AUTHOR=Huang Qingqing , Chen Xin , Yu Sixun , Gong Gu , Shu Haifeng 

TITLE=Research progress in brain-targeted nasal drug delivery

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 15 - 2023

YEAR=2024

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2023.1341295

DOI=10.3389/fnagi.2023.1341295

ISSN=1663-4365

ABSTRACT=The unique anatomical and physiological connections between the nasal cavity and brain provide a pathway for bypassing the blood-brain barrier to allow for direct braintargeted drug delivery through nasal administration. There are several advantages of nasal administration compared with other routes; for example, the first-pass effect that leads to the metabolism of orally administered drugs can be bypassed, and the poor compliance associated with injections can be minimized. Nasal administration can also help maximize brain-targeted drug delivery, allowing for high pharmacological