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        <title>Frontiers in Aging | New and Recent Articles</title>
        <link>https://www.frontiersin.org/journals/aging</link>
        <description>RSS Feed for Frontiers in Aging | New and Recent Articles</description>
        <language>en-us</language>
        <generator>Frontiers Feed Generator,version:1</generator>
        <pubDate>2026-05-13T16:09:39.525+00:00</pubDate>
        <ttl>60</ttl>
        <item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1773667</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1773667</link>
        <title><![CDATA[Nicotinamide riboside and pterostilbene reduces frequency and severity of undesirable symptoms of the menopause transition: an open-label, pilot clinical trial]]></title>
        <pubdate>2026-05-13T00:00:00Z</pubdate>
        <category>Clinical Trial</category>
        <author>Holly E. Holmes</author><author>Kamal Srivastava</author><author>Jennifer M. Scalici</author><author>Jyothi Dhuguru</author><author>Allyson E. Shea</author><author>Marie E. Migaud</author><author>Ryan W. Dellinger</author>
        <description><![CDATA[IntroductionNicotinamide adenine dinucleotide (NAD+) is a metabolite of vitamin B3 necessary for the production of key hormones like estradiol. Both NAD+ and estradiol levels decrease with age. Reduced estradiol levels have been associated with undesirable symptoms of the menopause transition. Previous clinical trials have demonstrated that oral supplementation with NRPT, a combination of the NAD+ precursor nicotinamide riboside (NR) plus pterostilbene (PT), significantly increases NAD+ levels. In the present study, the effects of a 7-day supplementation of NRPT on undesirable symptoms of the menopause transition were examined.MethodsAn open-label, pilot clinical trial (ClinicalTrials.gov identifier NCT04841499) was conducted to assess the efficacy of NRPT supplementation (commercially known as Basis; a combination of nicotinamide riboside and pterostilbene) in 40 healthy women over 35 years of age, 32 of which self-reported symptoms associated with the menopause transition (MS group) and eight women who were not experiencing any (or minimal) symptoms associated with menopause (No-MS group). All 40 women were given the recommended dose of NRPT (250 mg NR and 50  mg PT) daily for 7 days. A menopausal symptom survey was taken at baseline and at the end of the 7-day intervention. Urine was also collected at baseline and after 7 days to assess levels of estrone (E1) and estradiol (E2) and the changes in the vitamin B3 catabolome stemming from NRPT supplementation.ResultsAt the end of the study, significant decreases in both the frequency and magnitude of bloating, hot flashes, and poor sleep were reported in the MS group as compared to baseline. This was accompanied by a significant increase in the E2/E1 ratio. The No-MS group did not report any significant changes in these endpoints. As anticipated NRPT intake significantly increased urinary levels of methyl-nicotinamide (Me-NAM) as well as the methylated pyridone carboxamides (Me-PYs) in all groups. A significant time x menopausal status interaction was observed for nicotinuric acid (NUA). No other significant changes occurred for the other nicotinamide catabolites, such as nicotinamide N-oxide (NAM-N-Oxide), and a newly characterized NAD+ catabolite, N-methyl-nicotinuric acid (Me-NUA).DiscussionThis study demonstrates that NRPT is effective in significantly decreasing the frequency and magnitude of undesirable symptoms of the menopause transition and significantly increases the E2/E1 ratio in menopausal women.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1761876</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1761876</link>
        <title><![CDATA[Experiences and challenges of in-hospital rehabilitation exercise among older adults with hip fracture arthroplasty in a fast-track program: a qualitative study]]></title>
        <pubdate>2026-05-12T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Jianlin Ji</author><author>Endong Xie</author><author>Yan Li</author><author>Hanlin Yang</author><author>Ouyao Chen</author><author>Lili Chen</author><author>Qunfeng Lu</author>
        <description><![CDATA[IntroductionHip fractures are a major global health problem for older adults and fast-track programs are now widely used to improve outcomes. However, older adults following hip fracture arthroplasty often faced difficulties in rehabilitation exercise during hospitalization, and little is known about the factors shaping their exercise behaviors within fast-track care.ObjectiveThe purpose of this study is to explore the experiences, dilemmas, and needs related to in-hospital rehabilitation exercise among older adults following hip fracture arthroplasty in a fast-track program, to inform strategies for improving rehabilitation support and recovery. Methods: A qualitative interview study was conducted using purposive sampling at a tertiary hospital in Shanghai, China, from January to March 2025. Sixteen older adults with hip fracture arthroplasty aged 65–90 years were recruited. Interviews were audio-recorded, transcribed verbatim, uploaded into NVivo 15.0, and analyzed using thematic analysis.ResultsFour main themes during hospitalization rehabilitation within a fast-track program were identified: (1) Negotiating recovery motivation and rehabilitation-related vulnerability; (2) Disjunction between rehabilitation advice and patients’ understanding; (3) The double-edged role of social networks; (4) Unmet need for rehabilitation support.ConclusionThis study highlights the urgent need to optimize rehabilitation in older adults after hip fracture arthroplasty, particularly within fast-track care. Optimizing rehabilitation may therefore require greater attention to psychosocial support, clearer and more actionable education, and a more interactive rehabilitation environment, with strengthened involvement from nurses, family caregivers, and peers.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1831434</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1831434</link>
