AUTHOR=Ha Eun Ju , Yun Jang-Hyuk , Si Chuanling , Bae Young Soo , Jeong Young-Hwan , Park Kwang-Hyun , Choi Sun-Eun 

TITLE=Application of Ethanol Extracts From Alnus sibirica Fisch. ex Turcz in Hair Growth Promotion

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2021.673314

DOI=10.3389/fbioe.2021.673314

ISSN=2296-4185

ABSTRACT=Alnus sibirica Fisch. ex Turcz (ASFT), a kind of biomass belonging to the family of Betulaceae, grows naturally in Asia, Europe and America. Generally, there are various constituents in ASFT than can be applied in different bio-fields. In this work, the extract of diarylheptanoid in ASFT branch was isolated and purified using 60% ethanol to determine its preventing effects of hair loss. We investigated anti-oxidative, anti-apoptotic effects on hydrogen peroxide-induced cytotoxicity on human hair dermal papilla cells using MTT assay and Western blotting, respectively. Moreover, we examined ameliorative effects of the extracts of ASFT and oregonin against changes of oxidative stress-induced cytokine and testosterone-induced dihydrotestosterone (DHT) production as crucial pathway on hair loss mechanism. These results suggest that the 60% alcohol extract of ASFT were available candidate for novel natural biomass on maintaining hair health of mammals.