Simultaneous solar wind measurements from the solar wind monitors, WIND and ACE, differ due to the spatial and temporal structure of the solar wind. Correlation studies that use these measurements as input may infer an incorrect correlation due to uncertainties arising from this spatial and temporal structure, especially at extreme and rare solar wind values. In particular, regression analysis will lead to a regression function whose slope is biased towards the mean value of the measurement parameter. This article demonstrates this regression bias by comparing simultaneous ACE and WIND solar wind measurements. A non-linear regression analysis between them leads to a perception of underestimation of extreme values of one measurement on average over the other. Using numerical experiments, we show that popular regression analysis techniques such as linear least-squares, orthogonal least-squares, and non-linear regression are not immune to this bias. Hence while using solar wind parameters as an independent variable in a correlation or regression analysis, random uncertainty in the independent variable can create unintended biases in the response of the dependent variable. More generally, the regression to the mean effect can impact both event-based, statistical studies of magnetospheric response to solar wind forcing.