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        <title>Frontiers in Aging | New and Recent Articles</title>
        <link>https://www.frontiersin.org/journals/aging</link>
        <description>RSS Feed for Frontiers in Aging | New and Recent Articles</description>
        <language>en-us</language>
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        <pubDate>2026-09-25T10:03:23.917+00:00</pubDate>
        <ttl>60</ttl>
        <item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1792585</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1792585</link>
        <title><![CDATA[Ultrasonographic evaluation of quadriceps femoris muscle mass in critically ill patients aged 60 years and older: a prospective observational study]]></title>
        <pubdate>2026-09-24T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Nestor-Julian Zarate-Herran</author><author>Johan-Sebastián Villada-Gómez</author><author>Nestor-David Caicedo</author><author>Diana-María Trejos-Gallego</author><author>Fernando Gomez</author>
        <description><![CDATA[Background and aimsMuscle wasting is a common complication in critically ill older adults admitted to intensive care units (ICU), with significant implications for morbidity and mortality. Ultrasound represents a promising bedside tool for assessing muscle mass changes. This study aimed to evaluate changes in quadriceps femoris muscle mass using ultrasonography at ICU admission and after 7 days of stay in patients aged 60 years and older.MethodsA prospective cohort study with repeated measurements was conducted between December 2024 and May 2025. Patients aged ≥60 years admitted to the ICU were included. Ultrasonographic measurements included rectus femoris cross-sectional area (RFCSA), bilateral quadriceps muscle thickness, and rectus femoris pennation angle at admission and day 7. Clinical characteristics, severity scores (APACHE II, SOFA), and functional status (Barthel index) were recorded. Statistical analysis included Wilcoxon signed-rank test and robust statistics.ResultsFifty patients were analyzed (60% male, median age 72.5 years). Significant muscle mass reductions were observed: RFCSA decreased by 16.2% (2.525–2.115 cm2, p < 0.001), right quadriceps thickness by 14.6% (2.012–1.719 cm, p < 0.001), left quadriceps thickness by 20.2% (2.049–1.635 cm, p < 0.001), and pennation angle by 18.2% (7.664°–6.270°, p < 0.001). ICU mortality was 30%. Multivariate analysis identified advanced age, female sex, hypoglycemic agent use, higher SOFA scores, and lower premorbid Barthel index as factors associated with greater muscle loss.ConclusionCritically ill older adults experience significant quadriceps muscle mass loss within the first week of ICU stay, as measured by bedside ultrasonography. These findings support the implementation of early muscle assessment and targeted interventions in this vulnerable population.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1987600</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1987600</link>
        <title><![CDATA[Editorial: Biomarkers and aging: new insights for precision medicine]]></title>
        <pubdate>2026-09-21T00:00:00Z</pubdate>
        <category>Editorial</category>
        <author>Oluwafemi Gabriel Oluwole</author><author>Paulo Adriano Schwingel</author>
        <description></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1992402</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1992402</link>
        <title><![CDATA[Correction: Cognitive and behavioral benefits of newspaper reading in community‐dwelling older adults: a feasibility randomized controlled trial]]></title>
        <pubdate>2026-09-21T00:00:00Z</pubdate>
        <category>Correction</category>
        <author>Mamoru Sato</author><author>Sawako Negoto</author><author>Shinya Nakano</author><author>Chihoko Urata</author><author>Tetsuya Ioji</author><author>Hideya Kodama</author><author>Emi Yoshimura</author><author>Yukinori Tasaki</author><author>Shinichiro Goroku</author><author>Kiichiro Morita</author><author>Yoshihisa Shoji</author>
        <description></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1858090</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1858090</link>
        <title><![CDATA[CaroRite™ for improving skin health and the visible signs of aging - a randomised, double-blind, placebo-controlled trial]]></title>
        <pubdate>2026-09-21T00:00:00Z</pubdate>
        <category>Clinical Trial</category>
        <author>Amanda Rao</author><author>Janice Pellow</author><author>David Briskey</author>
        <description><![CDATA[BackgroundThere is an increasing need to identify novel ingredients that can be safely utilized to enhance skin function and mitigate skin aging. Carotenoid supplementation shows promise in improving skin health and reducing signs of aging, owing to its antioxidant and anti-inflammatory properties.AimThis randomised, double-blind, placebo-controlled study aimed to investigate the efficacy of a carotenoid supplement, CaroRite™, on skin health and the visible signs of aging in healthy females.MethodsEighty female participants aged 40–55 years were recruited and randomised to receive either CaroRite™ (containing 28–30 mg mixed carotenoids) or a placebo. Participants were instructed to take one capsule daily for 12 weeks. Outcome measures included visible signs of aging (wrinkles, skin elasticity, hydration, sebum, pigmentation, pore size, and temperature), transepidermal water loss (TEWL), dermal thickness, skin