AUTHOR=Lu Huiting , Zada Shah , Yang Lingzhi , Dong Haifeng 

TITLE=Microneedle-Based Device for Biological Analysis

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.851134

DOI=10.3389/fbioe.2022.851134

ISSN=2296-4185

ABSTRACT=The collection and analysis of biological samples is an effective means of disease diagnosis and treatment. Blood sampling is a traditional approach in biological analysis. However, this approach is inextricably associated with invasive techniques, and blood sampling is usually performed by a professional. The microneedles (MNs)-based devices has gained increasing attention due to its non-invasive manner compared traditional blood-based analysis method. In present review we introduce the materials for fabrication of MNs. We categorize MNs-based device based on four classes: MNs for transdermal sampling, biomarker capture, detection or monitoring analytes, and bio-signal recording. The design strategies and corresponding application of them are highlight and discussed in detail. Finally, future perspectives of MNs-based device are discussed.