AUTHOR=Myers Tyler , Bouslimani Amina , Huang Shi , Hansen Shalisa T. , Clavaud Cécile , Azouaoui Anissa , Ott Alban , Gueniche Audrey , Bouez Charbel , Zheng Qian , Aguilar Luc , Knight Rob , Moreau Magali , Song Se Jin 

TITLE=A multi-study analysis enables identification of potential microbial features associated with skin aging signs

JOURNAL=Frontiers in Aging

VOLUME=Volume 4 - 2023

YEAR=2024

URL=https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2023.1304705

DOI=10.3389/fragi.2023.1304705

ISSN=2673-6217

ABSTRACT=We confirm the positive link between chronological age and skin microbiome diversity, but we also observed a global positive association between microbiome diversity and grade of Crow's feet wrinkles, one of the key signs of skin aging, although the relationship varied among the included sub-studies. We additionally observed a negative link between microbiome diversity and transepidermal water loss.• The link between Crow's feet wrinkles and microbial features were explored while considering the effect of individual studies and chronological age as a confounder, identifying several potential biomarkers.• Building a multi-study analysis using independent studies is a valuable method to bolster sample sizes and address questions not possible by individual studies alone. However, as the sub-studies are often generated by different principal investigators and methods, analysis relies on data harmonization and the use of analytic tools that are able to account for those differences.