AUTHOR=Huang Chuangjia , Guan Xiaoling , Lin Hui , Liang Lu , Miao Yingling , Wu Yueheng , Bao Huiqiong , Wu Xiaodan , Shen Ao , Wei Minyan , Huang Jionghua 

TITLE=Efficient Photoacoustic Imaging With Biomimetic Mesoporous Silica-Based Nanoparticles

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2021.762956

DOI=10.3389/fbioe.2021.762956

ISSN=2296-4185

ABSTRACT=Indocyanine green (ICG), a near-infrared (NIR) fluorescent dye approved by Food and Drug Administration (FDA), has been extensively used as a photoacoustic (PA) probe for PA imaging. However, its practical application is limited by the poor photostability in water, rapid body clearance and nonspecificity. Herein, we fabricated a novel biomimetic nanoprobe by coating ICG loaded mesoporous silica nanoparticles with the cancer cell membrane (namely, CMI) for PA imaging. This probe exhibited well dispersion, large loading efficiency, good biocompatibility and homologous targeting ability to Hela cells in vitro. Furthermore, the in vivo and ex vivo PA imaging on Hela tumor-bearing nude mice demonstrated that CMI could accumulate in tumor tissue and display a superior PA imaging efficacy compared with free ICG. All these results demonstrated that CMI might be a promising contrast agent for photoacoustic imaging of cervical carcinoma.