AUTHOR=Cidem Aylin , Bradbury Peta , Traini Daniela , Ong Hui Xin TITLE=Modifying and Integrating in vitro and ex vivo Respiratory Models for Inhalation Drug Screening JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=Volume 8 - 2020 YEAR=2020 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2020.581995 DOI=10.3389/fbioe.2020.581995 ISSN=2296-4185 ABSTRACT=
For the past 50 years, the route of inhalation has been utilized to administer therapies to treat a variety of respiratory and pulmonary diseases. When compared with other drug administration routes, inhalation offers a targeted, non-invasive approach to deliver rapid onset of drug action to the lung, minimizing systemic drug exposure and subsequent side effects. However, despite advances in inhaled therapies, there is still a need to improve the preclinical screening and the efficacy of inhaled therapeutics. Innovative