AUTHOR=Gao Xiang , Wang Wanchun , Gao Meihua 

TITLE=Preparation of Novel ICT-CMC-CD59sp Drug-Loaded Microspheres and Targeting Anti-Tumor Effect on Oral Squamous Cell Carcinoma

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.878456

DOI=10.3389/fbioe.2022.878456

ISSN=2296-4185

ABSTRACT=The treatment of oral squamous cell carcinoma (OSCC) remains a great clinical challenge, and the malignant proliferation of OSCC cells can lead to the overexpression of CD59. In this study, a novel microsphere (ICT-CMC-CD59sp) composed of icariin (ICT), carboxymethyl chitosan (CMC) and cell differentiation antigen 59-specific ligand peptide (CD59sp) were successfully prepared by emulsion cross-linking method. Through the guidance of CD59sp, microspheres can target OSCC cells and play a therapeutic role (P<0.01). MTT test and trypan blue staining showed that the above microspheres could promote the apoptosis of oral squamous cell carcinoma and had significant difference (P<0.01). In this study, the regulatory effect of the microspheres on OSCC cells was investigated at the cellular level, and its therapeutic effect on OSCC was discussed, which provided a new idea for the targeted therapy of OSCC.