        <title><![CDATA[Social wellbeing in older breast cancer survivors taking adjuvant endocrine therapy: impacts of self-efficacy for symptom management and pain]]></title>
        <pubdate>2026-05-11T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Nicole A. Arrato</author><author>Addison D. Monroe</author><author>Francis J. Keefe</author><author>Gretchen G. Kimmick</author><author>Rebecca A. Shelby</author>
        <description><![CDATA[IntroductionFor older breast cancer survivors taking adjuvant endocrine therapy (AET), side effects are common and significantly impact quality of life. Self-efficacy is an important protective factor in this population, but little is known about its relationship to pain interference and social wellbeing. This study examined the relative contributions of self-efficacy for managing symptoms (SEMS) to objective and subjective pain interference and social wellbeing.MethodsFifty-one women aged ≥65 taking AET for breast cancer completed measures at the time of routine medical follow-up. The measures assessed SEMS, pain intensity, pain interference (subjective report and objective measurement, i.e., the timedup and go test), and social wellbeing.ResultsHierarchical regression analyses demonstrated that SEMS was significantly associated with social wellbeing, over and above pain-related variables. When examining pain interference as a subjective measure, pain interference was initially associated with social wellbeing (p = 0.001), but was no longer significant (p = 0.443) when SEMS (p < 0.001) was added into the model. When examining pain interference via objective measure, only SEMS was significantly associated (p < 0.001) with subjective and objective measures of pain interference and social wellbeing, over and above other factors.DiscussionResults highlight the importance of SEMS as a pathway to preserve social wellbeing and potentially minimize loneliness in older breast cancer survivors. Interventions which prioritize SEMS and address social wellbeing may also have downstream impacts on AET adherence, recurrence rates, and quality of life.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1794192</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1794192</link>
        <title><![CDATA[The microbiome-gerogene axis: a new frontier in precision geromedicine]]></title>
        <pubdate>2026-05-08T00:00:00Z</pubdate>
        <category>Review</category>
        <author>Jhommara Bautista</author><author>Andrés López-Cortés</author>
        <description><![CDATA[Aging is increasingly recognized as a biologically heterogeneous process arising from dynamic interactions among genetic programs, environmental exposures, and adaptive physiological responses. Within the geroscience framework, conserved hallmarks, including genomic instability, epigenetic alterations, mitochondrial dysfunction, chronic inflammation, cellular senescence, and dysbiosis, capture the systems-level nature of age-related decline. Parallel to this framework, the concept of gerogenes defines coordinated molecular programs that actively drive biological aging when persistently engaged, counterbalanced by gerosuppressive pathways that preserve resilience. Here, we synthesize evidence supporting a unifying microbiome-gerogene axis in which the gut microbiome functions as an upstream, modifiable regulator of molecular aging trajectories. Age-associated microbial remodeling leads to loss of beneficial metabolic functions, including short-chain fatty acid production, bile acid transformation, and mitochondrial-supportive co-metabolism, with downstream effects on epithelial barrier integrity, immune homeostasis, and tissue repair. Integrated multi-omics studies link these microbial changes to host transcriptional, epigenomic, proteomic, and metabolomic signatures of biological aging, enabling mechanistic insights beyond taxonomic associations. Immune aging represents a major convergence point of microbiome-gerogene crosstalk, as dysbiosis driven barrier dysfunction and microbial translocation reinforce inflammaging, immunosenescence, and senescence-associated signaling networks. In parallel, microbial metabolites interface with epigenetic regulation, mitochondrial quality control, circadian biology, and gut-brain-immune communication, extending microbial influence to systemic and neurodegenerative aging processes. Building on this mechanistic foundation, we propose the microbiome-gerogene axis as an integrative framework for precision geromedicine, linking lifestyle exposures to intracellular aging programs and informing biomarker discovery and personalized interventions aimed at extending healthspan rather than treating late-stage disease.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1765569</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1765569</link>
        <title><![CDATA[Rare and novel genetic variants in sporadic and familial Alzheimer’s disease: insights from the first Saudi cohort]]></title>
        <pubdate>2026-05-08T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Fadia El Bitar</author><author>Ghadeer Al Dawsari</author><author>Najeeb Qadi</author><author>Saad Al Rajeh</author><author>Mohamed Abouelhoda</author><author>Sahar Al Subaie</author><author>Nada Majrashi</author><author>Amna Magrashi</author><author>Hala Al Amari</author><author>Fatimah Alghamdi</author><author>Sara Abdulaziz</author><author>Bashayer Al-Mubarak</author><author>Nada Al Tassan</author>
