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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Allergy</journal-id>
<journal-title>Frontiers in Allergy</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Allergy</abbrev-journal-title>
<issn pub-type="epub">2673-6101</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/falgy.2024.1395807</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Allergy</subject>
<subj-group>
<subject>Case Report</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>New-onset egg allergy in an adult: A case report</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes"><name><surname>Fujiwara</surname><given-names>Michimasa</given-names></name>
<xref ref-type="corresp" rid="cor1">&#x002A;</xref><uri xlink:href="https://loop.frontiersin.org/people/2659407/overview"/>
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<contrib contrib-type="author"><name><surname>Kimura</surname><given-names>Takashi</given-names></name>
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<contrib contrib-type="author"><name><surname>Ohira</surname><given-names>Junya</given-names></name>
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<contrib contrib-type="author"><name><surname>Inotani</surname><given-names>Motohiro</given-names></name>
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<contrib contrib-type="author"><name><surname>Sakane</surname><given-names>Tomoko</given-names></name>
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<contrib contrib-type="author"><name><surname>Iwase</surname><given-names>Mizue</given-names></name>
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<contrib contrib-type="author"><name><surname>Yamashita</surname><given-names>Sadanori</given-names></name>
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<contrib contrib-type="author"><name><surname>Araki</surname><given-names>Tooru</given-names></name>
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<aff><institution>Department of Pediatrics, NHO Fukuyama Medical Center</institution>, <addr-line>Fukuyama</addr-line>, <country>Japan</country></aff>
<author-notes>
<fn fn-type="edited-by"><p><bold>Edited by:</bold> Lucie Mondoulet, Independent Researcher, Kremlin Bic&#x00EA;tre, France</p></fn>
<fn fn-type="edited-by"><p><bold>Reviewed by:</bold> Venugopal Gangur, Michigan State University Museum, United States</p>
<p>Enrique Fernandez-Caldas, Inmunotek SL, Spain</p></fn>
<corresp id="cor1"><label>&#x002A;</label><bold>Correspondence:</bold> Michimasa Fujiwara <email>fujiwara.michimasa.kw@mail.hosp.go.jp</email></corresp>
</author-notes>
<pub-date pub-type="epub"><day>02</day><month>04</month><year>2024</year></pub-date>
<pub-date pub-type="collection"><year>2024</year></pub-date>
<volume>5</volume><elocation-id>1395807</elocation-id>
<history>
<date date-type="received"><day>04</day><month>03</month><year>2024</year></date>
<date date-type="accepted"><day>20</day><month>03</month><year>2024</year></date>
</history>
<permissions>
<copyright-statement>&#x00A9; 2024 Fujiwara, Kimura, Ohira, Inotani, Sakane, Iwase, Yamashita and Araki.</copyright-statement>
<copyright-year>2024</copyright-year><copyright-holder>Fujiwara, Kimura, Ohira, Inotani, Sakane, Iwase, Yamashita and Araki</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License (CC BY)</ext-link>. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p></license>
</permissions>
<abstract>
<p>Most adult cases of hen&#x0027;s egg allergy are carried over from childhood, and new-onset adult cases are rare. Such cases may result from cross-reactivity or sensitization by inhalation. Here we present a rare case of adult-onset egg allergy due to monosensitization to ovalbumin (Gal d 2) with an unclear sensitization pathway. A 27-year-old woman developed recurrent gastrointestinal symptoms after ingestion of raw and under-cooked eggs. She had never suffered from atopic dermatitis or food allergies. She had never kept birds as pets and had no history of exposure to egg allergens. Prick to prick testing was positive only with raw egg white. Specific IgE testing revealed monosensitization to Gal d 2. She was advised to avoid raw and undercooked eggs and her symptoms resolved. In the management of adult-onset egg allergy, evaluation of allergen components will lead to appropriate elimination guidelines, and investigation of sensitization pathways may help identify the cause of this disease.</p>
</abstract>
<kwd-group>
<kwd>adult-onset</kwd>
<kwd>case report</kwd>
<kwd>egg allergy</kwd>
<kwd>ovalbumin</kwd>
<kwd>Gal d 2</kwd>
</kwd-group>
<counts>
<fig-count count="0"/>
