AUTHOR=Altintas Ozlem , MacArthur Michael R. 

TITLE=General control nonderepressible 2 (GCN2) as a therapeutic target in age-related diseases

JOURNAL=Frontiers in Aging

VOLUME=Volume 5 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2024.1447370

DOI=10.3389/fragi.2024.1447370

ISSN=2673-6217

ABSTRACT=The function of General Control Nonderepressible 2 (GCN2), an evolutionary-conserved component of the integrated stress response (ISR), has been well-documented across organisms from yeast to mammals. Recently GCN2 has also gained attention for its role in health and disease states. In this review, we provide a brief overview of GCN2, including its structure, activation mechanisms and interacting partners, and explore its potential significance as a therapeutic target in various age-related diseases including neurodegeneration, inflammatory disorders and cancer. Finally, we summarize the barriers to effectively targeting GCN2 for the treatment of disease and to promote a healthier aging process.