AUTHOR=Tokuda Hisanori , Horikawa Chika , Nishita Yukiko , Kaneda Yoshihisa , Obata Hidenori , Rogi Tomohiro , Izumo Takayuki , Nakai Masaaki , Shimokata Hiroshi , Otsuka Rei 

TITLE=Association between a combination of cognitively stimulating leisure activities and long-chain polyunsaturated fatty acid intake on cognitive decline among community-dwelling older Japanese individuals

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 16 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2024.1406079

DOI=10.3389/fnagi.2024.1406079

ISSN=1663-4365

ABSTRACT=Multifactorial lifestyle approaches could be more effective than a single factor for maintaining cognitive function. This study investigated the association of combining cognitively stimulating leisure activities (CSLA), including puzzles, quizzes, and cognitive training games, with intake of long-chain polyunsaturated fatty acids (LCPUFA), including docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and arachidonic acid (ARA), on cognitive function in the older Japanese individuals without dementia. Participants were community-dwelling Japanese individuals without a self-reported history of dementia (n = 906, aged 60-88 years) from datasets of a 2-year longitudinal study (baseline: 2006-2008 and follow-up: 2008-2010). CSLA engagement and LCPUFA intake were divided into high and low groups according to frequency (≥once/week and