)</td>
<td valign="top" align="center" rowspan="2" style="color:#ffffff;background-color: #7f8080;"><italic>P</italic></td>
</tr>
<tr>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">PHQ9 &#x003C; 10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">&#x2265;10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">PHQ9 &#x003C; 10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">&#x2265;10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">PHQ9 &#x003C; 10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">&#x2265;10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">PHQ9 &#x003C; 10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">&#x2265;10</td>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Age</td>
<td/>
<td/>
<td valign="top" align="center">0.645</td>
<td/>
<td/>
<td valign="top" align="center">1.000</td>
<td/>
<td/>
<td valign="top" align="center">0.630</td>
<td/>
<td/>
<td valign="top" align="center">1.000</td>
</tr>
<tr>
<td valign="top" align="left">&#x003C;60</td>
<td valign="top" align="center">170 (62.73)</td>
<td valign="top" align="center">24 (66.67)</td>
<td/>
<td valign="top" align="center">21 (60.00)</td>
<td valign="top" align="center">3 (75.00)</td>
<td/>
<td valign="top" align="center">125 (64.43)</td>
<td valign="top" align="center">18 (69.23)</td>
<td/>
<td valign="top" align="center">24 (57.14)</td>
<td valign="top" align="center">3 (50.00)</td>
<td/>
</tr>
<tr>
<td valign="top" align="left">&#x2265;60</td>
<td valign="top" align="center">101 (37.27)</td>
<td valign="top" align="center">12 (33.33)</td>
<td/>
<td valign="top" align="center">14 (40.00)</td>
<td valign="top" align="center">1 (25.00)</td>
<td/>
<td valign="top" align="center">69 (35.57)</td>
<td valign="top" align="center">8 (30.77)</td>
<td/>
<td valign="top" align="center">18 (42.86)</td>
<td valign="top" align="center">3 (50.00)</td>
<td/>
</tr>
<tr>
<td valign="top" align="left">Gender</td>
<td/>
<td/>
<td valign="top" align="center">0.718</td>
<td/>
<td/>
<td valign="top" align="center">1.000</td>
<td/>
<td/>
<td valign="top" align="center">0.798</td>
<td/>
<td/>
<td valign="top" align="center">1.000</td>
</tr>
<tr>
<td valign="top" align="left">Male</td>
<td valign="top" align="center">75 (27.68)</td>
<td valign="top" align="center">11 (30.56)</td>
<td/>
<td valign="top" align="center">8 (22.86)</td>
<td valign="top" align="center">1 (25.00)</td>
<td/>
<td valign="top" align="center">55 (28.35)</td>
<td valign="top" align="center">8 (30.77)</td>
<td/>
<td valign="top" align="center">12 (28.57)</td>
<td valign="top" align="center">2 (33.33)</td>
<td/>
</tr>
<tr>
<td valign="top" align="left">Female</td>
<td valign="top" align="center">196 (72.32)</td>
<td valign="top" align="center">25 (69.44)</td>
<td/>
<td valign="top" align="center">27 (77.14)</td>
<td valign="top" align="center">3 (75.00)</td>
<td/>
<td valign="top" align="center">139 (71.65)</td>
<td valign="top" align="center">18 (69.23)</td>
<td/>
<td valign="top" align="center">30 (71.43)</td>
<td valign="top" align="center">4 (66.67)</td>
<td/>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn><p>Chi-square test was used to analysis for full sample and EVS, and Fisher&#x2019;s exact test was used to analysis for AVS and CVS.</p></fn>
</table-wrap-foot>
</table-wrap>
<p>When patients with various forms of vertigo were analyzed, a significant difference in the total DHI score among all patients was found between those with and without anxiety (<italic>P</italic> &#x003C; 0.001), and there were differences in physical symptoms (<italic>P</italic> = 0.020), emotional state (<italic>P</italic> &#x003C; 0.001), and social functioning (<italic>P</italic> &#x003C; 0.001). In EVS, there was a significant difference in total DHI score between those with and without anxiety (<italic>P</italic> &#x003C; 0.001), and there were differences in physical symptoms (<italic>P</italic> = 0.021), emotional state (<italic>P</italic> &#x003C; 0.001), and social functioning (<italic>P</italic> &#x003C; 0.001). In CVS, there was a significant difference in total DHI score between those with and without anxiety (<italic>P</italic> = 0.018), which was primarily manifested in a difference in emotional state (<italic>P</italic> = 0.023) (<xref ref-type="table" rid="T5">Table 5</xref>).</p>