        <description><![CDATA[BackgroundAlzheimer’s disease (AD) is a complex brain disorder that is greatly affected by genetics. Next-generation sequencing (NGS) has facilitated the discovery of rare variants in new genes that may be linked to AD in different populations. However, we still know very little about the genetic makeup of AD in Saudi Arabia and other Arab populations.ObjectivesThis study aims to explore rare variants that are predicted to be deleterious in a group of 64 Saudi patients diagnosed with sporadic and familial Alzheimer’s disease (AD). These patients previously tested negative for mutations in genes known to cause AD and were genotyped for APOE alleles.MethodsWe performed whole-exome sequencing (WES) on the Ion Proton platform. Then, we used our internal process for filtering, validating, and prioritizing variants.ResultsUsing stringent selection criteria, we identified 107 rare candidate variants with potential functional relevance. Of these, 26 (24.3%) were novel, while the remaining variants had been previously reported in public databases. Among these candidates, 33 were connected to AD, 28 to both AD and other neurodegenerative disorders (OND), 34 to OND-related functions, and 11 to broader processes like aging, inflammation, and neuronal regulation. We found rare missense variants in genes involved in important processes related to Alzheimer’s disease. These processes include mainly Aβ and Tau pathology, kinase signaling, stress response, and neuroinflammation.ConclusionOur analysis reveals diverse genetic contributors to Alzheimer’s disease in a population that remains largely underrepresented in genomic studies. We identified candidate variants in 53% of the patients, highlighting the value of expanding AD genetics research to non-European populations.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1802176</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1802176</link>
        <title><![CDATA[Modifiable lifestyle factors and 4.9-Year changes in phenotypic age in the Taiwan biobank]]></title>
        <pubdate>2026-05-07T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Wan-Yu Lin</author>
        <description><![CDATA[IntroductionPhenotypic age (PhenoAge) is a composite biomarker that reflects biological aging by integrating indicators of immune, metabolic, liver, and kidney function.MethodsUsing 4.9 years of follow-up data from 69,462 participants in the Taiwan Biobank, this study investigated lifestyle and environmental factors associated with changes in PhenoAge (ΔPhenoAge: follow-up minus baseline).ResultsPartial correlation analysis was first applied to evaluate 43 lifestyle factors. Fifteen factors were positively correlated with ΔPhenoAge, with obesity-related indices showing the strongest correlations. Nine factors were inversely correlated, including employment status and dietary habits. These variables were further evaluated using best-subset regression to identify the most relevant factors. In multivariable analyses, ΔPhenoAge in men was associated with living alone, higher body fat percentage, and larger waist circumference. In women, ΔPhenoAge was associated with daily supplement use, eating supper within 1 h of bedtime, and higher body mass index. Exposure to incense burning was associated with higher ΔPhenoAge in both sexes. Conversely, reduced consumption of fried foods, greater variety of vegetables, lower meat intake, and staying at the same job throughout the career were associated with lower ΔPhenoAge.DiscussionThese results suggest that several modifiable factors are associated with changes in biological aging, highlighting the importance of lifestyle for healthy aging.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1780260</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1780260</link>
        <title><![CDATA[eDEM-CONNECT: agitation ontology for the intelligent support of informal caregivers of people with dementia]]></title>
        <pubdate>2026-05-01T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Sumaiya Suravee</author><author>Christiane Pinkert</author><author>Iris Hochgraeber</author><author>Margareta Halek</author><author>Bernhard Holle</author><author>Kristina Yordanova</author>
        <description><![CDATA[People with dementia (PwD) face cognitive decline, placing added stress on family caregivers. Challenging behaviour, such as agitation, is one of the prominent behaviours exhibited by PwD, and family caregivers are often faced with the challenge of finding an appropriate intervention strategy to cope with it. To address this problem, current research focuses on developing digital solutions for the support of unprofessional caregivers, allowing them to ease the stress factor while dealing with agitation. A major challenge in any digital solution is the required domain knowledge. This knowledge includes information about the types of agitated behaviour, living and socio-economic conditions of the PwD and non-pharmaceutical interventions, which the caregiver can apply. We refer to this structured knowledge as an ontology. This study focuses on the development of the eDEM-Connect Ontology: Ontology of Dementia-related Agitation and Relationship between Informal Caregivers and Persons with Dementia (EDEM-CONNECTONTO) as the formalised domain knowledge for providing adequate support to caregivers. The knowledge is elicited through a systematic literature review, analysis of existing ontologies, workshops with experts, and interviews with informal caregivers. EDEM-CONNECTONTO consists of 252 Concepts, 16 