carotenoid levels, dietary carotenoid intake, and safety.ResultsNo significant between-group differences were observed for visible signs of aging parameters (p > 0.05). At week 12, significant between-group differences from baseline were observed for TEWL (CaroRite™ −4.58 ± 9.43 vs. placebo 0.34 ± 6.73; p = 0.011) and dermal thickness (CaroRite™ 139.50 ± 220.21 μm vs. placebo 43.90 ± 225.97 μm; p = 0.036). Skin carotenoid levels increased by 48.1% in the active group (CaroRite™ +167.09 ± 117.23 vs. placebo 9.42 ± 47.16; p < 0.001), despite no significant differences in dietary carotenoid intake between groups.ConclusionDaily oral supplementation with CaroRite™ did not reduce the visible signs of ageing after 12 weeks, however notable improvements in skin carotenoid status, TEWL and dermal thickness was found. CaroRite™ demonstrated good bioavailability and was well tolerated. Overall, these findings support the use of CaroRite™ as part of a comprehensive approach to potentially improving skin health, particularly for enhancing skin carotenoid status and supporting underlying structural and barrier function.Clinical Trial RegistrationClinicalTrials.gov, Identifier NCT06878001.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1866906</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1866906</link>
        <title><![CDATA[Unraveling skeletal muscle senescence in an in vitro cell culture model]]></title>
        <pubdate>2026-09-18T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Kayo Moreira Bagri</author><author>Morgana Teixeira Lima Castelo-Branco</author><author>Claudia Mermelstein</author>
        <description><![CDATA[IntroductionSkeletal muscles are crucial for voluntary movement, posture, breathing, joint stability, and therefore are essential for maintaining overall health and quality of life. Aging, sarcopenia, cancer, immobilization, and several muscle pathologies can have an impact on muscle function, and muscle cell senescence is associated with these conditions.MethodsHere we aimed to develop a primary cell culture model to study skeletal muscle cell senescence. We induced cell cycle arrest in cultured embryonic chick muscle cells using a low concentration of cytosine arabinoside (Ara-C) for 9 days.ResultsOur results show that Ara-C was able to induce several cellular senescence-associated bone fide characteristics, including reduced cell proliferation, increased β-galactosidase expression, increased reactive oxygen species production (ROS), increased p53 and p21 expression, increased muscle fibroblast cell size and nuclei numbers, increased lysosomal activity, decreased muscle differentiation (decreased muscle fiber size and decreased desmin expression), and increased secretion of IL-6, TNFα and TGFβ. Interestingly, inhibition of fibroblast growth factor receptor recovers the AraC-induced senescent phenotype in myogenic cells.ConclusionThis new experimental model could be used to deepen our understanding of the molecules and signaling pathways associated with the initiation and establishment of skeletal muscle senescence. Furthermore, this model could be used to test new drugs and therapeutic interventions aiming the amelioration of senescence-associated conditions.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1870256</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1870256</link>
        <title><![CDATA[Association of smoking cessation with late-life frailty risk: the Singapore Chinese health study]]></title>
        <pubdate>2026-09-17T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Ainsley Ryan Yan Bin Lee</author><author>Huiqi Li</author><author>Kevin Yiqiang Chua</author><author>Woon-Puay Koh</author>
        <description><![CDATA[ObjectiveTo examine whether smoking cessation, in terms of duration and age at quitting, was associated with late-life physical frailty.DesignProspective population-based cohort study.SettingChinese living in Singapore.ParticipantsWe analyzed data from 4,574 men (mean baseline age 52.7 years, range 45–65 years) enrolled in the Singapore Chinese Health Study.MeasurementsParticipants self-reported smoking behaviors at four time-points over a 20-year follow-up. Physical frailty was assessed in late life (mean age 73.6 years, range 65–88 years) using a modified Cardiovascular Health Study phenotype, incorporating weakness, slowness, exhaustion and weight loss. Multivariable logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for association with frailty.ResultsPersistent smokers had higher odds of frailty compared to never smokers (OR: 1.34; 95% CI: 1.01–1.76). Those who had quit smoking within 10 years before frailty assessment also had increased odds (OR = 1.33; 95% CI: 0.86–2.01), albeit not statistically significant. The OR (95% CI) was attenuated to 1.08 (0.76–1.51) for those quitting 10–20 years and 0.97 (0.59–1.55) for those quitting >40 years. Those who quit smoking by age 60 years had similar odds relative to never smokers: OR was 1.05 (0.74–1.48) for quitting at ages 50–60 years and further reduced to 0.86 (0.57–1.25) for quitting at ages <40 years.ConclusionWhile persistent smoking was associated with increased odds of late-life physical frailty, smoking cessation for at least 10 years, or before the age of 60 years, could mitigate this risk substantially.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1920709</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1920709</link>
        <title><![CDATA[Role of essential and trace elements in chronic myeloid leukemia: associations with serum trace element profiles and hematological parameters]]></title>