<table-wrap position="float" id="T5">
<label>TABLE 5</label>
<caption><p>Differences of anxiety in various forms of vertigo disorder.</p></caption>
<table cellspacing="5" cellpadding="5" frame="box" rules="all">
<thead>
<tr>
<td valign="top" align="left" rowspan="2" style="color:#ffffff;background-color: #7f8080;"></td>
<td valign="top" align="center" colspan="2" style="color:#ffffff;background-color: #7f8080;">Full sample (<italic>n</italic> = 312)</td>
<td valign="top" align="center" rowspan="2" style="color:#ffffff;background-color: #7f8080;"><italic>P</italic></td>
<td valign="top" align="center" colspan="2" style="color:#ffffff;background-color: #7f8080;">AVS (<italic>n</italic> = 39)</td>
<td valign="top" align="center" rowspan="2" style="color:#ffffff;background-color: #7f8080;"><italic>P</italic></td>
<td valign="top" align="center" colspan="2" style="color:#ffffff;background-color: #7f8080;">EVS (<italic>n</italic> = 222)</td>
<td valign="top" align="center" rowspan="2" style="color:#ffffff;background-color: #7f8080;"><italic>P</italic></td>
<td valign="top" align="center" colspan="2" style="color:#ffffff;background-color: #7f8080;">CVS (<italic>n</italic> = 51)</td>
<td valign="top" align="center" rowspan="2" style="color:#ffffff;background-color: #7f8080;"><italic>P</italic></td>
</tr>
<tr>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">GAD7 &#x003C; 10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">&#x2265;10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">GAD7 &#x003C; 10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">&#x2265;10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">GAD7 &#x003C; 10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">&#x2265;10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">GAD7 &#x003C; 10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">&#x2265;10</td>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">DHI Total</td>
<td valign="top" align="center">40.99 &#x00B1; 24.27</td>
<td valign="top" align="center">61.42 &#x00B1; 22.75</td>
<td valign="top" align="center"><bold>&#x003C;0.001</bold></td>
<td valign="top" align="center">41.67 &#x00B1; 26.84</td>
<td valign="top" align="center">56.67 &#x00B1; 33.01</td>
<td valign="top" align="center">0.365</td>
<td valign="top" align="center">39.13 &#x00B1; 23.57</td>
<td valign="top" align="center">59.11 &#x00B1; 22.80</td>
<td valign="top" align="center"><bold>&#x003C;0.001</bold></td>
<td valign="top" align="center">48.93 &#x00B1; 24.10</td>
<td valign="top" align="center">71.00 &#x00B1; 18.94</td>
<td valign="top" align="center"><bold>0.018</bold></td>
</tr>
<tr>
<td valign="top" align="left">Physical</td>
<td valign="top" align="center">13.37 &#x00B1; 7.48</td>
<td valign="top" align="center">16.36 &#x00B1; 7.33</td>
<td valign="top" align="center"><bold>0.020</bold></td>
<td valign="top" align="center">13.83 &#x00B1; 10.09</td>
<td valign="top" align="center">10.00 &#x00B1; 9.17</td>
<td valign="top" align="center">0.529</td>
<td valign="top" align="center">12.85 &#x00B1; 6.77</td>
<td valign="top" align="center">16.07 &#x00B1; 7.35</td>
<td valign="top" align="center"><bold>0.021</bold></td>
<td valign="top" align="center">15.35 &#x00B1; 7.84</td>
<td valign="top" align="center">19.75 &#x00B1; 5.29</td>
<td valign="top" align="center">0.135</td>
</tr>
<tr>
<td valign="top" align="left">Emotional</td>
<td valign="top" align="center">10.51 &#x00B1; 9.25</td>
<td valign="top" align="center">20.36 &#x00B1; 9.41</td>
<td valign="top" align="center"><bold>&#x003C;0.001</bold></td>
<td valign="top" align="center">9.67 &#x00B1; 7.89</td>
<td valign="top" align="center">18.67 &#x00B1; 12.22</td>
<td valign="top" align="center">0.075</td>
<td valign="top" align="center">10.05 &#x00B1; 9.29</td>