<table-count count="2"/><equation-count count="0"/><ref-count count="16"/><page-count count="0"/><word-count count="0"/></counts><custom-meta-wrap><custom-meta><meta-name>section-at-acceptance</meta-name><meta-value>Food Allergy</meta-value></custom-meta></custom-meta-wrap>
</article-meta>
</front>
<body>
<sec id="s1" sec-type="intro"><title>Introduction</title>
<p>Hen&#x0060;s eggs are one of the most common causes of food allergies. Egg allergy primarily affects infants and young children (<xref ref-type="bibr" rid="B1">1</xref>). Most patients outgrow egg allergy by adolescence (<xref ref-type="bibr" rid="B2">2</xref>). Egg allergies in adults are rare and most are carryover from childhood. New-onset egg allergy in adults is unusual and usually develops as the &#x201C;bird-egg syndrome&#x201D; caused by cross-reactivity between serum albumins present in bird feathers and yolk (<xref ref-type="bibr" rid="B3">3</xref>) or as the &#x201C;egg-egg syndrome&#x201D; caused by occupational sensitization in workers in the bakery and confectionary industries (<xref ref-type="bibr" rid="B4">4</xref>). Since there are few reports of new-onset adult egg allergy due to causes other than these entities, its pathogenesis is not well understood. Here, we report a rare adult case of new-onset egg allergy due to ovalbumin monosensitization with unknown pathogenesis.</p>
</sec>
<sec id="s2"><title>Case report</title>
<p>A 27-year-old woman who was a clinical resident at our institution had recurrent episodes of nausea, abdominal pain, and diarrhea within an hour of ingesting various foods containing raw or undercooked eggs. The symptoms resolved within a few hours and there were no skin, mucous membrane, or respiratory complications. No symptoms were observed with cooked eggs. She had been able to consume chicken eggs since childhood without restriction. She also did not report any allergic disease such as atopic dermatitis. She had no history of oral lysozyme-containing medications, ovalbumin-containing vaccinations, accidental ovalbumin exposure by ocular injection or splashing, laboratory work with egg proteins in experiments, or previous blood infusions from egg allergic subjects. She had never kept birds as pets. Blood tests revealed specific IgE antibody levels (Immuno CAP; Thermo Fisher Scientific, Waltham, MA, USA) of 3.43 U/ml (class 3), 0.34 U/ml (class 0), 0.02 U/ml (class 0), 0.05 U/ml (class 0), and 0.02 U/ml (class 0) for egg white, yolk, ovomucoid (Gal d 1), parrot feathers, and parrot dander, respectively.</p>
<p>In addition, a skin-prick test was performed on the volar side of the forearm using a bifurcated needle (ALO bifurcated needle; TMI, Tokyo, Japan). The positive (10&#x2005;mg/ml dihydrochloride histamine) and negative controls (0.9&#x0025; saline) were 10 and 0&#x2005;mm, respectively. A positive response was defined as wheal size equal to or greater than half the diameter of the positive control. Prick test with egg white extract yielded positive results (wheal diameter, 12&#x2005;mm), whereas yolk extract yielded negative results. Prick-to-prick tests with raw egg white yielded positive results (wheal diameter, 11&#x2005;mm), whereas boiled egg white and raw and boiled egg yolk yielded negative results (<xref ref-type="table" rid="T1">Table&#x00A0;1</xref>). Oral food challenge tests for both the whole hard-boiled yolk and egg white were negative, but the raw egg could not be administered because of lack of consent.</p>
<table-wrap id="T1" position="float"><label>Table 1</label>
<caption><p>Results of prick tests in a patient with suspected egg allergy.</p></caption>
<table frame="hsides" rules="groups">
<colgroup>
<col align="left"/>
<col align="center"/>
<col align="center"/>
</colgroup>
<thead>
<tr>
<th valign="top" align="left"/>
<th valign="top" align="center">Wheal, mm</th>
<th valign="top" align="center">Erythema, mm</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left" colspan="3">Control</td>
</tr>
<tr>
<td valign="top" align="left">Histamin (positive)</td>
<td valign="top" align="center">10</td>
<td valign="top" align="center">23</td>
</tr>
<tr>
<td valign="top" align="left">Saline (negative)</td>
<td valign="top" align="center">0</td>
<td valign="top" align="center">2</td>
</tr>
<tr>
<td valign="top" align="left" colspan="3">Commercial extracts</td>
</tr>
<tr>
<td valign="top" align="left">Egg white</td>
<td valign="top" align="center">12</td>
<td valign="top" align="center">22</td>
</tr>
<tr>
<td valign="top" align="left">Yolk</td>
<td valign="top" align="center">0</td>
<td valign="top" align="center">2</td>
</tr>
<tr>
<td valign="top" align="left" colspan="3">Prick-to-prick method</td>
</tr>
<tr>
<td valign="top" align="left">Raw egg white</td>