        <pubdate>2026-09-14T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Ajay Kumar Yadav</author><author>Umesh Choudhary</author><author>Anupam Aich</author><author>Lalit Prashant Meena</author><author>Royana Singh</author><author>Shivam Tiwari</author><author>Ashish Ashish</author>
        <description><![CDATA[BackgroundChronic myeloid leukemia is a myeloproliferative malignancy characterized by the Philadelphia chromosome with uncontrolled expansion of myeloid cells. Trace elements are essential for cellular metabolism, DNA repair, antioxidant defence, and immune regulation, and their imbalance may influence leukemogenesis and contribute to oxidative stress, immune dysregulation, and hematological alterations. Profiling trace elements may improve understanding of CML-associated trace element alterations and identify candidate biomarkers for future validation.Material and methodsA cross-sectional study at Banaras Hindu University, India, included 93 CML patients and 93 age and sex-matched healthy controls from an eastern Indian population. Serum chromium (Cr), copper (Cu), manganese (Mn), lead (Pb), cadmium (Cd), arsenic (As), iron (Fe), selenium (Se), and zinc (Zn) concentrations were measured by atomic absorption spectroscopy. Complete blood counts were performed, and data analysed using descriptive statistics, Mann–Whitney U test, Chi-square/Fisher’s exact tests, and Spearman correlation analysis.ResultsCML patients exhibited significantly elevated serum concentrations of Cu, Mn, Pb, Cd, and As compared with healthy controls, whereas Cr, Fe, Se, and Zn concentrations were significantly higher in healthy controls. Several trace elements showed statistically significant associations with hematological parameters, suggesting complex interactions between elemental imbalance and CML biology.ConclusionThis study strongly shows dysregulation of essential and toxic trace elements in CML. Imbalance of selenium (Se), zinc (Zn), iron (Fe), manganese (Mn), and copper (Cu) may contribute to oxidative stress, immune dysfunction, and leukemogenesis, and toxic metals may enhance genomic instability. Trace-element profiling, especially selenium-related biomarkers, may serve as candidate biomarkers associated with CML and warrant validation in larger prospective studies.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1869084</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1869084</link>
        <title><![CDATA[Sex-specific effects of automated feeding on lifespan and reproduction in Nothobranchius furzeri]]></title>
        <pubdate>2026-09-14T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Luca Dolfi</author><author>Michael Kothmayer</author><author>Elmar Erwin Ebner</author><author>Renate Löhnert</author><author>Oliver Pusch</author>
        <description><![CDATA[IntroductionNothobranchius furzeri, commonly known as African turquoise killifish, has emerged as a powerful model organism in diverse biological research areas owing to its exceptionally short lifespan of 4‐6 months. Dietary choices can significantly impact the physiology of this fish and its median longevity, prompting considerations on live versus dry food and feeding frequencies.MethodsHere, we present a novel, cost‐effective, and modular automated feeding system for N. furzeri, capable of delivering up to 36 feedings per day with high precision. Using this system, we conducted a comprehensive, multi‐parametric analysis comparing the effects of three commercially available dry diets varying in protein and fat content and live chironomid larvae (bloodworms), administered either via high‐frequency automated feeding or manual twice‐daily feeding.ResultsA continuous diet of 24‐36 feedings per day increased fish growth in weight but not in length compared to a standard twice‐daily regimen. Unexpectedly, while male lifespan remained unaffected by feeding regimen or diet, females subjected to high‐frequency automated feeding showed reduced longevity, particularly with high‐calorie diets. Additionally, pooled reproductive profiles suggested that reproductive output was associated with dietary fat and protein content as well as feeding frequency. Greater delivered food availability, particularly under high‐frequency feeding with energy‐rich diets, was associated with increased egg production, reduced embryo survival, and a shortened reproductive period.DiscussionTogether, these findings provide important insights for optimizing husbandry and experimental design in N. furzeri, supporting its broader application as a high‐throughput vertebrate model.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1923046</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1923046</link>
        <title><![CDATA[Explanatory limitations of CSF, plasma, and MRI biomarkers for inflammation and blood–brain barrier disruption in dementia]]></title>
        <pubdate>2026-09-11T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Azadeh Golduzian</author><author>Erik B. Erhardt</author><author>Arvind Caprihan</author><author>John C. Adair</author><author>Janice E. Knoefel</author><author>Jill Prestopnik</author><author>Sasha Hobson</author><author>Sephira Ryman</author><author>Andrei Vakhtin</author><author>Kiran Bhaskar</author><author>Gary A. Rosenberg</author>