<td valign="top" align="center">20.00 &#x00B1; 9.11</td>
<td valign="top" align="center"><bold>&#x003C;0.001</bold></td>
<td valign="top" align="center">13.26 &#x00B1; 9.82</td>
<td valign="top" align="center">22.25 &#x00B1; 10.61</td>
<td valign="top" align="center"><bold>0.023</bold></td>
</tr>
<tr>
<td valign="top" align="left">Functional</td>
<td valign="top" align="center">17.55 &#x00B1; 11.37</td>
<td valign="top" align="center">26.15 &#x00B1; 10.14</td>
<td valign="top" align="center"><bold>&#x003C;0.001</bold></td>
<td valign="top" align="center">18.17 &#x00B1; 11.55</td>
<td valign="top" align="center">26.67 &#x00B1; 12.86</td>
<td valign="top" align="center">0.231</td>
<td valign="top" align="center">16.55 &#x00B1; 11.35</td>
<td valign="top" align="center">25.29 &#x00B1; 10.92</td>
<td valign="top" align="center"><bold>&#x003C;0.001</bold></td>
<td valign="top" align="center">21.53 &#x00B1; 10.66</td>
<td valign="top" align="center">29.00 &#x00B1; 6.23</td>
<td valign="top" align="center">0.062</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn><p>The bold values indicate mean <italic>p</italic> &#x003C; 0.05, these values were considered statistically significant.</p></fn>
</table-wrap-foot>
</table-wrap>
<p>When patients with various forms of vertigo were analyzed, a significant difference in the total DHI score among all patients was found between those with and without depression (<italic>P</italic> &#x003C; 0.001), and there were differences in physical symptoms (<italic>P</italic> = 0.006), emotional state (<italic>P</italic> &#x003C; 0.001), and social functioning (<italic>P</italic> &#x003C; 0.001). In EVS, there was a significant difference in total DHI score between those with and without depression (<italic>P</italic> = 0.008), and there were differences in physical symptoms (<italic>P</italic> = 0.030), emotional state (<italic>P</italic> = 0.041), and social functioning (<italic>P</italic> = 0.030). In AVS, there was a significant difference in total DHI score between those with and without depression (<italic>P</italic> = 0.005), which was primarily manifested in difference in emotional state (<italic>P</italic> &#x003C; 0.001) and social functioning (<italic>P</italic> = 0.006) (<xref ref-type="table" rid="T6">Table 6</xref>).</p>
<table-wrap position="float" id="T6">
<label>TABLE 6</label>
<caption><p>Differences of depression in various forms of vertigo disorder.</p></caption>
<table cellspacing="5" cellpadding="5" frame="box" rules="all">
<thead>
<tr>
<td valign="top" align="left" rowspan="2" style="color:#ffffff;background-color: #7f8080;"></td>
<td valign="top" align="center" colspan="2" style="color:#ffffff;background-color: #7f8080;">Full sample (<italic>n</italic> = 307)</td>
<td valign="top" align="center" rowspan="2" style="color:#ffffff;background-color: #7f8080;"><italic>P</italic></td>
<td valign="top" align="center" colspan="2" style="color:#ffffff;background-color: #7f8080;">AVS (<italic>n</italic> = 39)</td>
<td valign="top" align="center" rowspan="2" style="color:#ffffff;background-color: #7f8080;"><italic>P</italic></td>
<td valign="top" align="center" colspan="2" style="color:#ffffff;background-color: #7f8080;">EVS (<italic>n</italic> = 220)</td>
<td valign="top" align="center" rowspan="2" style="color:#ffffff;background-color: #7f8080;"><italic>P</italic></td>
<td valign="top" align="center" colspan="2" style="color:#ffffff;background-color: #7f8080;">CVS (<italic>n</italic> = 48)</td>
<td valign="top" align="center" rowspan="2" style="color:#ffffff;background-color: #7f8080;"><italic>P</italic></td>
</tr>
<tr>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">PHQ9 &#x003C; 10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">&#x2265;10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">PHQ9 &#x003C; 10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">&#x2265;10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">PHQ9 &#x003C; 10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">&#x2265;10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">PHQ9 &#x003C; 10</td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;">&#x2265;10</td>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">DHI Total</td>
