AUTHOR=Luo Xingyu , Cao Jian , Yu Jianming , Dai Dongqing , Jiang Wei , Feng Yahui , Hu Yong 

TITLE=Regulating Acidosis and Relieving Hypoxia by Platelet Membrane-Coated Nanoparticle for Enhancing Tumor Chemotherapy

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.885105

DOI=10.3389/fbioe.2022.885105

ISSN=2296-4185

ABSTRACT=Acidosis and hypoxia of tumor remains the great challenge for cancer therapy. Herein, we developed Hb-LOX-DOX-ZIF8@Platelet Membrane nanoparticles (H-L-D-Z@PM NPs) to address this problem. The lactate oxidase (LOX) could deplete intratumoral lactate adequately and amplify oxidative stress efficiently. In the meantime, hemoglobin (Hb) was intended for delivering oxygen to relieve hypoxia and boosting the catalytic activity of LOX. The coated PM bestowed active tumor-targeting ability and good biocompatibility to the nanoparticles. Moreover, the encapsulation of zeolitic imidazolate framework-8(ZIF8) offered the acid response capacity to nanoparticles. With the synergism of chemotherapy drug doxorubicin (DOX), these H-L-D-Z@PM NPs appeared excellent anti-tumor competence. Collectively, this study offered a new strategy for enhancing tumor chemotherapy by regulating acidosis and relieving hypoxia.