        <description><![CDATA[Inflammation and blood–brain barrier (BBB) disruption are increasingly implicated in cognitive decline, but it remains unclear which fluid and imaging measures best capture these processes. Participants were drawn from two overlapping research programs, MarkVCID and UNM ADRC. We studied 149 participants with Alzheimer’s disease, leukoaraiosis, mixed dementia, subcortical ischemic vascular dementia, or memory impairment. BBB permeability was assessed using the albumin index (Qalb), a global blood-to-CSF leakage ratio, and dynamic contrast-enhanced MRI permeability (Ktrans), a regional gadolinium transfer measure. Both were treated as permeability measures that inflammation may influence rather than as direct measures of inflammation. CSF and plasma biomarkers included matrix metalloproteinases, angiogenic factors, cytokines, GFAP, NfL, pTau181, and Aβ42/40; MRI measures included PSMD, mean free water, hippocampal volume, and cortical thickness. Univariate associations were screened using Spearman correlation and AIC, and multivariable models used AIC-based stepwise selection. Diagnosis-adjusted models, bootstrap selection frequencies, penalized regression, and cross-validated R2 were used as sensitivity analyses. Qalb and Ktrans were not significantly correlated (Spearman ρ = 0.14, p = 0.28), suggesting that they index different dimensions of BBB dysfunction without establishing biological independence. The multivariable CSF model for Qalb retained MMP-2, Flt-1, IL-8, GFAP, and NfL and explained approximately half the variance (R2 = 0.53), whereas the plasma model explained less variance (R2 = 0.32). For Ktrans, multivariable CSF, plasma, and MRI models explained R2 = 0.36, 0.39, and 0.14, respectively, while PSMD was the strongest FDR-robust univariate MRI correlate. CSF–plasma correlations ranged from near zero for MMP-9 (r = −0.03) to stronger associations for NfL (r = 0.74) and IL-13 (r = 0.70), indicating that plasma cannot be assumed to substitute for CSF marker-by-marker. Qalb and Ktrans should be considered complementary rather than interchangeable measures. The Qalb–CSF model showed the strongest inflammation-related signal, but these findings are exploratory and require validation in independent, longitudinal cohorts before an inflammation axis can be incorporated into an ATN(V)-based framework.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1876169</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1876169</link>
        <title><![CDATA[Rumo zhentong Yin for blood-stasis-type osteoporotic pain: protocol of a randomized, single-blind, controlled trial]]></title>
        <pubdate>2026-09-11T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Qian Zhang</author><author>Yuanjie Song</author><author>Bailu Niu</author><author>Mianjie Liang</author><author>Jingjing Yang</author><author>Yanjie Tong</author><author>Hui Wang</author>
        <description><![CDATA[BackgroundOsteoporosis (OP) is a metabolic skeletal disease characterized by reduced bone mass and micro-architectural deterioration, with Osteoporotic pain (OPP) as its most common clinical symptom, which markedly impairs quality of life. Modern pharmacologic treatments’ limitations are obvious with population aging, so the cost-effective interventions for OPP are urgently needed. As an empirical formula, Rumo zhentong Yin has been created by the national renowned veteran Traditional Chinese Medicine (TCM) practitioner Yao Shujin for blood-stasis pain. Hence, this trial was designed to investigate the efficacy of Rumo zhentong Yin in treating blood-stasis-type OPP.MethodsA randomized, single-blind, controlled trial was designed to evaluate the efficacy of Rumo zhentong Yin combined with standard therapy for OPP. Eligible OPP patients were recruited and randomly assigned (1:1) to form either the control or treatment group. Both groups received standard treatment. The intervention lasted 3 months, with follow-up evaluations every 4 weeks. Primary outcome was pain scores; secondary outcomes included bone mineral density (BMD), bone-turnover markers, inflammatory cytokines, blood-stasis syndrome score and hematological indices.Anticipated ResultsTo our knowledge, this trial is the first clinical study of Rumo zhentong Yin for OPP, with the primary objective to provide robust clinical evidence supporting the integration of Traditional Chinese and Western medicine for OPP.Trial RegistrationThe trial was registered at the International Traditional Medicine Clinical Trial Registry (www.itmctr.ccebtcm.org.cn) on 2026-01-08 (ITMCTR2026000740).]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1887175</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1887175</link>
        <title><![CDATA[Narrative review of intravenous NAD+ and NAD+ precursors in wellness and translational medicine]]></title>
        <pubdate>2026-09-10T00:00:00Z</pubdate>
        <category>Review</category>
        <author>Abdulrahman Alangari</author><author>Jamal Arif</author><author>Fahd Al Qureshah</author><author>Fahad Alkhodairy</author>