<td valign="top" align="center">41.28 &#x00B1; 24.62</td>
<td valign="top" align="center">58.72 &#x00B1; 23.69</td>
<td valign="top" align="center"><bold>&#x003C;0.001</bold></td>
<td valign="top" align="center">38.86 &#x00B1; 25.59</td>
<td valign="top" align="center">77.50 &#x00B1; 11.36</td>
<td valign="top" align="center"><bold>0.005</bold></td>
<td valign="top" align="center">39.60 &#x00B1; 24.09</td>
<td valign="top" align="center">53.00 &#x00B1; 23.67</td>
<td valign="top" align="center"><bold>0.008</bold></td>
<td valign="top" align="center">51.20 &#x00B1; 24.50</td>
<td valign="top" align="center">71.00 &#x00B1; 20.39</td>
<td valign="top" align="center">0.066</td>
</tr>
<tr>
<td valign="top" align="left">Physical</td>
<td valign="top" align="center">13.32 &#x00B1; 7.57</td>
<td valign="top" align="center">17.00 &#x00B1; 6.30</td>
<td valign="top" align="center"><bold>0.006</bold></td>
<td valign="top" align="center">12.80 &#x00B1; 10.07</td>
<td valign="top" align="center">20.00 &#x00B1; 6.73</td>
<td valign="top" align="center">0.174</td>
<td valign="top" align="center">12.79 &#x00B1; 6.89</td>
<td valign="top" align="center">15.92 &#x00B1; 6.49</td>
<td valign="top" align="center"><bold>0.030</bold></td>
<td valign="top" align="center">16.19 &#x00B1; 7.74</td>
<td valign="top" align="center">19.67 &#x00B1; 4.27</td>
<td valign="top" align="center">0.290</td>
</tr>
<tr>
<td valign="top" align="left">Emotional</td>
<td valign="top" align="center">10.92 &#x00B1; 9.67</td>
<td valign="top" align="center">17.00 &#x00B1; 9.90</td>
<td valign="top" align="center"><bold>&#x003C;0.001</bold></td>
<td valign="top" align="center">8.91 &#x00B1; 7.25</td>
<td valign="top" align="center">23.00 &#x00B1; 8.25</td>
<td valign="top" align="center"><bold>&#x003C;0.001</bold></td>
<td valign="top" align="center">10.64 &#x00B1; 9.86</td>
<td valign="top" align="center">14.85 &#x00B1; 9.25</td>
<td valign="top" align="center"><bold>0.041</bold></td>
<td valign="top" align="center">13.90 &#x00B1; 10.10</td>
<td valign="top" align="center">22.33 &#x00B1; 11.41</td>
<td valign="top" align="center">0.066</td>
</tr>
<tr>
<td valign="top" align="left">Functional</td>
<td valign="top" align="center">17.81 &#x00B1; 11.52</td>
<td valign="top" align="center">24.61 &#x00B1; 10.46</td>
<td valign="top" align="center"><bold>&#x003C;0.001</bold></td>
<td valign="top" align="center">17.14 &#x00B1; 11.15</td>
<td valign="top" align="center">33.50 &#x00B1; 1.92</td>
<td valign="top" align="center"><bold>0.006</bold></td>
<td valign="top" align="center">16.96 &#x00B1; 11.61</td>
<td valign="top" align="center">22.23 &#x00B1; 10.90</td>
<td valign="top" align="center"><bold>0.030</bold></td>
<td valign="top" align="center">22.29 &#x00B1; 10.54</td>
<td valign="top" align="center">29.00 &#x00B1; 7.35</td>
<td valign="top" align="center">0.140</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn><p>The bold values indicate mean <italic>p</italic> &#x003C; 0.05, these values were considered statistically significant.</p></fn>
</table-wrap-foot>
</table-wrap>
<p>The relationship between each influencing factor and the severity of vertigo was determined using multivariate ordered logistic regression analysis (DHI &#x201C;mild/moderate/severe&#x201D; severity was the ordered classification outcome, model fit <italic>p</italic> &#x003C; 0.001 indicated effective establishment of the regression equation, test of parallel lines <italic>p</italic> = 0.776 &#x003E; 0.05 indicated equivalence to mild/moderate/severe). Age &#x2265;60 or &#x003C;60 years and gender had no statistically significant effects on the severity of vertigo.</p>
<p>Among all patients, patients with anxiety were 4.65 times more likely to have severe vertigo than patients without anxiety, and patients with depression were 3.49 times more likely to have severe vertigo than patients without depression.</p>
