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        <title>Frontiers in Aging | Interventions in Aging section | New and Recent Articles</title>
        <link>https://www.frontiersin.org/journals/aging/sections/interventions-in-aging</link>
        <description>RSS Feed for Interventions in Aging section in the Frontiers in Aging journal | New and Recent Articles</description>
        <language>en-us</language>
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        <pubDate>2026-08-19T15:50:12.202+00:00</pubDate>
        <ttl>60</ttl>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1856979</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1856979</link>
        <title><![CDATA[A minimal three-arm oral regimen for healthspan: mechanistic alignment with transcriptomic signals from a large parental-lifespan GWAS]]></title>
        <pubdate>2026-08-19T00:00:00Z</pubdate>
        <category>Hypothesis and Theory</category>
        <author>Ngo Cheung</author>
        <description><![CDATA[A large genome-wide association study of parental lifespan was reported in 2019. A later transcriptome-wide association study (TWAS) based on those summary statistics identified a set of transcriptional programs associated with longer genetically predicted survival, including increased brain NAD + salvage, especially NMNAT2, reduced glucose-stimulated insulin secretion, a shift toward synaptic pruning with less broad plasticity, and a glial pattern characterized by relatively greater microglial and lower astrocytic signatures, with only weak pan-tissue senescence signals. Building on those directional findings, this short communication proposes a minimal three-arm oral regimen with unequal evidentiary weight: first, the Cheung Glutamatergic Regimen, consisting of low-dose dextromethorphan potentiated by a CYP2D6 inhibitor together with piracetam and L-glutamine, as an exploratory adjunct aimed at preserving residual functional connectivity; second, daily nicotinamide mononucleotide and N-acetylcysteine with pulsed senolytics for NAD + salvage and senescence modulation; and third, GLP-1 receptor agonism for metabolic reprogramming. The NAD+/senescence arm is the primary mechanistic anchor, GLP-1 receptor agonism provides secondary metabolic support, and the glutamatergic arm is exploratory. Each arm targets a separate node within the pruning-plasticity-metabolic triad. The regimen is fully oral, uses conservative dosing, and draws on prior therapeutic or human-exposure data, although the proposed combination has no established safety profile. Although direct combination data are lacking and the foundational TWAS remains a preprint, the components show plausible but uneven mechanistic alignment with the TWAS signals and may justify carefully designed, safety-focused pilot evaluation.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1898942</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1898942</link>
        <title><![CDATA[Editorial: Nutritional strategies for enhancing longevity and healthy aging]]></title>
        <pubdate>2026-08-18T00:00:00Z</pubdate>
        <category>Editorial</category>
        <author>Pintu Choudhary</author><author>Pratik S. Gaikwad</author><author>Harsh B. Jadhav</author>
        <description></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1734620</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1734620</link>
        <title><![CDATA[Baseline cognitive status and adherence are associated with cognitive change following language learning in older adults: an exploratory study]]></title>
        <pubdate>2026-08-17T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Ladan Ghazi Saidi</author><author>Zoha Deldar</author><author>Ricardo Carrillo-Meza</author><author>Kiley Allgood</author><author>Alison Gansemer</author><author>Mariah Gentz</author><author>Amor Sofia Calderón-Hernández</author><author>Yunju Im</author><author>Cary R. Savage</author><author>Douglas H. Schultz</author>
        <description><![CDATA[IntroductionGiven cognitive benefits observed in lifelong bilinguals, a key question is whether L2 learning can boost cognition in later life.MethodsIn a pre–post intervention study, we assessed cognitive effects of learning a new language in older adults as measured by global cognition and domain-specific cognitive tests.Results and DiscussionWhile the MMSE, MoCA, and domain-specific measures (Stroop, Simon, nonword repetition, phonemic fluency, and semantic fluency) did not show significant whole-group pre-post change, a number of individual participants improved on all or some of these measures. Further, both linear regression and machine learning models indicated that participants with lower baseline scores on the MMSE, MoCA, phonemic fluency, and semantic fluency showed greater improvement in post-intervention measurements, reflecting greater cognitive gains, with phonemic fluency emerging as the best predictor of intervention outcome. A post hoc, adherence-sensitive analysis further indicated a +1.225-point MoCA advantage in completers relative to non-completers, consistent with an adherence-associated pattern. Machine learning analyses confirmed that cognitive gains were heterogeneous across participants and that the most responsive outcomes were reaction-time-based executive measures, particularly the Stroop task and Symbol Digit Substitution Test (SDST). Cluster analysis showed that the top improver profile combined lower baseline executive performance with markedly higher engagement and lesson completion.ConclusionThese results provide preliminary evidence that engagement in a structured and sustained L2-learning program may be associated with measurable pre–post cognitive changes in some older adults, especially when baseline performance leaves room for improvement. Further, high intervention adherence and engagement are critical to the extent of cognitive benefits derived from L2 learning interventions. Clinically, structured language learning programs that emphasize adherence, dose, and fidelity appear promising for older adults, especially those with emerging decline. These results are noteworthy, given the scarcity of effective options to improve cognitive health in aging, and the fact that L2 learning is low-cost and broadly accessible.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1834323</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1834323</link>