        <description><![CDATA[BackgroundNicotinamide adenine dinucleotide (NAD+) is a major coenzyme critically involved in cellular metabolism, mitochondrial function, DNA repair, and stress-response signaling. Age-associated decline in NAD+ levels has generated interest in NAD+-augmenting strategies; however, recent large-scale human data indicate that whole-blood NAD+ concentrations do not decline with healthy aging per se. Despite increasing commercial use of IV NAD+ therapy in wellness settings, the clinical evidence supporting its efficacy and long-term safety remains limited.MethodsLiterature published between January 2018 and March 2026 was identified via PubMed and Google Scholar searches. Search terms were applied symmetrically across all target compounds and administration routes. Studies were included if they reported human clinical data on IV NAD+ or IV NAD+ precursor administration, or if they provided directly relevant mechanistic or safety evidence. Mechanistic and foundational studies published before 2018 were selectively incorporated via citation tracking of key included articles.ResultsAvailable human evidence is sparse and consists primarily of small uncontrolled studies, observational investigations, and isolated case reports. Short-term IV NAD+ or NMN administration has been associated with transient increases in circulating NAD+ levels and changes in selected biomarkers related to oxidative stress, inflammation, and cellular metabolism. Limited exploratory reports have also described self-reported improvements in sleep-related outcomes and neurologic symptoms. However, the clinical significance of these findings remains uncertain due to small sample sizes, lack of placebo controls, heterogeneous methodologies, and short follow-up durations. Reported adverse effects include nausea, cramping, flushing, and chest discomfort, while long-term safety data are lacking.ConclusionCurrent evidence regarding IV NAD+ therapy remains preliminary and insufficient to support routine clinical or wellness use. Although mechanistic and translational studies provide biological rationale for NAD+ augmentation, robust conclusions regarding efficacy, durability of benefit, optimal dosing, and long-term safety cannot currently be established. Larger randomized controlled trials with standardized protocols and clinically meaningful endpoints are required before IV NAD+ therapy can be considered evidence-based clinical practice.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1809697</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1809697</link>
        <title><![CDATA[Structured lifestyle modification and biological aging: effects on PhenoAge, sclerostin, and GDF-15 in arab adults with prediabetes]]></title>
        <pubdate>2026-09-10T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Ahmed Alenezi</author><author>Shaun Sabico</author><author>Abdullah M. Alnaami</author><author>Syed D. Hussain</author><author>Mohamed S. Elrobh</author><author>Nasser M. Al-Daghri</author>
        <description><![CDATA[BackgroundLifestyle modification programs (LMP) such as diabetes prevention programs may influence phenotypic aging trajectories, but evidence in Middle Eastern populations remains limited. This study examined the effects of a structured LMP on phenotypic age (PhenoAge) as the primary endpoint and circulating sclerostin (SOST) and growth differentiation factor-15 (GDF-15) as secondary endpoints in a cohort of Arab adults with prediabetes.Participants and MethodsIn this randomized clinical trial (RCT), a total of 181 adults (130 males, 51 females; mean age 50.8 ± 10.9 years, body mass index, BMI 30.0 ± 4.8 kg/m2) were enrolled. Participants were allocated to either a structured LMP or Control Group (CG) and followed for 6 months. The LMP group was requested to reduce weight by 5%, moderate exercise (150 min/week), reduce fat intake (30%) and increase fiber intake (15g/1 kcal). CG was given brochure. PhenoAge was calculated and assessed alongside anthropometrics, blood biomarkers (HbA1c, fasting glucose, albumin, creatinine, GDF15, SOST), and dietary parameters at baseline and after 6 months.ResultsCompared with the CG, participants in the lifestyle modification program (LMP) showed a significant reduction in PhenoAge (−4.9 vs. +1.3 years; between-group p < 0.001). Significant between-group improvements were also observed in weight (−5.7 kg), BMI (−2.0 kg/m2), waist circumference (−6.3 cm), and HbA1c (−0.4%; all p < 0.001). Neither GDF-15 nor SOST demonstrated a significant intervention-specific effect.ConclusionA structured lifestyle intervention significantly improved PhenoAge, accompanied by improvements in metabolic parameters in Arab adults with prediabetes. Changes in GDF-15 and SOST appeared time-dependent rather than intervention-specific. These findings support lifestyle modification as a potential strategy to slow a composite clinical measure of biological aging. ClinicalTrial Registration (NCT06440681).]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1682867</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1682867</link>
        <title><![CDATA[Molecular markers, mechanisms and metrics of biological aging: a scoping review]]></title>
        <pubdate>2026-09-08T00:00:00Z</pubdate>
        <category>Review</category>
        <author>Alison Ziesel</author><author>Jennifer Reeves</author><author>Anastasia Mallidou</author><author>Lorelei Newton</author><author>Ryan E. Rhodes</author><author>Jie Zhang</author><author>Theone Paterson</author><author>Hosna Jabbari</author>
        <description><![CDATA[Biological aging is a rapidly growing area of research, which entails characterizing the rate of aging independent of an individual’s chronological age. In this scoping review, we analyze the results of biological aging research in 435 papers published in a 12 year window spanning 2011 through June 2023, 309 of which focus on non-methylation-based biomarkers, revealing changing patterns of molecular markers of biological aging use over time as well as the development of novel metrics of biological aging. We further identify consistent and discordant research findings, as well as areas of potential future research focusing on questions of measurement with biomarker-based assessment and other variables relevant to the study of biological age.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1915136</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1915136</link>