<td valign="top" align="center">11</td>
<td valign="top" align="center">20</td>
</tr>
<tr>
<td valign="top" align="left">Raw yolk</td>
<td valign="top" align="center">0</td>
<td valign="top" align="center">3</td>
</tr>
<tr>
<td valign="top" align="left">Cooked egg white</td>
<td valign="top" align="center">0</td>
<td valign="top" align="center">3</td>
</tr>
<tr>
<td valign="top" align="left">Cooked yolk</td>
<td valign="top" align="center">0</td>
<td valign="top" align="center">3</td>
</tr>
</tbody>
</table>
</table-wrap>
<p>The IgE assays for ovalbumin (Gal d 2), ovotransferrin (Gal d 3), and lysozyme (Gal d 4) were 4.62 U/ml (class 3), &#x003C;0.01 U/ml (class 0), and &#x003C;0.01 U/ml (class 0), respectively (obtained from Thermo Fisher Scientific).</p>
<p>Based on the clinical course and laboratory findings, we diagnosed the patient with adult-onset egg allergy. Since she was monosensitized to ovalbumin, we determined that the removal of well-cooked eggs was unnecessary. She reported no further episodes of immediate reactions since adhering to the avoidance of raw and undercooked eggs.</p>
</sec>
<sec id="s3" sec-type="discussion"><title>Discussion</title>
<p>Here, we report a rare case of adult-onset egg allergy due to ovalbumin monosensitization with an unclear sensitization pathway. Measurement of allergenic components revealed that the patient was monosensitized to Gal d 2. Therefore, the elimination of eggs was limited to raw and undercooked eggs, which led to a minimal decrease in the patient&#x0027;s quality of life.</p>
<p>Recent evidence suggests potential disparities in the phenotypic presentation of IgE-mediated food allergy between childhood and adulthood (<xref ref-type="bibr" rid="B5">5</xref>). While previous studies have examined the natural progression of food allergy during childhood (<xref ref-type="bibr" rid="B6">6</xref>), limited studies have been conducted to investigate how oral immune tolerance to previously consumed foods is disrupted during adulthood. Also in present case, we could not explain a reason that might explain the disruption of oral tolerance constituted in childhood.</p>
<p>Egg proteins have been identified in both egg white and yolk (<xref ref-type="bibr" rid="B7">7</xref>). The main allergenic components of egg white are Gal d 1, Gal d 2, Gal d 3, and Gal d 4. Gal d 1 is the most allergenic egg glycoprotein, followed by Gal d 2, 3, and 4 (<xref ref-type="bibr" rid="B8">8</xref>). As Gal d 1 is heat-stable and Gal d 2 is heat-labile, most patients with monosensitization to Gal d 2 tolerate heated egg (<xref ref-type="bibr" rid="B9">9</xref>). In addition, IgE sensitization to Gal d 2 in the absence of IgE to Gal d 1 is considered a predictor of specific reactivity to raw egg (<xref ref-type="bibr" rid="B10">10</xref>). Our patient was monosensitized to Gal d 2 and tolerated heated eggs; therefore, we instructed to remove only raw and undercooked eggs. In adult-onset egg allergies, evaluation of allergen components, as in the present case, may lead to minimal food elimination.</p>
<p>Most reported cases of adult-onset egg allergy are caused by sensitization due to cross-reactivity or a clear pathway of sensitization. The bird-egg syndrome primarily manifests as respiratory symptoms upon exposure to birds and secondarily as allergic symptoms following the ingestion of eggs. This syndrome involves cross-sensitization to both yolk and various bird allergens, including feathers and droppings (<xref ref-type="bibr" rid="B3">3</xref>). This phenomenon underscores the cross-reactivity and sensitization via inhalation through the respiratory pathway. The egg-egg syndrome primarily manifests as respiratory symptoms upon exposure to egg aerosols in the bakery and confectionery industries and secondarily as allergic symptoms following the ingestion of eggs (<xref ref-type="bibr" rid="B4">4</xref>). This phenomenon also underscores sensitization through the respiratory pathway. In addition, adult-onset egg allergies due to transdermal sensitization via hand eczema (<xref ref-type="bibr" rid="B11">11</xref>) or due to sensitization to lysozymes caused by the oral administration of pharmaceutical preparations containing lysozyme have been reported (<xref ref-type="bibr" rid="B12">12</xref>). The present case did not fall into any of these categories. The history of exposure and the route of sensitization to Gal d 2 were not clarified in the detailed interviews.</p>