        <title><![CDATA[From obesity to healthy longevity: a consensus-based clinical framework for diagnosis, staging, and treatment]]></title>
        <pubdate>2026-08-14T00:00:00Z</pubdate>
        <category>Review</category>
        <author>Silvija Canecki-Varžić</author><author>Ines Bilić-Ćurčić</author><author>Maja Bakula</author><author>Tomislav Bulum</author><author>Maja Čavlović</author><author>Diana Delić-Brkljačić</author><author>Tamara Turk Wensveen</author><author>Daniela Fabris-Vitković</author><author>Dubravka Jurišić-Eržen</author><author>Sanja Klobučar</author><author>Kristina Kljajić</author><author>Mladen Krnić</author><author>Blaženka Miškić</author><author>Nataša Moser</author><author>Božidar Novoselović</author><author>Ivan Pećin</author><author>Tina Tičinović-Kurir</author><author>Jelena Vučak-Lončar</author><author>Marina Gradišer</author><author>Maja Cigrovski Berković</author><author>Gorana Mirošević</author><author>Kristina Selthofer-Relatić</author><author>Miro Bakula</author>
        <description><![CDATA[BackgroundObesity is a chronic, progressive, relapsing disease characterized by excess or dysfunctional adiposity that impairs health and contributes to multimorbidity, disability, and reduced life expectancy. Contemporary international frameworks recommend moving beyond BMI-only definitions toward disease-based diagnostic models that integrate adiposity, complications, and functional status. Croatia faces a high prevalence of obesity alongside constrained healthcare resources and limited reimbursement for modern pharmacotherapy, highlighting the need for nationally adapted clinical guidance.MethodsThis position statement was developed using a modified Delphi consensus process involving 23 multidisciplinary experts from academic and clinical institutions across Croatia. Consensus statements were derived from contemporary international guidelines, randomized controlled trials, and meta-analyses. Evidence quality and recommendation strength were graded using an adapted GRADE-based framework.ResultsThe document establishes a Croatia-specific framework for the diagnosis, staging, and management of obesity. Diagnosis requires confirmation of excess adiposity with evidence of clinical risk or dysfunction and integrates anthropometric measures with metabolic, mechanical, psychological, and functional domains. A staging system aligned with EASO and Lancet frameworks guides treatment intensity according to disease severity. Management is based on four pillars: lifestyle therapy, psychological support, pharmacotherapy, and metabolic/bariatric surgery. Pharmacological treatment is stage-based and comorbidity-driven, prioritizing agents with proven organ-protective effects. Special considerations are provided for older adults, emphasizing preservation of muscle mass, functional capacity, independence, and quality of life. Long-term structured follow-up is recommended for all patients, reflecting the chronic disease model of obesity.ConclusionThis position statement provides an evidence-based, nationally adapted clinical framework that aligns obesity management with modern chronic disease standards. By integrating disease staging, individualized therapy, and long-term care, it supports precision treatment across the lifespan and emphasizes obesity management as a key strategy for preventing complications, reducing disability, and promoting healthy longevity.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1847451</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1847451</link>
        <title><![CDATA[Physical exercise for prevention of dementia study: a 48-month randomized controlled trial]]></title>
        <pubdate>2026-08-10T00:00:00Z</pubdate>
        <category>Clinical Trial</category>
        <author>Enzo Iuliano</author><author>Giovanni Fiorilli</author><author>Antonella Angiolillo</author><author>Graziamaria Corbi</author><author>Giulia Di Martino</author><author>Santina Ciccotelli</author><author>Carlo della Valle</author><author>Giuseppe Calcagno</author><author>Alessandra di Cagno</author><author>Alfonso Di Costanzo</author>