        <title><![CDATA[Effects of mind-body exercise on balance function in pre-frail and frail older adults: a systematic review and meta-analysis]]></title>
        <pubdate>2026-09-08T00:00:00Z</pubdate>
        <category>Systematic Review</category>
        <author>Wangyouyi Chen</author><author>Yiwen Bai</author><author>Liuling Song</author>
        <description><![CDATA[BackgroundFrailty and pre-frailty are common geriatric conditions associated with reduced physiological reserve and a higher risk of falls. Mind–body exercises such as Tai Chi, Baduanjin, and Yoga are widely recommended as low-intensity interventions, while their specific effects on different aspects of balance remain unclear.ObjectiveThis systematic review and meta-analysis aimed to evaluate the effects of mind–body exercise on overall, dynamic, and static balance in pre-frail and frail older adults and to examine whether frailty stage and exercise characteristics influence outcomes.MethodsOur literature search was conducted in PubMed, Web of Science, Cochrane Library, Embase, CNKI, Wanfang Data, and VIP Databases up to March 2026. Randomized controlled trials comparing mind–body exercise with usual care, health education, or no intervention in pre-frail or frail older adults were included. Pooled effect sizes were calculated as standardized mean differences (SMDs) with 95% confidence intervals (CIs) using random-effects models. Prespecified subgroup analyses were performed according to frailty stage, exercise frequency, session duration, and intervention length.ResultsTen RCTs with 12 comparisons were included. Mind–body exercise showed significant improvements in overall balance (SMD = 0.54, 95% CI 0.17–0.91), dynamic balance (SMD = −1.08, 95% CI −1.41 to −0.76), and static balance (SMD = 1.36, 95% CI 0.43–2.30). Exploratory subgroup analyses suggested that interventions delivered 2–4 times weekly, lasting 31–60 min per session, and continuing for at least 13 weeks were associated with relatively more consistent effects; however, these findings should be interpreted cautiously because they were derived from indirect subgroup comparisons rather than formal dose–response analyses.ConclusionMind–body exercise appears to be an effective and practical strategy for improving balance in pre-frail and frail older adults, particularly when implemented early in the frailty trajectory.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1931190</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1931190</link>
        <title><![CDATA[Gender differences in the association between marriage and epigenetic age]]></title>
        <pubdate>2026-09-07T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Theo O. Moran</author><author>Alina M. Kushner</author><author>Theodore F. Robles</author><author>Jennifer W. Robinette</author>
        <description><![CDATA[IntroductionBeing married is related to better health, but many studies reveal greater health benefits among men relative to women. Some research has indicated that married individuals exhibit decelerated epigenetic age relative to individuals who are not married, but questions remain regarding gender differences therein. The purpose was to investigate gender differences in associations of marital status to epigenetic age (ing) assessed on three clocks/algorithms (PhenoAge, GrimAge, and DunedinPACE).MethodsData from 762 participants in the national Midlife in the United States Study (MIDUS II; men N = 382, women N = 380) were used. Weighted linear regressions were conducted to test the hypotheses that 1) being married would be associated with decelerated epigenetic age (ing) and that 2) this association would be stronger among men than women.ResultsBeing married, relative to being separated or divorced, was associated with decelerated epigenetic aging on DunedinPACE, although not PhenoAge or GrimAge. Investigating gender differences revealed a divergence regarding never marrying, a marital status that accelerated GrimAge and DunedinPACE scores among men, but not women.DiscussionThese results contribute new knowledge about marital status and early risk for disease, as indicated by accelerated pace of aging among men and women whose relationships dissolved. More research is needed to identify factors explaining why men who never marry may be at risk for accelerated epigenetic aging while women are not.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1835897</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1835897</link>
        <title><![CDATA[Association between preoperative cognitive impairment and perioperative neurocognitive disorders within 30 days after surgery in elderly patients: a secondary exploratory retrospective analysis]]></title>
        <pubdate>2026-09-07T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Keke Song</author><author>Ping He</author><author>Xiaoqi Zhao</author><author>Rongsheng Zhou</author><author>Yaomin Zhu</author><author>Xiaofei Liu</author><author>Xin Zhang</author>
