AUTHOR=Li Junhong , Ma Cong , Huang Hui , Liao Hui 

TITLE=Amyotrophic lateral sclerosis and osteoporosis: a two-sample Mendelian randomization study

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 15 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2023.1305040

DOI=10.3389/fnagi.2023.1305040

ISSN=1663-4365

ABSTRACT=Background: A few of observational studies revealed that amyotrophic lateral sclerosis (ALS) was tightly connected with osteoporosis. However, results of previous studies were inconsistent and the causal effect of ALS on osteoporosis has not been investigated.To do so, the two-sample mendelian randomization (MR) method was employed to estimate the causality.The instrumental variables (IVs) for ALS were selected from one GWAS summary dataset (27,205 ALS cases and 110,881 controls), bone mineral density (BMD) in femoral neck (FN), lumbar spine (LS) and forearm, extracted from another largescale GWAS summary database (53,236 cases) were used as phenotypes for osteoporosis. Random-effects inverse variance weighted (IVW), MR Egger, weighted median, simple mode, and weighted mode were conducted to evaluate the causality.Sensitivity analyses were further performed to explore the heterogeneity and pleiotropy.Results: 10 qualified SNPs were finally selected as proxies for ALS. The results of random effects IVW showed that ALS has no causal effect on FN-BMD (beta: -0.038,