<p>Among AVS patients, anxiety and depression had no statistically significant effect on the severity of vertigo. Among EVS patients, patients with anxiety were 4.42 times more likely to have severe vertigo than patients without anxiety, and patients with depression were 3.58 times more likely to have severe vertigo than patients without depression. Among CVS patients, patients with anxiety were 5.83 times more likely to have severe vertigo than patients without anxiety, and depression had no statistically significant effect on the severity of vertigo (<xref ref-type="table" rid="T7">Table 7</xref> and <xref ref-type="fig" rid="F1">Figure 1</xref>).</p>
<table-wrap position="float" id="T7">
<label>TABLE 7</label>
<caption><p>Influence of various factors on vertigo degree in patients with different vestibular syndromes.</p></caption>
<table cellspacing="5" cellpadding="5" frame="box" rules="all">
<thead>
<tr>
<td valign="top" align="left" rowspan="2" style="color:#ffffff;background-color: #7f8080;"></td>
<td valign="top" align="center" colspan="2" style="color:#ffffff;background-color: #7f8080;">Full sample (<italic>n</italic> = 330)</td>
<td valign="top" align="center" colspan="2" style="color:#ffffff;background-color: #7f8080;">AVS (<italic>n</italic> = 42)</td>
<td valign="top" align="center" colspan="2" style="color:#ffffff;background-color: #7f8080;">EVS (<italic>n</italic> = 236)</td>
<td valign="top" align="center" colspan="2" style="color:#ffffff;background-color: #7f8080;">CVS (<italic>n</italic> = 52)</td>
</tr>
<tr>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;"><italic>OR</italic></td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;"><italic>P</italic></td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;"><italic>OR</italic></td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;"><italic>P</italic></td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;"><italic>OR</italic></td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;"><italic>P</italic></td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;"><italic>OR</italic></td>
<td valign="top" align="center" style="color:#ffffff;background-color: #7f8080;"><italic>P</italic></td>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Age</td>
<td valign="top" align="center">0.999 (0.66, 1.51)</td>
<td valign="top" align="center">0.996</td>
<td valign="top" align="center">0.63 (0.20, 1.997)</td>
<td valign="top" align="center">0.435</td>
<td valign="top" align="center">1.05 (0.64, 1.72)</td>
<td valign="top" align="center">0.851</td>
<td valign="top" align="center">1.13 (0.41, 3.14)</td>
<td valign="top" align="center">0.809</td>
</tr>
<tr>
<td valign="top" align="left">Gender</td>
<td valign="top" align="center">1.14 (0.73, 1.78)</td>
<td valign="top" align="center">0.560</td>
<td valign="top" align="center">1.63 (0.44, 6.07)</td>
<td valign="top" align="center">0.463</td>
<td valign="top" align="center">1.29 (0.76, 2.18)</td>
<td valign="top" align="center">0.346</td>
<td valign="top" align="center">0.60 (0.19, 1.85)</td>
<td valign="top" align="center">0.373</td>
</tr>
<tr>
<td valign="top" align="left">GAD-7</td>
<td valign="top" align="center"><bold>4.65 (2.40, 9.03)</bold></td>
<td valign="top" align="center"><bold>&#x003C;0.001</bold></td>
<td valign="top" align="center">4.45 (0.44, 45.19)</td>
<td valign="top" align="center">0.206</td>
<td valign="top" align="center"><bold>4.42 (2.04, 9.58)</bold></td>
<td valign="top" align="center"><bold>&#x003C;0.001</bold></td>
<td valign="top" align="center"><bold>5.83 (1.03, 33.04)</bold></td>
<td valign="top" align="center"><bold>0.047</bold></td>
</tr>
<tr>
<td valign="top" align="left">PHQ-9</td>
<td valign="top" align="center"><bold>3.49 (1.79, 6.82)</bold></td>
<td valign="top" align="center"><bold>&#x003C;0.001</bold></td>
<td valign="top" align="center">&#x2212;<sup>#</sup></td>
<td valign="top" align="center">&#x2212;<sup>#</sup></td>
<td valign="top" align="center"><bold>3.58 (1.19, 5.57)</bold></td>
<td valign="top" align="center"><bold>0.016</bold></td>
