AUTHOR=Elmotelb A. S. , Sherif Fayroz F. , Abohamama A. S. , Fakhr Mahmoud , Abdelatif Amr M. TITLE=A novel deep learning technique for multi classify Alzheimer disease: hyperparameter optimization technique JOURNAL=Frontiers in Artificial Intelligence VOLUME=Volume 8 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/artificial-intelligence/articles/10.3389/frai.2025.1558725 DOI=10.3389/frai.2025.1558725 ISSN=2624-8212 ABSTRACT=A progressive brain disease that affects memory and cognitive function is Alzheimer’s disease (AD). To put therapies in place that potentially slow the progression of AD, early diagnosis and detection are essential. Early detection of these phases enables early activities, which are essential for controlling the disease. To address issues with limited data and computing resources, this work presents a novel deep-learning method based on using a newly proposed hyperparameter optimization method to identify the hyperparameters of ResNet152V2 model for classifying the phases of AD more accurately. The proposed model is compared to state-of-the-art models divided into two categories: transfer learning models and classical models to showcase its effectiveness and efficiency. This comparison is based on four performance metrics: recall, precision, F1 score, and accuracy. According to the experimental results, the proposed method is more efficient and effective in classifying various AD phases.