AUTHOR=Gao Yifan , Mughal Zakariyya , Jaramillo-Villegas Jose A. , Corradi Marie , Borrel Alexandre , Lieberman Ben , Sharif Suliman , Shaffer John , Fecho Karamarie , Chatrath Ajay , Maertens Alexandra , Teunis Marc A. T. , Kleinstreuer Nicole , Hartung Thomas , Luechtefeld Thomas TITLE=BioBricks.ai: a versioned data registry for life sciences data assets JOURNAL=Frontiers in Artificial Intelligence VOLUME=Volume 8 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/artificial-intelligence/articles/10.3389/frai.2025.1599412 DOI=10.3389/frai.2025.1599412 ISSN=2624-8212 ABSTRACT=IntroductionResearchers in biomedicine and public health often spend weeks locating, cleansing, and integrating data from disparate sources before analysis can begin. This redundancy slows discovery and leads to inconsistent pipelines.MethodsWe created BioBricks.ai, an open, centralized repository that packages public biological and chemical datasets as modular “bricks.” Each brick is a Data Version Control (DVC) Git repository containing an extract‑transform‑load (ETL) pipeline. A package‑manager–like interface handles installation, dependency resolution, and updates, while data are delivered through a unified backend (https://biobricks.ai).ResultsThe current release provides >90 curated datasets spanning genomics, proteomics, cheminformatics, and epidemiology. Bricks can be combined programmatically to build composite resources; benchmark use‑cases show that assembling multi‑dataset analytic cohorts is reduced from days to minutes compared with bespoke scripts.DiscussionBioBricks.ai accelerates data access, promotes reproducible workflows, and lowers the barrier for integrating heterogeneous public datasets. By treating data as version‑controlled software, the platform encourages community contributions and reduces redundant engineering effort. Continued expansion of brick coverage and automated provenance tracking will further enhance FAIR (Findable, Accessible, Interoperable, Reusable) data practices across the life‑science community.