AUTHOR=Su Bin Brenda , Blackmon Warren , Xu Chun , Holt Christopher , Boateng Nathaniel , Wang Darren , Szafron Vibha , Anagnostou Aikaterini , Anvari Sara , Davis Carla M. TITLE=Diagnosis and management of shrimp allergy JOURNAL=Frontiers in Allergy VOLUME=Volume 5 - 2024 YEAR=2024 URL=https://www.frontiersin.org/journals/allergy/articles/10.3389/falgy.2024.1456999 DOI=10.3389/falgy.2024.1456999 ISSN=2673-6101 ABSTRACT=Shrimp allergy, the most common food allergy in the United States, affects up to 2% of the population. Its etiology is multi-factorial with the combination of genetic predisposition and environmental exposures. This review summarizes the latest diagnosis and management strategies for shrimp allergy. Currently, the double-blind, placebo-controlled food challenge is the gold standard for diagnosis. Moreover, mainstream and experimental management strategies include food allergen avoidance, the FDA-approved omalizumab, and oral immunotherapy. Herein, we emphasize the urgent need to develop more effective diagnostic tools and therapies for shrimp allergy.