        <description><![CDATA[BackgroundAlthough multimodal exercise interventions are recognized for their potential to attenuate age-related cognitive decline, the current literature lacks longitudinal depth. Specifically, robust randomized evidence addressing the long-term efficacy of structured training protocols remains limited. This single-blind RCT involved 882 community-dwelling older adults categorized as healthy, having subjective memory complaints (SMCs), or having mild cognitive impairment (MCI).MethodsParticipants were randomized to an experimental group (EG), performing 48 months of supervised moderate-to-high-intensity multimodal training (aerobic, resistance, and stretching), or to a control group (CG), maintaining usual habits. The primary outcome was the 48-month change in Mini-Mental State Examination (MMSE) scores. Secondary outcomes were scores on eight neuropsychological tests assessed at 12, 24, 36, and 48 months. A linear mixed-effects model analysis with repeated measures (LMM) was used to evaluate significant differences between the CG and EG.ResultsIn the final analysis of 674 participants, healthy participants (between-group effect: p = 0.008; η2p = 0.007; time*group interaction: p < 0.001; η2p = 0.025) in the EG showed significantly higher MMSE scores than those in the CG. SMC participants in the EG also showed higher MMSE scores than those in the CG (between-group effect: p = 0.052; η2p = 0.004; time*group interaction: p < 0.001; η2p = 0.031), although the between-group difference only approached statistical significance. Similarly, healthy and SMC participants in the EG demonstrated significantly better performance in the secondary outcomes of memory, attention, and reasoning than those in the CG. The sample size of the MCI group was insufficient to allow for conclusive statistical analyses.ConclusionA 48-month multicomponent exercise program significantly improved cognitive performance in healthy and SMC older adults. Structured physical activity may effectively slow cognitive decline.Clinical Trial Registrationhttps://clinicaltrials.gov/study/NCT02236416. Identifier number: NCT02236416.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1886928</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1886928</link>
        <title><![CDATA[Guided positional stabilization: a hypothesis on the role of targeted interfaces in enhancing upright stability among frail older adults]]></title>
        <pubdate>2026-08-03T00:00:00Z</pubdate>
        <category>Hypothesis and Theory</category>
        <author>Mayur Bhatt</author><author>Harikrashna Bhatt</author>
        <description><![CDATA[Elderly adults are at a higher risk of falls due to many reasons including issues in balance, coordination and overall sensory responsiveness. Falls ultimately threaten health and result in the fear of falling this causes restricted mobility and further decrease in health. Although there are traditional interventions such as railings, walkers or balance therapy which aim to reduce falls, they often function on compensatory mechanisms with little for postural regulation. We hypothesize that Guided Positional Stabilization (GZ) which use light strategically situated contact interfaces, can improve upright stability in frail elderly individuals by stimulating proprioceptive and tactile pathways. GZ is not a support aid rather a neurosensory framework that engages the nervous system in reactive and anticipatory balance corrections. Learning from concepts in biomechanics, neuroscience and geriatrics, this article presents the design requirements, theory, and possible clinical applications of GZ in fall prevention. We also put forward a pilot research agenda for testing the effectiveness of GZ in real world environments.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1793208</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1793208</link>
        <title><![CDATA[Promoting physical activity and physical functioning among residents in nursing homes – lessons learnt by the PROGRESS project]]></title>
        <pubdate>2026-08-03T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Vera Belkin</author><author>Berit K. Labott</author><author>Claudia Voelcker-Rehage</author>
        <description><![CDATA[IntroductionNursing home residents show high sedentary behavior and limited physical functioning, while structural constraints hinder sustainable prevention. This study examined how group-based physical exercise and environmental interventions, such as activity-promoting materials and interior design, can be integrated into everyday care to promote a physical activity–promoting culture in nursing homes and identified key organizational and individual determinants of sustainable implementation.MethodsPROGRESS was a participatory, cluster-randomized cross-over trial conducted in seven nursing homes in the Münster area in Germany. Residents received two of four guided or non-guided exercise (n = 62) and/or environmental interventions (e.g., activity posters, a seated bike ergometer, walking brochures/routes; n = 65). Data from attendance logs, participatory workshops, and a follow-up questionnaire at t4 (the fourth and final measurement time point, approximately 50 weeks after baseline assessment; n = 73) were analyzed using descriptive statistics and structured content analysis for open-ended feedback. Based on these findings, the PROGRESS pyramid was developed as a framework for sustainable implementation of physical activity into everyday care.ResultsOf the 73 participants, 90.4% attended at least one guided intervention session. Participation was highest in the exercise intervention, with most residents reporting weekly engagement. In contrast, engagement with environmental interventions was more variable and strongly dependent on staff support, with 63.0% of residents reporting no independent use of physical activity opportunities. Comparisons between self-reported participation and attendance records revealed substantial discrepancies, particularly for environmental interventions. Overall satisfaction with the project was high (mean = 2.7 ± 2.5 on a 0 = happy to 10 = angry scale). Most participants supported continuation of the interventions (86.0%), and 64.0% reported perceived personal benefits. Organizational and individual determinants jointly shaped participation.ConclusionIn order to promote physical activity and functioning sustainably in nursing homes, it is necessary to address organizational conditions and individual needs in a coordinated manner. The PROGRESS pyramid translates these findings into a practical framework comprising organizational and communicational foundations, resident participation, education, and staff qualification to guide the long-term integration of exercise and environmental interventions into daily routine.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1842800</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1842800</link>
