AUTHOR=Sowmya V. L. , Bharathi Malakreddy A. , Natarajan Santhi , Prathik N. , Rajesh I. S. 

TITLE=Spectral Entropic Radiomics Feature Extraction (SERFE): an adaptive approach for glioblastoma disease classification

JOURNAL=Frontiers in Artificial Intelligence

VOLUME=Volume 8 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/artificial-intelligence/articles/10.3389/frai.2025.1583079

DOI=10.3389/frai.2025.1583079

ISSN=2624-8212

ABSTRACT=IntroductionRadiomics-based glioblastoma classification demands feature extraction techniques that can effectively capture tumor heterogeneity while maintaining computational efficiency. Conventional tools such as PyRadiomics and CaPTk rely on extensive handcrafted feature sets, which often result in redundancy and necessitate further optimization steps.MethodsThis study proposes a novel framework, Spectral Entropic Radiomics Feature Extraction (SERFE), which integrates spectral frequency decomposition, entropy-driven feature selection, and graph-based spatial encoding. SERFE decomposes voxel intensity fluctuations into spectral signatures, employs entropy-based weighting to prioritize informative features, and preserves spatial topology through graph-based modeling. The method was evaluated using the public TCIA glioblastoma dataset.ResultsSERFE generated a refined feature set of 350 radiomic features from an initial pool of 2,260, achieving a 92% stability score and 91.7% classification accuracy. This performance surpasses traditional radiomics methods in both predictive accuracy and feature compactness.DiscussionThe results demonstrate SERFE’s capacity to enhance tumor characterization and streamline radiomics pipelines without requiring post-extraction feature reduction. Its compatibility with existing clinical workflows makes it a promising tool for future neuro-oncology applications.