relations, and 241 individuals. The ontology is implemented in the Web Ontology Language (OWL) and validated with the Protégé ontology development software. The results from the evaluation show that it meets the standard for biomedical ontologies. Furthermore, EDEM-CONNECTONTO is applied in several tasks related to the development of digital support systems for caregivers of PwD, demonstrating its practical applicability within the domain. The proposed ontology provides a structured semantic foundation for ontology-guided data annotation, knowledge graph construction, and GraphRAG-based caregiver-support applications. By formally modelling types of agitation, causes, consequences, PwD-caregiver relations, and non-pharmacological interventions, EDEM-CONNECTONTO enables explainable digital tools that support informal caregivers in identifying agitation patterns and selecting appropriate care strategies, thereby contributing to improved caregiver support and reduced caregiving stress.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1859857</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1859857</link>
        <title><![CDATA[Editorial: Enhancing geriatric care with AI: strategies for fall prevention and aging-in-place]]></title>
        <pubdate>2026-05-01T00:00:00Z</pubdate>
        <category>Editorial</category>
        <author>Siu Shing Man</author><author>Ronggang Zhou</author><author>Lu Peng</author><author>Alan Hoi Shou Chan</author>
        <description></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1752530</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1752530</link>
        <title><![CDATA[Therapeutic potential of stem cell-derived extracellular vesicles in aging and regeneration]]></title>
        <pubdate>2026-04-30T00:00:00Z</pubdate>
        <category>Review</category>
        <author>Isobel K. Dunstan</author><author>Daniel C. Anthony</author><author>Francesca Lugarini</author><author>Sherif Idriss</author>
        <description><![CDATA[Aging is characterized by measurable reductions in tissue repair, immune balance, and metabolic regulation. Increasing evidence suggests that these changes may arise, in part, from an insufficiency or altered quality of endogenous extracellular vesicle (EV) signaling. EVs, including exosomes, carry regenerative and immunoregulatory cues, and age-related alterations in their abundance, cargo, and bioactivity have been linked to impaired cellular communication across organ systems. This has fueled growing interest in stem cell-derived EVs, which provide biologically more youthful vesicles that reproduce key paracrine functions of their parent cells while avoiding the limitations of cell transplantation. By transferring defined protein, lipid, and RNA cargoes, these vesicles influence pathways central to aging biology, including mitochondrial function, inflammatory control, and maintenance of stem cell niches. Preclinical studies support their efficacy in models of neurodegeneration, wound healing, musculoskeletal decline, and systemic inflammation. However, their function depends on stem cell origin, donor age, and environmental conditioning, variables that complicate standardization and clinical scalability. As interest expands across therapeutic and cosmetic domains, a comparative understanding of EV sources and their mechanistic actions is required. In this review, we examine stem cell-derived EVs across biological sources, outline how aging and environmental factors shape their regenerative potency, and evaluate current progress in clinical translation. The field has reached a point where future advances depend less on further demonstrations of efficacy and more on resolving challenges related to manufacturing, quality control, and regulatory alignment. Addressing these constraints will determine whether stem cell-derived EVs can progress from experimental promise to practical interventions for aging and regenerative medicine.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1855184</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1855184</link>
        <title><![CDATA[Editorial: Women at the forefront of musculoskeletal aging science]]></title>
        <pubdate>2026-04-30T00:00:00Z</pubdate>
        <category>Editorial</category>
        <author>Caglar Cosarderelioglu</author><author>Stefania Toselli</author><author>Ligiana Pires Corona</author>
        <description></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1824237</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1824237</link>
        <title><![CDATA[Sex differences in mitochondrial function in aging mouse skeletal muscle]]></title>
        <pubdate>2026-04-29T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Angelina Holcom</author><author>Ashley Liao</author><author>Kaitlyn G. Holden</author><author>Anne M. Bronikowski</author><author>Ashley E. Webb</author>