        <title><![CDATA[Comparison of anesthesia induction with ciprofol, propofol, and etomidate in elderly patients undergoing gastrointestinal endoscopy: a single center, prospective, double blind randomized controlled trial]]></title>
        <pubdate>2026-08-03T00:00:00Z</pubdate>
        <category>Clinical Trial</category>
        <author>Yingchao Guan</author><author>Gang Zhou</author><author>Conghui Wang</author><author>Yusong Lin</author><author>Minghong Ju</author><author>Wen He</author><author>Xiaodong Wang</author>
        <description><![CDATA[BackgroundWe compared benefits and adverse effects of anesthesia induction with ciprofol, propofol, and etomidate in elderly patients undergoing gastrointestinal endoscopy anesthesia.MethodsA total of 391 patients who underwent painless gastrointestinal endoscopy; age ≥ 60 years; ASA I-III were involved between April 30 and 30 December 2025. The primary outcome was hypoxemia or apnea during anesthesia. Secondary outcomes included systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP), heart rate (HR), respiratory rate (RR), SpO2 during surgery, and adverse reactions such as coughing dizziness and agitation.ResultsNo differences were found in hypoxemia and apnea. Except for RR, other hemodynamic and respiratory parameters were significantly different among the groups (p < 0.05), and the degree of blood pressure decline in group E was smaller than groups C and P. Group E patients had lower intraoperative hypotension (p = 0.007) and lower demand for vasoactive drugs (p = 0.006). The injection pain scores in groups C and E were lower, but patients in group E had a higher incidence of myoclonus, and the proportion of coughing and hiccups during endoscopy was higher in group E. The incidence of dizziness was lower in Group C.ConclusionNo significant differences were observed in the incidence of hypoxemia and apnea among three groups. Etomidate has the advantage of stable hemodynamics; however, the incidence of myoclonus, bucking, and hiccups is high. Injection pain occurred less frequently with ciprofol and etomidate, while ciprofol was associated with a low incidence of postoperative dizziness.Clinical Trail Registrationhttps://www.chictr.org.cn/showproj.html?proj=269837, identifier ChiCTR2500101280.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1872457</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1872457</link>
        <title><![CDATA[The impact of resistance training on the cognitive health of older adults: a narrative review]]></title>
        <pubdate>2026-07-30T00:00:00Z</pubdate>
        <category>Review</category>
        <author>Marie Pullerits</author><author>Ivi Vaher</author>
        <description><![CDATA[BackgroundPopulation aging is associated with an increased risk of cognitive decline, highlighting the need for effective and accessible interventions to support cognitive health in older adults. Resistance training has emerged as a promising non-pharmacological strategy; however, the role of training intensity in optimizing cognitive outcomes remains unclear.MethodsThis narrative review synthesizes 28 peer-reviewed publications, representing 24 independent study samples, published between 2014 and 2024 that examined the effects of resistance training intensity on cognitive function and related physiological markers in older adults.ResultsEvidence indicates that low-, moderate-, and high-intensity resistance training can improve cognitive performance and markers of overall brain and physiological health, including neurotrophic factors, inflammation, and cerebral blood flow. Reported benefits include improvements in executive function, memory, processing speed, and spatial abilities. Moderate-intensity resistance training (approximately 60%–79% of one-repetition maximum) showed the most consistent benefits across studies, though direct intensity comparisons remain limited.ConclusionsResistance training, particularly at moderate intensity, appears to be a feasible and effective strategy for supporting cognitive health in older adults, although further research is needed to determine optimal training prescriptions and long-term effects.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1868486</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1868486</link>
        <title><![CDATA[Advances in anti-aging Drug research leveraging multi-omics and artificial intelligence]]></title>
        <pubdate>2026-07-30T00:00:00Z</pubdate>
        <category>Review</category>
        <author>Lijuan Gao</author><author>Yongsheng Qin</author><author>Yudai Xu</author><author>Ju Su</author><author>Zhicheng Cai</author><author>Zhongyu Hu</author><author>Ruohu Shi</author><author>Xinyi Mu</author><author>Shiying Cen</author><author>Chanchan Xiao</author><author>Guobing Chen</author>
