AUTHOR=Zhang Cheng , Zhang Tianjia , Geng Tengyu , Wang Xudong , Lin Kaili , Wang Penglai 

TITLE=Dental Implants Loaded With Bioactive Agents Promote Osseointegration in Osteoporosis: A Review

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2021.591796

DOI=10.3389/fbioe.2021.591796

ISSN=2296-4185

ABSTRACT=Implant denture is widely used in patients with dentition defect or loss, which has higher chewing efficiency and will not damage the adjacent teeth, compared to the fixed or removable denture. Till now, implant denture is still at risk of failure in some systemic diseases, including osteoporosis, due to non-ideal local microenvironment. Ordinary physical and chemical modifications are used to change the roughness of implant surface to promote osseointegration, however, their effect is limited in osteoporotic patients. Recently, many researchers focus on the study of bioactive modification of implant and have amount promising results. Herein, we summarize the progress in bioactive modification strategy for promoting osseointegration via regulating the local osteoporotic microenvironment.