        <description><![CDATA[IntroductionSex differences in lifespan and age-associated phenotypes are pervasive across species, yet the mechanisms remain poorly understood. Mitochondrial dysfunction is a major hallmark of aging, but whether skeletal muscle mitochondria age along sex specific trajectories remains incompletely defined.MethodsHere, we profiled mitochondrial bioenergetics and DNA integrity in flexor digitorum brevis (FDB) muscle from young (3–4 months) and aged (20–24 months) male and female C57BL/6 mice. We quantified cellular respiration in intact myofibers, measured mitochondrial DNA (mtDNA) copy number, and assessed expression of genes involved in mitochondrial dynamics, electron transport chain (ETC) function, and mtDNA maintenance.ResultsCellular respiration differed by sex at baseline and changed with age in a sex-dependent manner. Aged females exhibited a lower basal and ATP-linked respiration than aged males. In contrast, spare respiratory capacity increased in aged females relative to aged males, consistent with age- and sex-specific remodeling of the bioenergetic reserve. mtDNA copy number increased with age in both sexes, with a greater increase in mtDNA content in aged males. Gene-expression analyses revealed age- and/or sex-dependent changes, including lower Pink1 expression in females compared to males, an age-related increase in the mtDNA maintenance gene Polg2 only in males, though most genes were not significantly different. As an exploratory systemic readout, we additionally assessed DNA damage responsiveness in whole-blood leukocytes using the alkaline comet assay following oxidative challenge; young females exhibited greater induced DNA damage than young males.DiscussionTogether, these data define sex- and age-associated mitochondrial remodeling in FDB and provide an initial assessment of sex-dependent inducible DNA damage responses in blood, underscoring the importance of sex as a biological variable in studies of aging.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1805946</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1805946</link>
        <title><![CDATA[Utilizing age-friendly cities and communities to support access to vaccination, vision, hearing and oral healthcare]]></title>
        <pubdate>2026-04-29T00:00:00Z</pubdate>
        <category>Perspective</category>
        <author>Cera Cruise</author><author>Katrina Bouzanis</author><author>Anna Sangster</author><author>Sarah Hyeon-A. Kim</author><author>Jane Barratt</author>
        <description><![CDATA[Population aging is a global phenomenon, resulting in increasing numbers of older people. As populations age, the prevalence of noncommunicable diseases and sensory loss also increases. These challenges create an imperative to maintain health across the life course, to reap the benefits of longer lives and reduce the burden on health and social systems. Functional ability is shaped by the individual and the environment in which people live. The World Health Organization’s Age-friendly Cities Framework defines an age-friendly city as one that adapts its structures and services to be accessible to and inclusive of older people with diverse needs and capacities and is guided by eight domains, including community support and health services. Despite the linkage between age-friendly environments and health, the Age-Friendly Cities Framework can be better harnessed to support promoting access to health services which contribute to function but are not always central to health planning: immunization, and vision, hearing and oral care. Examination of 59 strategy and action plans submitted by members of the Global Network of Age-Friendly Cities and Communities (GNAFCC) indicates that only 18 out of 59 cities and communities included health actions to support vaccination, hearing, vision and oral health in their age-friendly plans. This article explores the importance of these interventions to healthy aging, the extent to which age-friendly cities and communities support access to these health services within their plans and how age-friendly planning may be utilized as a tool to enhance comprehensive access to immunization, vision, hearing and oral care.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1748389</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1748389</link>
        <title><![CDATA[Vitamin D, systemic inflammation, and motoric cognitive risk: exploring the risk factors and mediation pathways]]></title>
        <pubdate>2026-04-28T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Yunhe Xu</author><author>Pei Qin</author><author>Ningqi Kang</author><author>Ying Li</author><author>Lijiao Wang</author>
        <description><![CDATA[IntroductionMotoric cognitive risk (MCR) syndrome, defined by subjective cognitive complaints and slow gait, is a predementia condition associated with multiple adverse outcomes. Although vitamin D deficiency and systemic inflammation have been implicated in cognitive and motor decline, their interaction in the context of MCR remains unclear.MethodsThis cross-sectional study included 312 hospitalized adults aged ≥60 years. Serum 25(OH)D levels, systemic immune-inflammation index (SII), and standardized clinical assessments were obtained within 48 h of admission. Multivariable regression and mediation analyses were performed to evaluate associations and underlying pathways.ResultsThe prevalence of MCR was 17.9%. Older age, greater comorbidity burden, poor sleep quality, lower 25(OH)D levels, and higher SII were independently associated with MCR. Mediation analysis showed that systemic inflammation accounted for approximately one-quarter of the association between lower 25(OH)D and higher MCR risk, with the strongest indirect effect observed at 25(OH)D ≤ 20 ng/mL.DiscussionVitamin D deficiency and systemic inflammation are important determinants of MCR. The identified vitamin D–inflammation pathway may contribute to motoric cognitive vulnerability and provide insights for early risk stratification and preventive strategies in geriatric populations.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1813024</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1813024</link>
        <title><![CDATA[Association between loneliness and social isolation and health outcomes among cancer survivors and non-cancer controls]]></title>
        <pubdate>2026-04-28T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Nancy E. Avis</author><author>Sybil Crawford</author><author>Alicia Colvin</author>
