AUTHOR=Grafeneder Juergen , Ettl Florian , Warenits Alexandra-Maria , Buchtele Nina , Lobmeyr Elisabeth , Staudinger Thomas , Schwameis Michael , Sperr Wolfgang R. , Gelbenegger Georg , Schoergenhofer Christian , Jilma Bernd 

TITLE=Multi-phasic life-threatening anaphylaxis refractory to epinephrine managed by extracorporeal membrane oxygenation (ECMO): A case report

JOURNAL=Frontiers in Allergy

VOLUME=Volume 3 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/allergy/articles/10.3389/falgy.2022.934436

DOI=10.3389/falgy.2022.934436

ISSN=2673-6101

ABSTRACT=We present the case of a 52-year-old patient suffering from multi-phasic life-threatening anaphylaxis refractory to epinephrine treatment. ECMO therapy was initiated as the ultima ratio to stabilize the patient hemodynamically and during severe bronchospasms. ECMO treatment was successfully weaned after 4 days. Mastocytosis was diagnosed as the underlying condition. Although epinephrine is recommended as first-line treatment for anaphylaxis, this impressive case provides clear evidence of its limited therapeutic success and emphasizes the need for causal therapies.