AUTHOR=Zheng Jiaqian , Mao Weiwen , Sang Mengqian , Pan Xinyu , Xie Yiluo , Xie Yichi 

TITLE=Triglyceride-glucose indices predict all-cause mortality after stroke in NHANES 1999–2018

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 17 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2025.1617419

DOI=10.3389/fnagi.2025.1617419

ISSN=1663-4365

ABSTRACT=ObjectiveThe present study explores the prognostic relevance of triglyceride-glucose–based indices in assessing post-stroke survival among affected individuals.MethodsThis study utilized a multifaceted analytical approach to assess how triglyceride-glucose–based indicators relate to death risk in stroke patients. This study was analyzed using a multivariate Cox proportional risk regression model incorporating sampling weights, while a restricted cubic spline function was introduced to assess trends in non-linear associations between exposure variables and outcomes. In addition, interaction terms were set and stratified analyses were conducted to verify the robustness and heterogeneity of the model results.ResultsThis research ultimately included 796 individuals diagnosed with stroke. When adjusting for a wide range of potential confounders, those in the top TyG-BMI quartile exhibited the most pronounced reduction in mortality risk compared to individuals in the lowest category, with a hazard ratio of 0.20 (95% CI: 0.08–0.50), highlighting its protective potential across TyG-BMI. In contrast, individuals falling within the fourth quartile of the TyG-WHtR index demonstrated the strongest positive correlation with the risk of all-cause mortality (Hazard Ratio = 4.61, 95% CI: 1.77–12.00). Moreover, analysis using restricted cubic splines indicated a significant non-linear association between TyG-BMI levels and mortality outcomes (p < 0.05). No statistical interactions were observed between mortality outcomes and demographic or clinical variables including age, sex, smoking, asthma, coronary artery disease, diabetes, or hypertension across any TyG-related indices (p > 0.05).ConclusionThe study outcomes suggest that stroke patients with reduced TyG-BMI and elevated TyG-WHtR levels tend to face increased mortality risks. Nonetheless, addressing obesity may be crucial in exploring potential causal pathways.