        <description><![CDATA[IntroductionThe present analyses take advantage of an existing cohort of cancer survivors (cases) and women without a history of cancer (controls) to examine whether older cancer survivors experience greater loneliness or social isolation than women without a history of cancer and how loneliness and social isolation are related to health outcomes.MethodsCross-sectional analyses were conducted from Visit 17 of The Study of Women’s Health Across the Nation (SWAN), a multiracial/ethnic cohort study initiated to study the biological and psychosocial changes occurring during the menopausal transition. We identified 276 women who had developed cancer over the 30 years of SWAN (eligible cases) and 1,123 women who never had cancer. Loneliness was measured using the UCLA 3-item loneliness scale. Social isolation was assessed with a modified version of the Social Network Index. Outcomes included health-related quality of life (HRQL) as assessed by the SF-36 (MCS and PCS), depressive symptoms (CES-D), and anxiety. Covariates included sociodemographic, health-related, and psychosocial variables. Associations of case-control status, years since diagnosis in cases, loneliness, and social isolation with MCS and PCS were estimated using analysis of covariance, and with depressive symptoms and high anxiety using logistic regression. Effect modification of loneliness and social isolation by case-control status was assessed by adding relevant interaction terms to models.ResultsCase-control status was not significantly related to loneliness or social isolation. Loneliness and social isolation were negatively related to PCS before, but not after covariate adjustment. Corresponding negative associations with MCS remained statistically significant after covariate adjustment. Loneliness and social isolation were positively associated with depressive symptoms. Loneliness, but not social isolation, was positively associated with high anxiety. With the exception of a significantly stronger unadjusted association of PCS with loneliness in controls than in cases, there was no statistically significant effect modification by case-control status before or after covariate adjustment.ConclusionNeither loneliness nor social isolation was related to cancer survivorship status. Although both loneliness and social isolation were related to HRQL and mental health outcomes in a cohort of older women, these associations were similar for cancer survivors and those without a history of cancer.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1782176</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1782176</link>
        <title><![CDATA[Living alone and risk of dementia, cognitive decline, and institutionalization in the MEMENTO cohort]]></title>
        <pubdate>2026-04-28T00:00:00Z</pubdate>
        <category>Brief Research Report</category>
        <author>Dominique Huvent-Grelle</author><author>Jean Baptiste Beuscart</author><author>Audrey Hubert</author><author>Vincent Bouteloup</author><author>Philippe Amouyel</author><author>François Puisieux</author><author>Aghiles Hamroun</author><author>Estelle Aymes</author>
        <description><![CDATA[IntroductionAlzheimer’s disease and related dementias (ADRD) represent a public health challenge, with prevention strategies focusing on modifiable risk factors such as isolation. Living alone is used as a proxy for social isolation, although its relationship with ADRD outcomes remains unclear, partly due to the distinction between objective isolation and subjective loneliness. This study examined the association between living alone and the risk of dementia, cognitive decline, and institutionalization in the MEMENTO cohort, a French clinic-based study of individuals with cognitive complaints or mild cognitive impairment.MethodsLiving alone at baseline was the main exposure. Perceived isolation was assessed using self-reported measures. Outcomes included incident dementia, institutionalization; and trajectories of Mini-Mental State Examination (MMSE) scores over a 5-year median follow-up. Cause-specific Cox models accounting for competing risks were used for dementia and institutionalization, and linear mixed models for MMSE trajectories.ResultsAmong 2,269 participants (median age 71.5 years, 62% women, median MMSE 28), 30.7% lived alone and 6.5% reported perceived isolation. At 60 months, estimated cumulative incidences were 15% for dementia, 1.0% for institutionalization and 3.6% for death. Living alone was not associated with incident dementia (HR = 0.88 [95%CI: 0.67–1.16], p = 0.38), or cognitive decline. In contrast, it was associated with a higher risk of institutionalization (HR = 3.21 [95%CI: 1.09–9.48], p = 0.03).DiscussionLiving alone was not linked to dementia risk or cognitive decline, but was associated with a higher risk of institutionalization. This finding may indicate that living alone captures vulnerability related to reduced day-to-day support rather than cognitive decline itself.]]></description>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1696711</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1696711</link>
        <title><![CDATA[Glycemic dysregulation and cognitive impairment in aging adults: a cross-sectional study with amyloid biomarker correlation]]></title>
        <pubdate>2026-04-28T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>R. Rajalakshmi</author><author>C. M. Ramya</author><author>Rimshia Naaz</author><author>SubbaRao V. Madhunapantula</author><author>Chinnappa A. Uthaiah</author><author>Paramahans V. Salimath</author>
