AUTHOR=Boateng Eistine , Kovacevic Draginja , Oldenburg Vladimira , Rådinger Madeleine , Krauss-Etschmann Susanne 

TITLE=Role of airway epithelial cell miRNAs in asthma

JOURNAL=Frontiers in Allergy

VOLUME=Volume 3 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/allergy/articles/10.3389/falgy.2022.962693

DOI=10.3389/falgy.2022.962693

ISSN=2673-6101

ABSTRACT=The airway epithelial cells and overlying layer of mucus are the first point of contact of particles entering the lung. Environmental contributions to pulmonary disease initiation, progression, and exacerbation are reliant on the engagement of the airway epithelium and accompanying immune cells. In spite of the cellular cross-talk and cargo exchange in the microenvironment, epithelial and immune cells produce miRNAs associated with the regulation of airway features. In line with this, there is cogent evidence indicating alterations in miRNA and their multifunctional regulation of asthma phenotypes in the conducting airways. In this review, we discussed the cellular components and functions of the airway epithelium in asthma, miRNAs particularly derived from epithelial and immune cells in the disease, the regulation of targets and local modulation of characteristic asthma phenotypes, and the cellular exchange of miRNA-bearing cargo in the airways.