AUTHOR=Gogniat Marissa A. , Won Junyeon , Cruz Carlos , Aranda Amaya , Verma Aryan , Gujral Swathi , Weinstein Andrea M. , Zaheed Afsara B. , Cole Keith R. , Full Kelsie M. , Snitz Beth E. 

TITLE=Sedentary behavior, cognition, and brain health in older adults: a systematic review

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 17 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2025.1622049

DOI=10.3389/fnagi.2025.1622049

ISSN=1663-4365

ABSTRACT=Sedentary behavior has been associated with poor health outcomes, especially in older adulthood. Given that sedentary behavior is a highly prevalent, modifiable health behavior, there has been a recent increased interest in examining how sedentary behavior relates to cognition and brain health. The current body of literature is limited and mixed. The purpose of this systematic review was to examine the associations of sedentary behavior with cognition and brain health in older adults across the cognitive spectrum. This study was pre-registered with PROSPERO (CRD42023477868). Six comprehensive databases were searched with pre-registered search terms. A total of 33 studies were included. Overall, results indicated that greater sedentary behavior was associated with worse cognition and brain health, although associations varied based on differences in measurement and classification of sedentary behavior. We discuss next steps and implications for future research.