AUTHOR=Han Xiaowei , Ashraf Muhammad , Tipparaju Srinivas M. , Xuan Wanling 

TITLE=Muscle–Brain crosstalk in cognitive impairment

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 15 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2023.1221653

DOI=10.3389/fnagi.2023.1221653

ISSN=1663-4365

ABSTRACT=Sarcopenia is an age-related involuntary loss of skeletal muscle mass and strength. Alzheimer’s disease (AD) is the most common cause of dementia in the elderly. So far, no effective cures for sarcopenia and AD are    available. Physical and cognitive impairments are two major causes of disability in elderly population, which severely decrease their life quality and increase economic burden. Clinically sarcopenia is strongly associated with AD. However, the underlying factors for this association remain unknown. Mechanistic studies on muscle-brain crosstalk during cognitive impairment might shed light on new insight and novel therapeutic approaches for combating cognitive decline and AD. In this review, we summarize the latest studies emphasizing the association between sarcopenia and cognitive impairment. The underlying mechanisms involved in muscle-brain crosstalk and the potential implications of such crosstalk are discussed. Finally, future directions for drug development to improve age related cognitive impairment and AD related cognitive dysfunction are also explored.