AUTHOR=Binzagr Faisal , Abulfaraj Anas W. 

TITLE=InGSA: integrating generalized self-attention in CNN for Alzheimer's disease classification

JOURNAL=Frontiers in Artificial Intelligence

VOLUME=Volume 8 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/artificial-intelligence/articles/10.3389/frai.2025.1540646

DOI=10.3389/frai.2025.1540646

ISSN=2624-8212

ABSTRACT=Alzheimer's disease (AD) is an incurable neurodegenerative disorder that slowly impair the mental abilities. Early diagnosis, nevertheless, can greatly reduce the symptoms that are associated with the condition. Earlier techniques of diagnosing the AD from the MRI scans have been adopted by traditional machine learning technologies. However, such traditional methods involve depending on feature extraction that is usually complex, time-consuming, and requiring substantial effort from the medical personnel. Furthermore, these methods are usually not very specific as far as diagnosis is concerned. In general, traditional convolutional neural network (CNN) architectures have a problem with identifying AD. To this end, the developed framework consists of a new contrast enhancement approach, named haze-reduced local-global (HRLG). For multiclass AD classification, we introduce a global CNN-transformer model InGSA. The proposed InGSA is based on the InceptionV3 model which is pre-trained, and it encompasses an additional generalized self-attention (GSA) block at top of the network. This GSA module is capable of capturing the interaction not only in terms of the spatial relations within the feature space but also over the channel dimension it is capable of picking up fine detailing of the AD information while suppressing the noise. Furthermore, several GSA heads are used to exploit other dependency structures of global features as well. Our evaluation of InGSA on a two benchmark dataset, using various pre-trained networks, demonstrates the GSA's superior performance.