        <description><![CDATA[BackgroundType 2 Diabetes Mellitus (T2DM) is a rising health concern, particularly affecting the elderly population. Beyond its well-established metabolic consequences, growing evidence suggests a strong association between type 2 diabetes mellitus and cognitive decline. The core features of diabetes, viz., chronic hyperglycemia and insulin resistance (IR), not only contribute to the neurodegenerative changes in the brain but also promote the generation and accumulation of amyloid-β (a hallmark feature in Alzheimer’s disease). These molecular changes triggered by T2DM play a pivotal role in the onset of cognitive damage. In this study, we have explored the interplay between glycemic status, cognitive performance, and plasma amyloid-β (Aβ) levels in an ageing population.MethodologyA cross-sectional study was conducted among 396 individuals aged 51–80 years. Based on their HbA1c levels, the study participants were categorized into four glycemic groups: individuals without diabetes, individuals with prediabetes, individuals with diabetes, and individuals with uncontrolled diabetes. Cognitive function was evaluated using the Modified Mini-Mental State Examination (3MSE). Fasting glucose, insulin, Homeostatic Model Assessment (HOMA)-IR, lipid profiles, and plasma Aβ 1–40 and Aβ 1–42 were measured. Statistical analyses were carried out using Chi-square tests, logistic regression, Spearman correlation, and Receiver Operating Characteristic (ROC) curve analysis.ResultsA comparative assessment in the study revealed the prevalence of cognitive impairment across all glycemic groups, with 40.15% of participants overall affected. It was observed that the prevalence increased with the glycemic index, with 26.97% of individuals without diabetes affected, 35.92% of individuals with prediabetes, 55.03% of individuals with diabetes under control, and 70.91% of individuals with uncontrolled diabetes (p < 0.001). Logistic regression indicated progressively higher odds of cognitive impairment with worsening glycemic control (OR for individuals with uncontrolled diabetes ≈6.87, p < 0.001). Age and HbA1c were significantly inversely correlated with 3MS scores. Plasma Aβ 1–40 and Aβ 1–42 levels were elevated in individuals with diabetes groups, while the Aβ 1–42/Aβ 1–40 ratio was positively associated with cognitive performance. The ROC curve analysis of the logistic regression indicated an Area Under Curve (AUC) of 0.76, suggesting good predictive capability.ConclusionImpaired glycemic status was found to be strongly associated with increased cognitive decline, alongside altered amyloid biomarker profiles, in elderly populations. These findings suggest the heightened importance of metabolic homeostasis and also underscore the critical need for early metabolic interventions and cognitive screening in the individuals with diabetes to mitigate the risk of early neurodegeneration.]]></description>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1828980</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1828980</link>
        <title><![CDATA[Editorial: Alleviating age-related disease burden]]></title>
        <pubdate>2026-04-28T00:00:00Z</pubdate>
        <category>Editorial</category>
        <author>Matthew Halma</author><author>Sidra Hassaan</author><author>Jack A. Tuszynski</author>
        <description></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1787365</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1787365</link>
        <title><![CDATA[Interviews of community-dwelling older persons in Greece on healthy aging and wellbeing during multiple crises (the HAiG study)]]></title>
        <pubdate>2026-04-23T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>A. A. Mallidou</author><author>E. Zioga</author><author>A. Magripi</author><author>E. Roditi</author><author>F. D. Provida</author><author>Th. P. Apostolidi</author><author>I. V. Papathanasiou</author><author>P. Sourtzi</author>
        <description><![CDATA[BackgroundHealthy aging is a key priority in society, research, policy, and practice. Older people can continue contributing to society if they are healthy, empowered, financially secured, engaged in social activities, and have a sense of purpose.PurposeThe aim in this study was to explore and understand older people’s perceptions and experiences about healthy aging and wellbeing during multiple crises to support community cohesion and encourage relevant policies.MethodsIn 2023, a convenience sample of 58 older people living in urban and rural regions in Greece were interviewed. A content analysis was performed using the collected data.ResultsThree themes and five subthemes emerged from the data: a. financial stability, where employment was a subtheme for financial stability and security; b. sociopolitical environment; and c. personal choices, which included the four subthemes of healthy lifestyle, family, social engagement, and personal development.DiscussionGreek older people’s perceptions on healthy aging and wellbeing focused on financial security, the sociopolitical environment, and personal choices for healthy lifestyle and family relationships. The findings indicate the value of implementation of policy initiatives for building a society for all ages and improving older people’s lives and their contribution to society.]]></description>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1779773</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1779773</link>
        <title><![CDATA[Investigating the research trajectory and future trends in type 2 diabetes mellitus and aging: a bibliometric analysis from 2009 to 2025 based on big data]]></title>
        <pubdate>2026-04-22T00:00:00Z</pubdate>
        <category>Review</category>
        <author>Tingting Gong</author><author>Wei Jiang</author><author>Yiman Han</author><author>Yang Liu</author><author>Wuhui Zhuo</author><author>Shengyao Li</author><author>Zhipeng Hu</author><author>Zixi Zeng</author><author>Rensong Yue</author><author>Maoyi Yang</author>