        <description><![CDATA[The intensifying global population aging has rendered the development of anti-aging drugs a core challenge in the life sciences domain. Traditional models struggle to address the systemic and networked nature of aging. Multi-omics technologies provide a panoramic perspective for deciphering molecular networks of aging, while Artificial Intelligence (AI) has demonstrated significant advantages in target discovery, drug screening, and clinical trial optimization. This review systematically elaborates on the pathological characteristics and molecular mechanisms of aging, analyzes the application paradigms of multi-omics in biomarker screening, mechanism elucidation, and high-throughput screening, and discusses the core value and technical bottlenecks of AI in target prediction, virtual screening, and trial design. Simultaneously, this paper addresses critical challenges including ethical controversies and data standardization currently confronting the field, and explores the prospects of precision anti-aging drug development and personalized treatment strategies driven by deep integration of multi-omics and AI. This approach offers novel theoretical frameworks and practical pathways for extending human healthspan.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1858726</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1858726</link>
        <title><![CDATA[Loneliness in older women: a multidimensional population-based study of social, health, and life-course factors]]></title>
        <pubdate>2026-07-29T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Esther Cabrera</author><author>Meritxell Puyané</author><author>Marc Terradellas</author><author>Esther Limón</author><author>Ester Mateo</author><author>Enric Camón</author><author>Carme Planas</author><author>Rosario Delgado</author><author>Chaimae Lamrani</author><author>Carolina Chabrera</author>
        <description><![CDATA[IntroductionLoneliness in older women is a major public health concern in ageing societies and a key determinant of healthy ageing. Despite its multidimensional nature, evidence on the relative contribution of social, health, and individual factors remains limited, particularly from a gender perspective.MethodsA cross-sectional population-based study was conducted in Catalonia using random sampling from the municipal census. Data were collected through face-to-face home interviews with 511 women. Loneliness was assessed with the 10-item Spanish version of the UCLA Loneliness Scale and analyzed as a binary outcome (moderate/severe vs. low or no loneliness). Explanatory variables were grouped into sociodemographic, social, clinical, functional, and quality-of-life domains. Crude and adjusted prevalence ratios were estimated using Poisson regression with robust variance.ResultsOverall, 18.6% of participants reported moderate or severe loneliness. In crude analyses, loneliness was more frequent among women living alone, with lower income, weaker community belonging, greater social vulnerability, depressive symptoms, frailty, poorer physical performance, higher fall risk, and lower quality-of-life scores. In the fully adjusted model, living alone remained associated with higher loneliness prevalence (adjusted prevalence ratio 1.99, 95% confidence interval 1.13–3.50). Depressive symptoms showed the strongest associations, with adjusted prevalence ratios of 3.59 (95% confidence interval 2.27–5.68) for mild symptoms and 5.37 (95% confidence interval 2.72–10.61) for moderate symptoms, while other domains were not independently associated.DiscussionThese findings suggest that emotional and social factors, particularly depressive symptoms and living alone, showed the strongest independent associations with loneliness among older women. These results provide evidence to inform the development of targeted and gender-sensitive strategies to prevent and address loneliness in later life.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1864923</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1864923</link>
        <title><![CDATA[Editorial: User-centered approaches for designing assistive technologies to support older adults]]></title>
        <pubdate>2026-07-28T00:00:00Z</pubdate>
        <category>Editorial</category>
        <author>Samuel Olatunji</author><author>Neziha Akalin</author><author>Xiaomei Liu</author><author>Renato Ferreira Leitão Azevedo</author>
        <description></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1880662</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1880662</link>
        <title><![CDATA[The Janus face of L-arginine supplementation in cardiovascular health and aging exploration of underlying mechanisms]]></title>
        <pubdate>2026-07-16T00:00:00Z</pubdate>
        <category>Review</category>
        <author>Zhihong Yang</author><author>Xiu-Fen Ming</author><author>Duilio M. Potenza</author>
        <description><![CDATA[Since the discovery of L-arginine-nitric oxide (NO) pathway in control of cardiovascular function in 1980s, endothelial dysfunction characterized by decreased endothelial NO bioavailability is recognized as a critical hallmark of cardiovascular disease (CVD) and aging, L-arginine supplementation has been proposed as a potential therapeutic intervention primarily due to its role as the sole substrate for endothelial NO-synthase (eNOS). Although many experimental and clinical studies show improvement of endothelial functions by L-arginine supplementation, the beneficial effects could not be translated into the improvement of hard endpoint outcome. Even harmful effects such as worsening of endothelial function, cardiac function, and increased mortality in patients with advanced CVD are reported in the randomized clinical trials. Despite of the reported adverse effects in clinical trials, L-arginine intake is considered safe and is still widely used in our society to boost muscle mass in healthy and aged populations. While we believe that chronic L-arginine supplementation shall be carefully implemented in clinical settings or shall be avoided in patients with advanced CVD and aged population, future studies shall focus on investigation of the underlying mechanisms of the adverse effects of L-arginine supplementation. This is important not only for L-arginine supplementation but also for other amino acid supplementation aimed to improve cardiovascular health, particularly in the elderly population.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1724246</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1724246</link>
