AUTHOR=Zakzuk Josefina , Lozano Ana , Caraballo Luis TITLE=Allergological Importance of Invertebrate Glutathione Transferases in Tropical Environments JOURNAL=Frontiers in Allergy VOLUME=Volume 2 - 2021 YEAR=2021 URL=https://www.frontiersin.org/journals/allergy/articles/10.3389/falgy.2021.695262 DOI=10.3389/falgy.2021.695262 ISSN=2673-6101 ABSTRACT=

Glutathione-S transferases (GSTs) are part of a ubiquitous family of dimeric proteins that participate in detoxification reactions. It has been demonstrated that various GSTs induce allergic reactions in humans: those originating from house dust mites (HDM), cockroaches, and helminths being the best characterized. Evaluation of their allergenic activity suggests that they have a clinical impact. GST allergens belong to different classes: mu (Blo t 8, Der p 8, Der f 8, and Tyr p 8), sigma (Bla g 5 and Asc s 13), or delta (Per a 5). Also, IgE-binding molecules belonging to the pi-class have been discovered in helminths, but they are not officially recognized as allergens. In this review, we describe some aspects of the biology of GST, analyze their allergenic activity, and explore the structural aspects and clinical impact of their cross-reactivity.