        <description><![CDATA[BackgroundPreoperative cognitive impairment (PCI) is a recognized risk factor for postoperative cognitive dysfunction, but its association with the broader syndrome of perioperative neurocognitive disorders (PND) within 30 days after surgery requires further investigation. This study aimed to evaluate the association between preoperative cognitive performance, assessed by the Montreal Cognitive Assessment (MoCA), and the risk of PND in elderly patients.MethodsThis secondary exploratory retrospective analysis based on a completed prospective randomized controlled trial (RCT) cohort included 236 patients aged ≥65 years undergoing non-cardiac surgery under general anesthesia. Preoperative cognitive performance was evaluated using the MoCA, with a score <26 defining PCI. PND was defined as either postoperative delirium (assessed daily with CAM-ICU) or delayed neurocognitive recovery (assessed by MoCA at 7 and 30 days postoperatively). Logistic regression models were used to analyze the association between PCI (as a binary and continuous variable) and PND, adjusting for confounders including age, education, frailty, and surgical factors.ResultsThe overall incidence of PND was 40.7%. Patients with PCI (n = 81) had a significantly higher incidence of PND compared to those without PCI (74.1% vs. 23.2%, p < 0.001). In unadjusted analysis, PCI was associated with a 9.44-fold increased odds of PND (OR = 9.44, 95% CI: 5.07–17.58). After multivariable adjustment, PCI remained independently associated with PND (adjusted OR = 6.95, 95% CI: 2.71∼17.79). When analyzed as a continuous variable, each 1-point increase in the MoCA score was associated with a 32% reduction in the odds of PND (adjusted OR = 0.68, 95% CI: 0.58∼0.80). Subgroup analyses showed no statistically significant interaction was observed with age, education, or frailty.ConclusionPreoperative cognitive impairment, assessed by the MoCA, is an independent risk factor for PND within 30 days after surgery in elderly patients. Preoperative MoCA screening may help identify high-risk patients for targeted interventions.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1929793</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1929793</link>
        <title><![CDATA[Cognitive and behavioral benefits of newspaper reading in community-dwelling older adults: a feasibility randomized controlled trial]]></title>
        <pubdate>2026-09-04T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Mamoru Sato</author><author>Sawako Negoto</author><author>Shinya Nakano</author><author>Chihoko Urata</author><author>Tetsuya Ioji</author><author>Hideya Kodama</author><author>Emi Yoshimura</author><author>Yukinori Tasaki</author><author>Shinichiro Goroku</author><author>Kiichiro Morita</author><author>Yoshihisa Shoji</author>
        <description><![CDATA[IntroductionThere are reports suggesting that reading newspapers is an accessible daily intellectual activity that may help prevent neurocognitive disorders, while no prospective studies have accurately investigated its effectiveness on cognitive function.MethodsThis study is a randomized controlled trial designed to explore the effects of reading newspapers on cognitive function and activity levels in community-dwelling older adults. The study included 163 non-subscribers aged 60 years or older; after screening, 64 participants were selected. Participants were randomly assigned to either the newspaper reading group (n = 31) or the non-reading group (n = 32), and a 26-week randomized controlled trial (RCT) was conducted. One person was disqualified because they could not be contacted. The newspaper reading group was instructed to read the newspaper at least four days a week, and compliance was verified by checking entries on activity log sheets. In addition, both groups were assessed before and after the trial. The primary outcome was cognitive function assessed using the Japanese Version of the MONTREAL COGNITIVE ASSESSMENT (MoCA-J). Secondary outcomes included the Mini Mental State Examination (MMSE-J), the Japanese version of the Geriatric Depression Scale-15 (GDS-15-J), the Life-Space Assessment (LSA), and the Vitality Index.ResultsWhen comparing the changes in these test items after 26 weeks, the newspaper reading group showed significantly better results than the non-reading group for the MoCA-J (difference: 1.47 [95% CI: 0.31–2.63], p = 0.013), GDS-15-J (difference: –1.85 [95% CI: –3.01 to –0.68], p = 0.002), and LSA (difference: 14.74 [95% CI: 7.13–22.35], p < 0.001). A significant trend was also observed in the newspaper reading group for the MMSE-J (difference: 2.46 [95% CI: 1.34–3.58], p = 0.065).DiscussionThese findings suggest that reading newspapers is a low-cost, self-directed intervention that can be easily incorporated into preventive care for community-dwelling older adults and may have beneficial effects on cognitive function and activity levels.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1902964</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1902964</link>
        <title><![CDATA[The association between digital literacy and cognitive function in older adults: the multiple mediating roles of self-efficacy, social participation, and psychological resilience]]></title>
        <pubdate>2026-09-04T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Rui Ren</author><author>Reyisaimu Wumaierjiang</author><author>Rui Li</author><author>Rui Hou</author><author>Kangjia Yang</author>