        <title><![CDATA[Automated generation of personalized trajectories of aging phenotypes with DyViA-GAN]]></title>
        <pubdate>2026-07-15T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Saumyadipta Pyne</author><author>Deep Ray</author><author>Meghana Ray</author>
        <description><![CDATA[With a general increase in human lifespan, the need for technological advances to develop strategies for healthy aging has assumed great importance. In the present study, our goal is to predict the progression of selected aging phenotypes in a given healthy individual as they age past 65 years. Therefore, we developed a novel framework called dynamic views of aging with conditional generative adversarial networks (or DyViA-GAN) that can predict the plausible personalized trajectories of a selected aging phenotype conditioned on the available measurements of the phenotype at a few initial time instances and additional covariates. Given the prevalence of osteoporosis in the aging population, we selected the femoral neck bone mineral density (BMD) of a healthy individual as the phenotype of interest and baseline individual body mass index (BMI) as a covariate. We trained DyViA-GAN on a publicly available longitudinal dataset of a large cohort of mostly white women in the United States of age 65 years or above. It generated, for each individual, continuous phenotype trajectories, along with a corresponding region of acceptable predictions, for an age range of 66–89 years, for eight different combinations, both with and without involving the covariate. The prediction results were subjected to rigorous quality control and multiple comparative analyses. Our results clearly demonstrate the potential of generative deep learning frameworks in healthspan research.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1862298</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1862298</link>
        <title><![CDATA[Hip-hop dance participation and cognitive, gait, and muscle mass outcomes in community-dwelling older adults: a multi-site longitudinal study]]></title>
        <pubdate>2026-07-10T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Atsuko Miyazaki</author><author>Takashi Okuyama</author><author>Hayato Mori</author><author>Kazuhisa Sato</author><author>Sawako Ono</author><author>Atsushi Hiyama</author>
        <description><![CDATA[BackgroundDance-based interventions show promise for maintaining function in older adults, but long-term effects on body composition remain unclear. This study examined the effects of a hip-hop dance program on cognitive function, gait, and muscle mass over up to 3 years.MethodsThis multi-site longitudinal study included 102 community-dwelling older adults (mean age 74.2 years, 93% female) from six sites in Japan. The dance group (n = 74) participated in weekly hip-hop dance sessions and competed in the FIDA GOLD CUP, a competition for older adults. Controls (n = 28) maintained usual activities. Outcomes included cognitive function (MMSE, MoCA visuospatial), gait parameters, physical function, and body composition (SMI, segmental lean mass, BMI). Linear mixed models examined group × time interactions, and ANCOVA with permutation tests compared change scores in participants with complete data (n = 59).ResultsSignificant group × time interactions favoring the dance group were observed for MMSE (β = 0.58 points/year, p = 0.007) and MoCA visuospatial (β = 0.27/year, p = 0.023). Gait improved through temporal parameters: left contact time decreased (β = −0.018 s/year, p = 0.005) and gait speed increased (β = 0.065 m/s/year, p = 0.031), while stride length remained unchanged (p = 0.243). Right hip abduction strength (β = 1.22 kg/year, p = 0.016) and right single-leg stance time (β = 10.3 s/year, p = 0.026) improved. However, the dance group showed greater decline in skeletal muscle mass index (β = −0.064 kg/m2/year, p = 0.020) and leg segmental lean mass (left: β = −0.108 kg/year, p < 0.001; right: β = −0.088 kg/year, p = 0.004), while BMI remained unchanged (p = 0.949). ANCOVA confirmed these patterns for cognition, gait, and body composition outcomes.ConclusionHip-hop dance participation was associated with better preservation of cognitive function and more favorable gait-related change, characterized by enhanced temporal control rather than increased stride length. Specifically, reduced contact time and faster cadence suggest rhythm-based motor learning as the underlying mechanism. However, dance participation alone was not sufficient to prevent age-related muscle loss, indicating the need for combined interventions incorporating resistance training and adequate protein intake.]]></description>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1819415</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1819415</link>
        <title><![CDATA[Effects of a multicomponent exercise program on the gross and fine motor skills of healthy, sporting inactive older adults aged 60+]]></title>
        <pubdate>2026-07-03T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Anneke Schumacher</author><author>Marlene Krumpolt</author><author>Lucas Sannemann</author><author>Kerstin Witte</author>