<td valign="top" align="center">3.32 (0.54, 20.53)</td>
<td valign="top" align="center">0.198</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn><p><sup>#</sup>The value is abnormality. The bold values indicate mean <italic>p</italic> &#x003C; 0.05, these values were considered statistically significant.</p></fn>
</table-wrap-foot>
</table-wrap>
<fig id="F1" position="float">
<label>FIGURE 1</label>
<caption><p>Influence of age, gender, anxiety, and depression on vertigo degree.</p></caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fnagi-15-1208392-g001.tif"/>
</fig>
</sec>
<sec id="S4" sec-type="discussion">
<title>4. Discussion</title>
<p>In recent years, comorbid psychological and physical symptoms in vertigo patients has gained interest among clinicians. The coexistence of vestibular and psychiatric disorders has been repeatedly described in the literature (<xref ref-type="bibr" rid="B5">Best et al., 2009</xref>; <xref ref-type="bibr" rid="B28">Lahmann et al., 2015</xref>; <xref ref-type="bibr" rid="B32">Limburg et al., 2018</xref>; <xref ref-type="bibr" rid="B9">Bronstein and Dieterich, 2019</xref>; <xref ref-type="bibr" rid="B48">Toupet et al., 2019</xref>; <xref ref-type="bibr" rid="B41">&#x00D6;zdilek et al., 2019</xref>; <xref ref-type="bibr" rid="B26">K&#x0131;sabay Ak et al., 2022</xref>), with anxiety and depression cited as the primary factors. Many studies have reported a significantly higher prevalence of comorbid peripheral vertigo and anxiety and depression than in the general population (<xref ref-type="bibr" rid="B8">Brandt and Dieterich, 2020</xref>). <xref ref-type="bibr" rid="B25">Kim et al. (2016)</xref> found a higher prevalence of psychiatric disorders such as depression and generalized anxiety in patients with BPPV compared to the general population (<xref ref-type="bibr" rid="B27">Kozak et al., 2018</xref>). A prospective study by <xref ref-type="bibr" rid="B41">&#x00D6;zdilek et al. (2019)</xref> showed that Beck Anxiety Inventory (BAI) scores were higher in patients with BPPV than in control individuals, indicating higher levels of anxiety in patients with BPPV. Psychological symptoms such as anxiety and depression are common in patients with vertigo regardless of its primary cause (<xref ref-type="bibr" rid="B24">Ketola et al., 2015</xref>; <xref ref-type="bibr" rid="B54">Zhai et al., 2016</xref>; <xref ref-type="bibr" rid="B32">Limburg et al., 2018</xref>; <xref ref-type="bibr" rid="B3">Balci and Akdal, 2020</xref>; <xref ref-type="bibr" rid="B26">K&#x0131;sabay Ak et al., 2022</xref>). Our study suggests that the association between vertigo and anxiety and depression is very strong. In our sample, 12.50% of vertigo patients had comorbid anxiety and 11.73% of vertigo patients had comorbid depression.</p>
<p>The potential mechanisms underlying the connection between vertigo and psychiatric disorders remain unclear. Neural circuits associated with the vestibular nervous system and psychiatric disorders such as anxiety and depression have been found to be interrelated (<xref ref-type="bibr" rid="B4">Bednarczuk et al., 2018</xref>; <xref ref-type="bibr" rid="B9">Bronstein and Dieterich, 2019</xref>; <xref ref-type="bibr" rid="B12">Decker et al., 2019</xref>; <xref ref-type="bibr" rid="B48">Toupet et al., 2019</xref>; <xref ref-type="bibr" rid="B8">Brandt and Dieterich, 2020</xref>), and there is growing evidence to support that psychological factors influence vertigo episodes and response to treatment in a complex manner (<xref ref-type="bibr" rid="B6">Bigelow et al., 2016</xref>; <xref ref-type="bibr" rid="B53">Wei et al., 2018</xref>; <xref ref-type="bibr" rid="B8">Brandt and Dieterich, 2020</xref>; <xref ref-type="bibr" rid="B40">Ogihara et al., 2022</xref>). Two large-scale, population-based retrospective studies have confirmed that patients with anxiety and depression have a higher risk of developing BPPV than healthy individuals, with hazard ratios of 2.52 and 1.79, respectively (<xref ref-type="bibr" rid="B11">Chen et al., 2016</xref>; <xref