        <description><![CDATA[BackgroundDigital literacy refers to the ability to safely and effectively use digital technologies to access, manage, and apply information for daily living and social participation, and has been recognized as a key strategy for promoting healthy aging. However, limited research has simultaneously examined multiple psychosocial mechanisms underlying the relationship between digital literacy and cognitive function in older adults. This study aimed to examine the parallel mediating roles of self-efficacy, social participation, and psychological resilience in the relationship between digital literacy and cognitive function.MethodsA cross-sectional design was employed. We recruited older adults aged ≥60 years from a city in China to complete a questionnaire survey. The survey instruments included a general information questionnaire, the Digital Literacy Scale for Older Adults, the General Self-Efficacy Scale, the Social Participation Scale for Older Adults, the Brief Psychological Resilience Scale, and the Mini-Mental State Examination (MMSE). A multiple mediation model was constructed using structural equation modeling (SEM).ResultsAmong the 630 participants, the largest proportion of participants were aged 70–79 years (45.9%), and 52.1% were male. The mean MMSE score was 25.71 (SD = 3.38), indicating that the sample, on average, fell within the normal cognitive range (scores below 24 are typically considered indicative of mild cognitive impairment). Digital literacy was significantly correlated with cognitive function (r = 0.246, P < 0.01). The total effect of digital literacy on cognitive function was 0.347 (95% CI 0.258–0.417, P = 0.002). Mediation analysis revealed that digital literacy indirectly influenced cognitive function through three pathways: self-efficacy, social participation, and psychological resilience. The total indirect effect accounted for 39.5% of the total effect, and the direct effect accounted for 60.8%. Among the three mediating pathways, self-efficacy showed the strongest indirect effect (16.4%), followed by social participation (13.0%) and psychological resilience (10.1%).ConclusionDigital literacy not only shows a direct association with cognitive function in older adults but also shows indirect associations through self-efficacy, social participation, and psychological resilience. Therefore, multifaceted, synergistic interventions may be considered that integrate digital skills training with social engagement and psychological support are associated with cognitive health and the quality of life for older adults.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1975276</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1975276</link>
        <title><![CDATA[Correction: Acute changes in ankle dorsiflexor strength and fNIRS-derived cortical activation following a single session of neuromuscular electrical stimulation in healthy older adults]]></title>
        <pubdate>2026-09-03T00:00:00Z</pubdate>
        <category>Correction</category>
        <author>Yingqi Li</author><author>Luyi Wang</author><author>Congxiao Wang</author><author>Hujun Wang</author><author>Shaoting Zhang</author><author>Anda Xiu</author><author>Shengxuan Duan</author><author>Yingpeng Wang</author><author>Shuyan Qie</author>
        <description></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1925166</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1925166</link>
        <title><![CDATA[Peripheral adaptive immune remodeling associated with severe hearing loss in older adults: a single-center flow-cytometry study with mouse cochlear transcriptomic context]]></title>
        <pubdate>2026-09-03T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Qunhui Zhang</author><author>Wei Liu</author><author>Meijun Shao</author><author>Jinyu Wang</author><author>Qianyi Zhong</author><author>Linlan Jiang</author>
        <description><![CDATA[ObjectiveTo investigate the association between severe hearing loss and systemic immune aging in older adults using participant-level clinical immunophenotyping, and to explore potential inflammatory pathways and cellular contexts using public mouse cochlear transcriptomic data.MethodsWe analyzed a single-center cohort of 76 older adults, classified into normal hearing (NH), mild-to-moderate hearing loss (MMHL), or severe-to-profound hearing loss (SPHL) groups. Age- and sex-adjusted models were used to assess immune profiles. Prespecified sensitivity and diagnostic analyses evaluated age specification, overlap weighting, influential observations, and the stability of the inversion model. Additionally, public mouse cochlear bulk transcriptomics and single-nucleus RNA sequencing (snRNA-seq) data were examined to identify relevant inflammatory pathways and cell-type-specific immune-stress modules.ResultsSPHL was significantly associated with a higher T-cell/CD8 skew, increased CD4 differentiation, an elevated EM/naive CD4 balance, a lower CD8 activation/checkpoint score, and increased odds of CD4/CD8 inversion. These associations remained consistent across sensitivity analyses. Mouse bulk transcriptomics highlighted inflammatory response and IL6/JAK/STAT3 signaling pathways, while snRNA-seq localized immune-stress modules primarily to broad macrophage and perivascular macrophage-like cell populations.ConclusionSevere hearing loss in older adults is associated with distinct peripheral immune remodeling features indicative of systemic immune aging. These findings support an association-focused framework linking hearing loss severity with immune dysregulation, though validation in larger, clinically annotated cohorts is required.]]></description>
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