AUTHOR=Bao Jianfeng , Guo Shuangshuang , Zu Xiangyang , Zhuang Yuchuan , Fan Dandan , Zhang Yong , Shi Yupeng , Ji Zhenyu , Cheng Jingliang , Pang Xin 

TITLE=Polypyrrole-Coated Magnetite Vortex Nanoring for Hyperthermia-Boosted Photothermal/Magnetothermal Tumor Ablation Under Photoacoustic/Magnetic Resonance Guidance

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2021.721617

DOI=10.3389/fbioe.2021.721617

ISSN=2296-4185

ABSTRACT=Photothermal/Magnetothermal based hyperthermia cancer therapy techniques are central research themes and the associated nanotechnology-assisted treatments have shown promising clinical potentials. However, either method has its own limitation, which has impeded the extensive applications. For example, the photothermal is limited by the penetration ability, while the heating efficiency of magnetothermal is very poor. In this paper, a novel magnetite vortex nanoring nanoparticle coated with polypyrrole (demoted as nanoring Fe3O4@PPy-PEG) was first synthesized and well-characterized, and the outstanding dual-enhanced hyperthermia performances by combined photothermal and magnetothermal effects were thoroughly examined. Benefiting from the magnetite vortex nanoring and polypyrrole, Fe3O4@PPy-PEG showed excellent hyperthermia effects (SAR = 1648 W g-1) when simultaneously exposed to the alternating magnetic field (300 kHz, 45 A) and near-infrared (808 nm, 1 W cm-2) laser. What’s more, nanoring Fe3O4@PPy-PEG showed a much faster heating rate, which can further augment the antitumor effect by incurring vascular disorder, compared to either method. Besides, Fe3O4@PPy-PEG exhibited a high transverse relaxation rate (60.61 mM-1 S-1[Fe]) at a very low B0 field (0.35 T) and good photoacoustic effect. We believe that the results obtained herein can significantly promote the development of multifunctional nanoparticles-mediated magnetic and photo induced efficient hyperthermia therapy.