AUTHOR=Yang Xing , Luo Yuan , Li Sanpeng , Xu Xiuli , Bao Yingxia , Yang Jiaming , Ouyang Defang , Fan Xingxing , Gong Ping , Cai Lintao 

TITLE=Small Molecular Prodrug Amphiphile Self-Assembled AIE Dots for Cancer Theranostics

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 8 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2020.00903

DOI=10.3389/fbioe.2020.00903

ISSN=2296-4185

ABSTRACT=A facile and simple one-step method was developed to fabricate small molecular prodrug amphiphile self-assembled organic dots CPPG with aggregation-induced emission (AIE) characteristics. With integration the advantages of AIE aggregates with strong emission and the cell-targeting capability of small molecular prodrug amphiphile CPPG, the as-prepared CPPG AIE dots can specifically target to cancer cells and inhibit the proliferation of the cancer cells with good biocompatibility photostability. Based on this universal method, a variety of versatile organic fluorescent nanoprobes with high brightness, specific recognition and clinical-transitional potential could be facilely constructed for biological therapeutics and imaging applications.