Due to a production error, a spelling error was introduced in an accession ID in the text. A correction has been made to the section The Missing Piece: Coordinating a Single Function Using a Hierarchy of Local Regulators, the Concilion, paragraph 2. The corrected paragraph appears below.
“We defined this novel structure, previously only loosely named module, as the concilion [kon’si.li.on]. The term is derived from the Latin noun concilium, council or meeting, and the verb conciliō, to unite, to bring together. This refers to the group of structural genes and their local regulators responsible for a single function that, organized hierarchically, coordinates a response in a way reminiscent of the deliberation and negotiation that take place in a council (Figure 1A, bottom left). Concilions may be differentiated from regulons because the former exhibits interactions between their regulators resembling a hierarchical circuit that could even include some feedback and cross-regulation. Moreover, concilions do not contain any global regulator, they are local regulation devices devoted to a unique, well-defined function, contrary to modulons that include a global regulator by definition and control a diversity of functions. By analyzing a non-redundant set containing the most recent GRN for each of the 42 bacteria in Abasy Atlas, we found that, on average, roughly 17% of the modules identified by the natural decomposition approach (NDA, see next section) in a GRN are concilions. Furthermore, in the most recent reconstruction of the E. coli GRN (Abasy Atlas regnetid: 511145_v2020_sRDB18-13), we found that about 25% of the modules are concilions whereas the remainder modules are simple or complex regulons, highlighting the important role of the concilion in the functional architecture.”
The publisher apologizes for this mistake. The original version of this article has been updated.
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Summary
Keywords
gene regulatory networks, organization, functional architecture, system principles, hierarchy, consistency, incompleteness, evolution
Citation
Frontiers Production Office (2022) Erratum: System principles governing the organization, architecture, dynamics, and evolution of gene regulatory networks. Front. Bioeng. Biotechnol. 10:1091728. doi: 10.3389/fbioe.2022.1091728
Received
07 November 2022
Accepted
07 November 2022
Published
02 December 2022
Approved by
Frontiers Editorial Office, Frontiers Media SA, Switzerland
Volume
10 - 2022
Updates
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This article was submitted to Synthetic Biology, a section of the journal Frontiers in Bioengineering and Biotechnology
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.