        <description><![CDATA[This study aimed to assess the effectiveness of a multicomponent exercise program with integrated popular sports on the gross and fine motor coordination of healthy but sporting inactive adults aged 60 and above. Coordinative abilities are a key determinant of maintaining independence in later life. From February 2022 until December 2024 a 6-month pre-post intervention study with three measurement points: at baseline (t0), after 3 months (t1), and after completion of the intervention (t2) was conducted. The intervention groups started quarterly during the intervention period. In the intervention group (IG) a total of 161 older adults (68.23 ± 4.47 years; f = 107, m = 54) participated in a twice-weekly 90-min training program integrating popular sports. Gross motor skills were assessed using the Karlsruhe Health-Oriented Coordination Test (KHCT), and fine motor skills via the Motor Performance Series (MLS). Results were compared with an inactive control group (CGinactive: n = 32) and an active reference group of senior dancers (CGactive: n = 23), which was assessed cross-sectionally at baseline only. Compared to the CGinactive, the IG demonstrated significant improvements in six of the seven gross motor tasks and in two of the four fine motor tasks (group*time interaction: p < 0.05; Relative Treatment Effect = ΔRTE ≥0.12). Post-intervention, the IG’s performance approached that of the CGactive. The findings suggest that the low-threshold, multicomponent exercise program may improve coordinative abilities in previously inactive older adults. However, results should be interpreted with caution due to the non-randomized design and variability within the sample.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1791524</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1791524</link>
        <title><![CDATA[Impact of biopsychosocial frailty trends on survival and quality of life of older adults: a secondary analysis of data from a community-based active monitoring program]]></title>
        <pubdate>2026-06-26T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Giuseppe Liotta</author><author>Olga Madaro</author><author>Clara Donnoli</author><author>Fabio Riccardi</author><author>Giulia Picardo</author><author>Fausto Ciccacci</author><author>Michele Bisogno</author><author>Paola Scarcella</author>
        <description><![CDATA[BackgroundAdvancing age frequently brings about a complex condition known as biopsychosocial frailty, which significantly impacts an older adult’s survival and quality of life. This research investigates how changes in frailty levels affect mortality, hospitalization, and institutionalization, utilizing data from the “Long Live the Elderly!” program, a community-based initiative focused on proactive monitoring.MethodsA secondary analysis was conducted on data from 6,802 older adults participating in the LLE program across six Italian cities. Frailty was assessed using the Short Functional Geriatric Evaluation, which encompasses physical, psychological, and socio-economic dimensions. Trends in frailty were analyzed over an average follow-up period of 4.6 years, with survival outcomes evaluated using Cox proportional hazard models.ResultsAt baseline, 40.0% of participants were robust, 25.9% pre-frail, 27.4% frail, and 6.7% very frail. Frailty levels deteriorated in 36.9% of participants, while 11.2% experienced improvement. Higher frailty levels were significantly associated with increased mortality, hospitalization, and institutionalization. However, individuals whose frailty remained stable or improved showed significantly lower mortality rates compared to those whose frailty declined. Socio-economic enhancements were linked to better frailty outcomes, while psychophysical deterioration was the primary driver of declines.ConclusionFrailty is a dynamic condition that may improve or worsen over time. Stabilizing or improving frailty trajectories was associated with reduced mortality, hospitalization, and institutionalization, supporting the relevance of multidimensional frailty monitoring in community settings These findings can support the importance of proactive multidimensional frailty monitoring in aging populations.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1732426</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1732426</link>
        <title><![CDATA[A multi-modal longevity protocol integrating lifestyle, supplements, and autologous pro-regenerative cell-conditioned media: a pilot study]]></title>
        <pubdate>2026-06-25T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Esteban Ortega</author><author>Guenole Addor</author><author>Sonam Bhatia</author><author>Max Lewinsohn</author><author>Pierre-Edouard Sottas</author>
