AUTHOR=Zhang Haiyi , Zhang Lu , Lu Juan , Yue Jiajun , Yuan Zhengzhen , Hu Jidan , Yao Qi , Fu Yuting , Chen Guiquan , Fang Jiliang , Zhao Jie 

TITLE=Multiparameter resting-state functional magnetic resonance imaging as an indicator of neuropsychological changes in Binswanger’s disease with mild cognitive impairment

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 17 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2025.1522591

DOI=10.3389/fnagi.2025.1522591

ISSN=1663-4365

ABSTRACT=The underlying neuropathological mechanisms in Binswanger’s disease (BD) with mild cognitive impairment (BD-MCI) remain unclear. The multiparameter functional magnetic resonance imaging (fMRI) including amplitude of low-frequency fluctuations (ALFF), fractional amplitude of low-frequency fluctuations (fALFF), regional homogeneity (ReHo), independent component analysis (ICA), and edge-link analysis was utilized to explore the abnormal brain networks of BD-MCI patients. Compared with the BD without MCI group, this study revealed that the ALFF values in the BD-MCI group were significantly increased in the Temporal_Inf_R, Frontal_Mid_Orb_L, and Hippocampus_L, while decreased in the SupraMarginal_R and Precuneus_R. The fALFF value in the BD-MCI group exhibited a reduction in the Frontal_Med_Orb_L. Additionally, ReHo values in the BD-MCI group increased in the Hippocampus_R but decreased in several areas including Precentral_L, Putamen_L, Postcentral_R, Supp_Motor_Area_R, and SupraMarginal_L. The results of ICA revealed that patients diagnosed with BD-MCI exhibited abnormal connectivity patterns across 12 groups of independent components and 5 distinct groups of brain networks. In one group, the internal connectivity within the brain network exhibited abnormalities. The correlation analysis between ALFF and ReHo values and clinical scales revealed a significant negative correlation between the bilateral hippocampus and Mini-Mental State Examination (MMSE) scores. Conversely, ReHo values for Postcentral_R and SupraMarginal_L were significantly positively correlated with MMSE scores. In summary, the results of our study suggest that patients diagnosed with BD-MCI display atypical activity across several brain regions. The observed changes in these areas encompass a range of functional networks. The reduced coordination among these functional networks may play a role in the deterioration of cognitive functions and decision-making capabilities, potentially serving as a critical mechanism contributing to the early manifestation of cognitive impairments.