        <description><![CDATA[BackgroundThe relationship between type 2 diabetes mellitus (T2DM) and aging has attracted growing scientific attention. Growing evidence suggests that T2DM is not only a metabolic disorder but also a condition associated with accelerated biological aging. This study aimed to systematically map the global research landscape, intellectual structure, and emerging trends at the intersection of T2DM and aging using bibliometric approaches.MethodsPublications indexed in the Web of Science Core Collection from 1 January 2009 to 31 December 2025 were retrieved, yielding 3,048 records. Bibliometric analyses were conducted using VOSviewer, CiteSpace, and R to construct collaboration networks, co-citation structures, and keyword evolution patterns.ResultsAfter a moderate growth phase from 2011 to 2015, publication output increased markedly from 2016 onward and reached a peak in 2025, accompanied by the progressive formation of an international collaboration network dominated by the United States and China. Mechanistic studies constituted the primary research focus, particularly those related to cellular senescence, oxidative stress, and inflammation. Cellular senescence emerged as a structurally central node within the knowledge network. Thematic evolution analysis further revealed increasing attention to aging-related comorbidities, including cardiovascular disease, Alzheimer’s disease, erectile dysfunction, and cognitive impairment. Recent research fronts have increasingly focused on molecular pathways, including the senescence-associated secretory phenotype, the NLRP3 inflammasome, and epigenetic regulation.ConclusionThis bibliometric analysis provides a comprehensive overview of the evolving research landscape linking T2DM and aging. The prominence of senescence-related pathways highlights a growing convergence between diabetes research and aging biology. Emerging strategies targeting fundamental aging mechanisms—including senolytic therapies and glucose-lowering drugs with potential geroprotective effects such as metformin and empagliflozin—represent promising directions for future research.]]></description>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1642652</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1642652</link>
        <title><![CDATA[Medication adherence in older adults with chronic diseases: a scoping review of barriers, facilitators, and effective interventions]]></title>
        <pubdate>2026-04-20T00:00:00Z</pubdate>
        <category>Review</category>
        <author>Doris Cardona-Arango</author><author>Valeria Santacruz-Restrepo</author><author>Alejandra Rendón-Montoya</author><author>Juliana Madrigal-Cadavid</author><author>Alejandra Segura-Cardona</author><author>Jorge Iván Estrada-Acevedo</author>
        <description><![CDATA[ObjectiveMedication adherence in older adults with chronic diseases is a public health challenge, given the growing and irreversible aging of the population, with direct repercussions on clinical outcomes and collective wellbeing. This scope review seeks to identify the main barriers and facilitators of pharmacological adherence and effective evidence-based interventions to optimize it.MethodsA scope review was conducted for the period 2015–2025. Forty-one observational and interventional scientific studies (clinical trials) were selected from PubMed, Scopus, Web of Science, and ScienceDirect. Initially, a search was performed in six databases covering public health, medicine, life sciences, and biomedicine (PubMed and ScienceDirect), evidence-based healthcare (Cochrane Library), social sciences, arts, and humanities (Scopus and Web of Science), and research output, with an emphasis on Latin America, Spain, and Portugal. The four databases with the largest number of publications on the older adult population were selected, including topics such as medication adherence (compliance with pharmacological treatment and prescribing recommendations), medication persistence (uninterrupted continuity in medication recovery and administration), and patient prioritization interventions using automated mechanisms. The final selection of articles was carried out by three experts, who performed a critical appraisal of the evidence. The discrepancies were resolved by two other researchers, following the identification, screening, selection and inclusion phases of the PRISMA-2020 guidelines. The analysis of the information was carried out through synthesis and narrative integration.ResultsIndividual barriers were identified, including demographic (age, sex, educational level, and income), psychological (anxiety, depression, and self-efficacy), cultural (beliefs, fatalism, and stigmas), physical and mental health status (multimorbidity and cognitive impairment), and pharmacological (number of medications and adverse effects) factors. Facilitators identified are related to the health system (continuity of care, fragmentation of care, assertive communication, access, and provision of medicines). The interventions include personalized health education.ConclusionMedication adherence in older adults should be addressed with comprehensive and sustainable interventions. These interventions combine pharmacist education, technological support, continuous monitoring, and patient participation in therapeutic decision-making. Strategies should be designed with a collaborative approach involving patients, families, and healthcare professionals, ensuring measurable clinical outcomes and improving their quality of life.]]></description>
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