ref-type="bibr" rid="B20">Hsu et al., 2019</xref>). <xref ref-type="bibr" rid="B9">Bronstein and Dieterich (2019)</xref> found that the long-term prognostic outcome of vestibular neuritis is largely dependent on psychophysiological and psychological factors. <xref ref-type="bibr" rid="B40">Ogihara et al. (2022)</xref> suggest that psychological factors may influence the rehabilitation of vestibular balance disorders, leading to long-term vertigo or dizziness. Anxiety and depression can significantly reduce the efficacy of the initial canalith repositioning treatment in patients with BPPV and lead to a pronounced risk of relapse within 6 months after treatment (<xref ref-type="bibr" rid="B53">Wei et al., 2018</xref>). <xref ref-type="bibr" rid="B26">K&#x0131;sabay Ak et al. (2022)</xref> investigated risk factors for reduced treatment response in patients with comorbid anxiety and depressive VM, and found that VM patients who do not respond to prophylactic medication should be examined for the presence of comorbid psychiatric disorders and additional treatment strategies should be implemented. <xref ref-type="bibr" rid="B37">Monzani et al. (2006)</xref> found that BPPV patients had significantly higher rates of negative life events, objective negative affect and poor control, anxiety, depression, somatization levels, and obsessive-compulsive attitudes than controls in the year prior to the vertigo episode, suggesting that emotional stress may be a trigger for vestibular dysfunction. A prospective study found that the probability of RD increased with increasing DHI-E scores and that mood disorders may be an important risk factor for RD (<xref ref-type="bibr" rid="B35">Martellucci et al., 2016</xref>). The consensus diagnostic criteria for PPPD formulated by the B&#x00E1;r&#x00E1;ny Society state that anxiety and depression are risk factors for PPPD (<xref ref-type="bibr" rid="B45">Staab et al., 2017</xref>). In this study, we found that patients with comorbid anxiety or depression exhibited more severe vertigo and impacts on somatic symptoms, emotional state, and social function than patients without anxiety and/or depression. Multivariate ordered logistic regression analysis showed that comorbid anxiety or depression was an important risk factor that could significantly exacerbate vertigo. When different types of vestibular syndrome were analyzed separately, the association between EVS and anxiety or depression was most pronounced, with EVS exacerbated by either anxiety or depression. In patients with CVS, anxiety also significantly exacerbated vertigo, consistent with the results of many studies (<xref ref-type="bibr" rid="B38">Morimoto et al., 2019</xref>; <xref ref-type="bibr" rid="B48">Toupet et al., 2019</xref>). Depression had no significant effect on the degree of vertigo in patients with AVS and CVS in the present study, although of course the effect of anxiety and depression on the severity of these two types of vertigo may not be reflected due to the small number of cases of AVS and CVS patients in the study.</p>
<p>Age is one of the principal risk factors for development of both vestibular syndrome and psychological disorders (<xref ref-type="bibr" rid="B34">Maarsingh et al., 2010</xref>). However, there was no significant difference in comorbid anxiety or depression between patients with vertigo of different ages (60 years and older compared with those under 60 years) in the present study. <xref ref-type="bibr" rid="B13">Dietzek et al. (2018)</xref> analyzed 650 patients with chronic vertigo who underwent multimodal vestibular rehabilitation and found that anxiety-related scores were lower in older patients over 65 years of age compared to young and middle-aged adults, and concluded that older adults are affected primarily by physical deficits and anxiety and other psychological factors are less influential. It was previously reported that female patients with vertigo are more likely to experience anxiety and depression than male patients, and that the degree of anxiety and depression in female patients is higher than in male patients. This may be associated with differences in brain structure and function between males and females (<xref ref-type="bibr" rid="B2">Asher and Aderka, 2018</xref>; <xref ref-type="bibr" rid="B33">Lindell et al., 2022</xref>). In the present study, the probability of anxiety and depression did not differ by gender among vertigo patients. This differs from previous studies and may be related to the small sample size of the present study; future studies will focus on large, multi-center samples of vertigo patients.</p>
