AUTHOR=Khalid Nauman , Akbar Zunaira , Mustafa Nosheen , Akbar Jamshaid , Saeed Shanawar , Saleem Zikria 

TITLE=Trends in antimicrobial susceptibility patterns of bacterial isolates in Lahore, Pakistan

JOURNAL=Frontiers in Antibiotics

VOLUME=Volume 2 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/antibiotics/articles/10.3389/frabi.2023.1149408

DOI=10.3389/frabi.2023.1149408

ISSN=2813-2467

ABSTRACT=Abstract
Background
Antimicrobial resistance (AMR) has provoked as a global health issue. Antimicrobial stewardship programs should be executed to overcome this issue. The aim of this study was to determine the sensitivity pattern of WHO Aware group antibiotics that assists in selection of appropriate empiric antibiotic therapy.
Method
A descriptive, cross sectional study was conducted for 6 month duration in which 422 culture sensitivity sample reports from hospital's laboratory were obtained through convenient sampling technique and sensitivity pattern of 9 offending bacteria to the WHO Aware group antibiotics were determined. Descriptive statistics and differences in frequency distribution among the categorical variables were performed using SPSS version 21.
Results
Among 422 culture sensitivity sample reports, E.coli (16.1%) was the most common gram-negative pathogen. Acinetobacter, E.coli, Klebsiella, Pseudomonas showed 100% sensitivity to polymyxin-b and colistin. Proteus showed highest sensitivity to meropenem (90%), Staph. aureus showed 98% sensitivity to linezolid, Staph.epidermidis was 100% sensitive to vancomycin and linezolid whereas Streptococcus showed highest sensitivity to penicillin (100%) and vancomycin (94.7%). Polymyxin b and colistin were found to be most effective antibiotics against gram-negative bacteria (100%). Gram-positive bacteria were highly susceptible to linezolid (99.4%), vancomycin (98.2%), chloramphenicol (89.5%) and tigecycline (82.6%).