AUTHOR=Fan Tiantang , Qin Jingwen , Meng Xiao , Li Jiafeng , Liu Qing , Wang Guannan 

TITLE=Biodegradable membrane of poly(l-lactide acid-dioxanone-glycolide) and stereocomplex poly(lactide) with enhanced crystallization and biocompatibility

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.1021218

DOI=10.3389/fbioe.2022.1021218

ISSN=2296-4185

ABSTRACT=The mebranes of poly(L-lactide acid-p-dioxanone-glycolide) (PLPG) with stereocomplex poly(lactic acid) (sc-PLA) were prepared by the solution blending way. It was observed that sc-PLA significantly heightened the crystallizing behavior of PLLA segments of PLPG metrix. And, the crystallizing behavior displayed that the temperature of crystallization shifted to a higher range than that of the PLPG. Moreover, half-time of crystallization sharply decreased in value as sc-PLA content increased in value on account of the pre-eminent nucleation ability of sc-PLA. TGA results revealed the thermal stability of the samples with the increase of sc-PLA compared to PLPG. Meanwhile, enzymatic degradation results indicated the mass loss rate of the mebrane decreased as the introduction of sc-PLA, but the overall degradation ability was still greater than that of PLLA. In the meantime, the biological experiment indicated that the mebrane possessed low cytotoxicity.