AUTHOR=Bae Heewon , Kang Min Ju , Ha Sang-Won , Jeong Da-Eun , Lee Kiwon , Lim Seungui , Min Jin-Young , Min Kyoung-Bok 

TITLE=Association of plasma amyloid-β oligomerization with theta/beta ratio in older adults

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 15 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2023.1291881

DOI=10.3389/fnagi.2023.1291881

ISSN=1663-4365

ABSTRACT=Background: Oligomeric Aβ (OAβ) is a promising candidate marker for Alzheimer's disease (AD) diagnosis. Electroencephalography (EEG) is a potential tool for early detection of AD. Still, whether EEG power ratios , particularly the theta/alpha ratio (TAR) and theta/beta ratio (TBR), reflect Aβ burden-a primary mechanism underlying cognitive impairment and AD. This study investigated the association of TAR and TBR with amyloid burden in older adults based on MDS-OAβ levels.Methods: 529 individuals (aged ≥60 years) were recruited. All participants underwent EEG (MINDD