<p>In English literature, only four cases of new-onset egg allergy in adults with an unclear sensitization pathway have been reported so far (<xref ref-type="bibr" rid="B13">13</xref>&#x2013;<xref ref-type="bibr" rid="B16">16</xref>). A review of these five cases, including the present case, is presented in <xref ref-type="table" rid="T2">Table&#x00A0;2</xref>. The ages were between 27 and 57 years, and there were four females and one male. In three of the five cases, the egg properties that induced allergic symptoms were limited to raw or undercooked eggs. Allergic symptoms varied from case to case, with two of the five cases presenting with anaphylaxis. Case 1 presented with symptoms localized to the mucosa and gastrointestinal tract. In addition, Case 4 and the present case presented with symptoms with localized gastrointestinal tract, suggesting the possibility of food protein-induced gastroenteritis syndrome. However, the results of specific IgE antibody and skin prick test were suggestive of IgE-mediated food allergy. The pattern of sensitization to eggs also differed from case to case, but Case 4 and the present case shared monosensitization to Gal d 2, and symptoms were induced only by raw or undercooked eggs in both cases. The cause of unusual clinical symptoms limited to gastrointestinal or mucosal symptoms lacking systemic reaction was considered to depend on sensitivity to enzymatic digestion (<xref ref-type="bibr" rid="B13">13</xref>) and the presence of intact gastrointestinal mucosa (<xref ref-type="bibr" rid="B16">16</xref>). In these cases, the pathogenesis of adult-onset egg allergy was unclear, with the possibility of stress noted only in Case 2. Prognosis was unclear in all cases. Because there is a lack of information on the pathogenesis and prognosis of adult-onset egg allergies, in which a clear pathway of sensitization cannot be identified, further case series are desirable.</p>
<table-wrap id="T2" position="float"><label>Table 2</label>
<caption><p>The review of adult onset egg allergy with an unknown pathogenesis.</p></caption>
<table frame="hsides" rules="groups">
<colgroup>
<col align="left"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
</colgroup>
<thead>
<tr>
<th valign="top" align="left">Case</th>
<th valign="top" align="center">1</th>
<th valign="top" align="center">2</th>
<th valign="top" align="center">3</th>
<th valign="top" align="center">4</th>
<th valign="top" align="center">5</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Age at onset</td>
<td valign="top" align="center">47</td>
<td valign="top" align="center">55</td>
<td valign="top" align="center">50</td>
<td valign="top" align="center">30</td>
<td valign="top" align="center">27</td>
</tr>
<tr>
<td valign="top" align="left">Sex</td>
<td valign="top" align="center">Female</td>
<td valign="top" align="center">Female</td>
<td valign="top" align="center">Female</td>
<td valign="top" align="center">Male</td>
<td valign="top" align="center">Female</td>
</tr>
<tr>
<td valign="top" align="left">Egg properties that induce symptoms</td>
<td valign="top" align="center">Raw or undercooked eggs</td>
<td valign="top" align="center">Egg or egg-containing products</td>
<td valign="top" align="center">Egg or egg-containing products</td>
<td valign="top" align="center">Raw or undercooked eggs</td>
<td valign="top" align="center">Raw or undercooked eggs</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="3">Allergic symptoms</td>
<td valign="top" align="center">Mucosal</td>
<td valign="top" align="center">Mucosal</td>
<td valign="top" align="center">Mucosal</td>
<td valign="top" align="center" rowspan="3">Gastrointestinal</td>
<td valign="top" align="center" rowspan="3">Gastrointestinal</td>
</tr>
<tr>
<td valign="top" align="center">Gastrointestinal</td>
<td valign="top" align="center">Respiratory</td>
<td valign="top" align="center">Skin</td>
</tr>
<tr>
<td valign="top" align="left"/>
<td valign="top" align="center"/>
<td valign="top" align="center">Respiratory</td>
</tr>
<tr>
<td valign="top" align="left">Anaphylaxis</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x002B;</td>
<td valign="top" align="center">&#x002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
</tr>
<tr>
<td valign="top" align="left" colspan="6">Specific IgE</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;EW (UA/ml)</td>
<td valign="top" align="center">N.D.</td>
<td valign="top" align="center">2.8</td>
<td valign="top" align="center">1.22</td>
<td valign="top" align="center">3.52</td>
<td valign="top" align="center">3.43</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Yolk (UA/ml)</td>
<td valign="top" align="center">N.D.</td>
<td valign="top" align="center">Negative</td>
<td valign="top" align="center">0.44</td>
<td valign="top" align="center">N.D.</td>
<td valign="top" align="center">1.58</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Ovomucoid (UA/ml)</td>