</sec>
<sec id="S5">
<title>5. Limitation</title>
<p>This study compared the psychological factors of AVS, EVS, and CVS in patients with vestibular syndrome. In the same type of vertigo syndrome, the psychological manifestations of each classified diagnosis disease may differ, especially in EVS. In this study, the statistical analysis among classified diseases was limited due to the small number of cases in a few classified diseases. Also, the psychological status of different diagnosed diseases in the same syndrome was not studied extensively. In future studies, we will conduct more in-depth research and improve on this.</p>
</sec>
<sec id="S6" sec-type="conclusion">
<title>6. Conclusion</title>
<p>In this study, age and gender were not major contributors to a more severe course of vestibular syndromes. Instead, anxiety and depression were found to play a more prominent role. However, the comorbidity of anxiety and depression in patients with vertigo is often overlooked in clinical practice, which exacerbates subjective disability and diminishes patients&#x2019; quality of life. This highlights a crucial insight into managing vertigo: conducting a standardized psychological screening at the outset of treatment can effectively identify patients with comorbid anxiety/depression or other psychological factors, enabling the targeted implementation of psychological interventions. In this regard, scales such as GAD-7/PHQ-9 are valuable tools for rapidly screening patients with vertigo. Also, it is necessary to develop and implement a new screening tool that can assess more accurately the psychological distress experienced by patients with vertigo.</p>
</sec>
<sec id="S7" sec-type="data-availability">
<title>Data availability statement</title>
<p>The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.</p>
</sec>
<sec id="S8" sec-type="ethics-statement">
<title>Ethics statement</title>
<p>The studies involving human participants were reviewed and approved by the Medical Research Ethics Committee of the First Affiliated Hospital of China Medical University. Written informed consent to participate in this study was provided by the participants&#x2019; legal guardian/next of kin.</p>
</sec>
<sec id="S9" sec-type="author-contributions">
<title>Author contributions</title>
<p>SF designed the research. SF and JZ drafted the manuscript. JZ modified the manuscript. Both authors have read and approved to the final version of the manuscript.</p>
</sec>
</body>
<back>
<sec id="S10" sec-type="funding-information">
<title>Funding</title>
<p>This work was supported by the Natural Science Foundation of Liaoning Province of China (No. 2022-MS-03).</p>
</sec>
<sec id="S11" sec-type="COI-statement">
<title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec id="S12" sec-type="disclaimer">
<title>Publisher&#x2019;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
<sec id="S13" sec-type="supplementary-material">
<title>Supplementary material</title>
<p>The Supplementary Material for this article can be found online at: <ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnagi.2023.1208392/full#supplementary-material">https://www.frontiersin.org/articles/10.3389/fnagi.2023.1208392/full#supplementary-material</ext-link></p>
<supplementary-material xlink:href="Table_1.DOCX" id="FS1" mimetype="application/vnd.openxmlformats-officedocument.wordprocessingml.document" xmlns:xlink="http://www.w3.org/1999/xlink"/>
</sec>
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