AUTHOR=Iman Ismail Nurul , Yusof Nurul Aiman Mohd , Talib Ummi Nasrah , Ahmad Nur Aimi Zawami , Norazit Anwar , Kumar Jaya , Mehat Muhammad Zulfadli , Jayabalan Nanthini , Muthuraju Sangu , Stefaniuk Marzena , Kaczmarek Leszek , Muzaimi Mustapha 

TITLE=The IntelliCage System: A Review of Its Utility as a Novel Behavioral Platform for a Rodent Model of Substance Use Disorder

JOURNAL=Frontiers in Behavioral Neuroscience

VOLUME=Volume 15 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/behavioral-neuroscience/articles/10.3389/fnbeh.2021.683780

DOI=10.3389/fnbeh.2021.683780

ISSN=1662-5153

ABSTRACT=The use of animal models for substance use disorder (SUD) has made an important contribution in the investigation of behavioral and molecular mechanisms underlying substance abuse and addiction. Here we review a novel and comprehensive behavioral platform to characterize addiction-like traits in rodent using a fully automated learning system, the IntelliCage. This system simultaneously captures basic behavioral navigation, reward preference and aversion, as well as multi-dimensional complex behaviors and cognitive functions of group-housed rodent. It can reliably capture, and track locomotor and cognitive pattern alterations associated with the development of substance addiction. Thus, the IntelliCage learning system offers a potentially efficient, flexible, and sensitive tool for high-throughput screening of rodent SUD model.