AUTHOR=Rao Harshavardhan B. , Sastry Nandakumar Bidare , Venu Rama P. , Pattanayak Preetiparna TITLE=The role of artificial intelligence based systems for cost optimization in colorectal cancer prevention programs JOURNAL=Frontiers in Artificial Intelligence VOLUME=Volume 5 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/artificial-intelligence/articles/10.3389/frai.2022.955399 DOI=10.3389/frai.2022.955399 ISSN=2624-8212 ABSTRACT=Colorectal Cancer (CRC) has seen a dramatic increase in incidence globally. In 2019, colorectal cancer accounted for 1.15 million deaths and 24.28 million disability-adjusted life-years (DALYs) worldwide. In India, the annual incidence rates (AARs) for colon cancer was 4.4 per 100000. There has been a steady rise in the prevalence of CRC in India which may be attributed to urbanization, mass migration of population, westernization of diet and lifestyle practices and a rise of obesity and metabolic risk factors that place the population at a higher risk of CRC. Early identification of adenomatous colonic polyps, which are well-recognized pre-cancerous lesions, at the time of screening colonoscopy has been shown to be the most effective measure used for CRC prevention. However, colonic polyps are frequently missed during colonoscopy and moreover, these screening programs necessitate man-power, time and resources for processing resected polyps, that may hamper penetration and efficacy in mid- to low-income countries. In the last decade, there has been significant progress made in the automatic detection of colonic polyps by multiple AI-based systems. With the advent of better AI methodology, the focus has shifted from mere detection to accurate discrimination and diagnosis of colonic polyps. These systems, once validated, could usher in a new era in Colorectal Cancer(CRC) prevention pwhich could have signficant implications on cost-effectiveness and healthcare expenditure. The adoption of these AI-based systems in the national cancer prevention program of India in accordance with the mandate to increase technology integration could have a profound impact on CRC prevention at the population level. In this review, we will highlight key advancements made in the field of AI in the identification of polyps during colonoscopy and explore the role of AI based systems in cost optimization during the universal implementation of CRC prevention programs in the context of mid-income countries like India.