AUTHOR=Tang Xiangjun , Zhu Jing , Zhu Fangcheng , Tu Hanjun , Deng Aiping , Lu Junti , Yang Minghuan , Dai Longjun , Huang Kuanming , Zhang Li 

TITLE=Case Report: Primary Pulmonary Angiosarcoma With Brain Metastasis

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 9 - 2021

YEAR=2022

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2021.803868

DOI=10.3389/fbioe.2021.803868

ISSN=2296-4185

ABSTRACT=Primary pulmonary angiosarcoma (PPA) is an extremely rare malignant vascular tumor. It has no specific clinical manifestation and is challenging to diagnose early. Here, we report a case of PPA with brain metastasis. A 21-year-old patient hospitalized for a head injury. Cranial MRI showed multiple intracranial lesions with brain edema. Pulmonary CT displayed bilateral pulmonary infection with mediastinal lymph node enlargement. After anti-tuberculosis treatment, the patient's symptoms progressively aggravated, accompanied by epileptic seizures, coughing and phlegm mixed with blood. The treatment was ineffective and the patient’s condition deteriorated sharply, leading to a coma. It took less than three months from symptom onset to death. PPA with brain metastasis was confirmed by autopsy.