<td valign="top" align="center">N.D.</td>
<td valign="top" align="center">N.D.</td>
<td valign="top" align="center">N.D.</td>
<td valign="top" align="center">0.10</td>
<td valign="top" align="center">0.02</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Ovalbumin (UA/ml)</td>
<td valign="top" align="center">N.D.</td>
<td valign="top" align="center">N.D.</td>
<td valign="top" align="center">N.D.</td>
<td valign="top" align="center">8.87</td>
<td valign="top" align="center">4.62</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="3">Skin prick test</td>
<td valign="top" align="center">EW (3&#x002B;)</td>
<td valign="top" align="center">EW (&#x002B;)</td>
<td valign="top" align="center">EW (&#x002B;)</td>
<td valign="top" align="center" rowspan="4">N.D.</td>
<td valign="top" align="center">EW (&#x002B;)</td>
</tr>
<tr>
<td valign="top" align="center">Yolk (3&#x002B;)</td>
<td valign="top" align="center">Yolk (&#x002B;)</td>
<td valign="top" align="center">Yolk (&#x002B;)</td>
<td valign="top" align="center">Yolk (&#x2212;)</td>
</tr>
<tr>
<td valign="top" align="left"/>
<td valign="top" align="center">WE (&#x002B;)</td>
<td valign="top" align="center">WE (&#x002B;)</td>
<td valign="top" align="center"/>
</tr>
<tr>
<td valign="top" align="left" rowspan="4">Prick-to-prick test</td>
<td valign="top" align="center" rowspan="4">N.D.</td>
<td valign="top" align="center"/>
<td valign="top" align="center" rowspan="4">N.D.</td>
<td valign="top" align="center">Raw EW (&#x002B;)</td>
</tr>
<tr>
<td valign="top" align="center">Boiled EW (&#x002B;)</td>
<td valign="top" align="center">Raw EW (&#x002B;)</td>
<td valign="top" align="center">Raw Yolk (&#x2212;)</td>
</tr>
<tr>
<td valign="top" align="center">Boiled Yolk (&#x2212;)</td>
<td valign="top" align="center">Boiled EW (&#x002B;)</td>
<td valign="top" align="center">Boiled EW (&#x2212;)</td>
</tr>
<tr>
<td valign="top" align="left"/>
<td valign="top" align="center"/>
<td valign="top" align="center">Boiled Yolk (&#x2212;)</td>
</tr>
<tr>
<td valign="top" align="left">Pathogenesis</td>
<td valign="top" align="center">Unclear</td>
<td valign="top" align="center">Stress</td>
<td valign="top" align="center">Unclear</td>
<td valign="top" align="center">Unclear</td>
<td valign="top" align="center">Unclear</td>
</tr>
<tr>
<td valign="top" align="left">Reference</td>
<td valign="top" align="center">(11)</td>
<td valign="top" align="center">(12)</td>
<td valign="top" align="center">(13)</td>
<td valign="top" align="center">(14)</td>
<td valign="top" align="center">Present case</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="table-fn1"><p>EW, egg white; WE, whole egg; N.D., not described.</p></fn>
</table-wrap-foot>
</table-wrap>
<p>In conclusion, when managing adult-onset egg allergy, evaluation of allergen components will lead to appropriate removal guidance, and investigation of sensitization pathways may help identify the cause of this disease.</p>
</sec>
</body>
<back>
<sec id="s4" sec-type="data-availability"><title>Data availability statement</title>
<p>The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author.</p>
</sec>
<sec id="s5" sec-type="ethics-statement"><title>Ethics statement</title>
<p>The studies involving humans were approved by The ethics committee of NHO Fukuyama Medical Center. The studies were conducted in accordance with the local legislation and institutional requirements. The participants provided their written informed consent to participate in this study. Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article.</p>
</sec>
<sec id="s6" sec-type="author-contributions"><title>Author contributions</title>
<p>MF: Conceptualization, Data curation, Formal Analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing &#x2013; original draft, Writing &#x2013; review &#x0026; editing. TK: Supervision, Writing &#x2013; review &#x0026; editing. JO: Supervision, Writing &#x2013; review &#x0026; editing. MI: Supervision, Writing &#x2013; review &#x0026; editing. TS: Supervision, Writing &#x2013; review &#x0026; editing. MI: Supervision, Writing &#x2013; review &#x0026; editing. SY: Supervision, Writing &#x2013; review &#x0026; editing. TA: Supervision, Validation, Visualization, Writing &#x2013; review &#x0026; editing.</p>
</sec>
<sec id="s7" sec-type="funding-information"><title>Funding</title>
<p>The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.</p>
</sec>
<sec id="s8" sec-type="COI-statement"><title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec id="s9" sec-type="disclaimer"><title>Publisher&#x0027;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
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