        <description><![CDATA[IntroductionBiological aging is a modifiable process contributing to functional decline and chronic disease risk. Multi-modal interventions targeting aging hallmarks have shown promise, yet human data integrating lifestyle, supplementation, and regenerative therapies remain limited.MethodsThis single-arm, open-label pilot trial in 16 healthy adults aged 46-72 (14 completers) tested a 17-week multi-modal program integrating lifestyle optimization, targeted supplementation, and two intravenous infusions of autologous pro-regenerative cell-derived conditioned media (APRC-CM). Trial registration: ClinicalTrials.gov, NCT07322224.ResultsThe intervention improved clinical biomarkers and reduced biological-age measures (PhenoAge and an epigenetic DNA-methylation clock) despite the cohort’s already healthy baseline (chronological age 59.3 years; PhenoAge 55.5 years; epigenetic age 57.9 years), consistent with a net reversal of biological age rather than merely a correction of age acceleration. PhenoAge declined by 2.0 years (p = 0.014), reaching 5.8 years below chronological age; epigenetic age decreased by 2.7 years (p = 0.003), widening the gap to 4.1 years. Exploratory response analysis revealed heterogeneity, with a larger-response subgroup showing a mean epigenetic-age reduction of 5.1 years versus 0.2 years in a smaller/no-response subgroup. Among baseline biomarkers, serum iron strongly predicted response: lower iron correlated with greater epigenetic-age reduction (r = 0.64; p = 0.013), identifying baseline iron status as a candidate prognostic biomarker of response. No adverse events were reported.DiscussionSuch reductions in health-optimized individuals are notable and may indicate a lowering below expected norms rather than solely a correction of age acceleration. The observed response heterogeneity, together with baseline iron metabolism as a potential predictor of response, is hypothesis-generating and warrants validation in larger, controlled trials, particularly as this open-label, single-arm pilot lacked a control or sham comparator.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1763012</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1763012</link>
        <title><![CDATA[Development of the social frailty scale for older adults under pandemic-related social restrictions]]></title>
        <pubdate>2026-06-24T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Pei-Hsin Fang</author><author>Ray-E. Chang</author><author>Robert C. Myrtle</author><author>Ying-Hui Hou</author><author>Ya-Mei Chen</author>
        <description><![CDATA[IntroductionSocial frailty, a key dimension of the multidimensional assessment of frailty, has been linked to poor health outcomes and poorer quality of life in older adults. However, definitions and measurements of social frailty vary and most do not provide assessments of reliability or validity. This study sought to identify the core components associated with social frailty and to create a reliable, valid social frailty scale.MethodsThis study adopts a psychometric approach to develop a social frailty scale for use in a community context under pandemic-related social restrictions. Systematic searching, content analysis, and a modified Delphi method were applied to develop a draft of a social frailty scale. Item-analysis, explorative factor analysis, confirmatory factor analysis, and reliability analysis were used to test scale properties. The subjects were older adults above 65 years old who live in Taiwan, and 446 people in total were interviewed to collect data.ResultsThe results indicated that five factors (two types of social support, social participation, social networks, and loneliness) and 16 items formed a social frailty scale with appropriate reliability and validity. This study advances our understanding of core components of social frailty.DiscussionThe social frailty scale integrates several social frailty instruments to detect social frailty in community context.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fragi.2026.1822471</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fragi.2026.1822471</link>
        <title><![CDATA[The impact of the six pillars of lifestyle medicine on the biology of skin aging]]></title>
        <pubdate>2026-06-17T00:00:00Z</pubdate>
        <category>Mini Review</category>
        <author>Jaime Piquero-Casals</author><author>Adriana R. Cruz</author><author>Lucas Ponti-Concetti</author><author>Ludmila Prudkin</author><author>Anthony Brown</author><author>Mónica Foyaca</author><author>Eduardo Rozas-Muñoz</author><author>Juan Francisco Mir-Bonafé</author><author>Daniel Morgado-Carrasco</author><author>Thierry Passeron</author>
        <description><![CDATA[Skin aging arises from the interaction between intrinsic genetic programs and cumulative environmental and behavioral exposures collectively defined as the exposome. Increasing evidence indicates that core molecular pathways driving skin aging, including mitochondrial dysfunction, oxidative stress, chronic inflammation, cellular senescence, and extracellular matrix remodeling are responsive to modifiable lifestyle factors. This narrative review examines the mechanistic and translational evidence linking the six pillars of Lifestyle Medicine; nutrition, physical activity, stress regulation, sleep, avoidance of toxic exposures, and social connection, to fundamental biological processes involved in skin aging. Across experimental models and human studies, these lifestyle domains converge on established hallmarks of aging, modulating redox balance, inflammatory signaling, mitochondrial biogenesis, epigenetic regulation, DNA repair, and dermal matrix integrity. Nutritional patterns influence glycation and oxidative stress; physical activity enhances mitochondrial and vascular function; chronic stress and sleep disruption amplify neuroendocrine and inflammatory pathways; toxic exposures activate matrix-degrading and senescence-associated cascades; and social isolation is associated with heightened systemic inflammatory tone. Collectively, these findings support the concept that skin aging represents a biologically plastic process shaped in part by lifestyle-dependent modulation of conserved aging mechanisms. Integrating lifestyle-responsive pathways into skin aging research may enable more targeted, preventive, and mechanism-based strategies in dermatological practice.]]></description>
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