AUTHOR=Pereira De Oliveira Rémi , Droillard Clément , Devouassoux Gilles , Rosa-Calatrava Manuel 

TITLE=In vitro models to study viral-induced asthma exacerbation: a short review for a key issue

JOURNAL=Frontiers in Allergy

VOLUME=Volume 6 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/allergy/articles/10.3389/falgy.2025.1530122

DOI=10.3389/falgy.2025.1530122

ISSN=2673-6101

ABSTRACT=Asthma is a heterogenous inflammatory bronchial disease involving complex mechanisms, several inflammatory pathways, and multiples cell-type networks. Bronchial inflammation associated to asthma is consecutive to multiple aggressions on epithelium, such as microbiologic, pollutant, and antigenic agents, which are responsible for both T2 and non-T2 inflammatory responses and further airway remodeling. Because asthma physiopathology involves multiple crosstalk between several cell types from different origins (epithelial, mesenchymal, and immune cells) and numerous cellular effectors, no single and/or representative in vitro model is suitable to study the overall of this disease. In this short review, we present and discuss the advantages and limitations of different in vitro models to decipher different aspects of virus-related asthma physiopathology and exacerbation.